Appraising Religious Liberty in the Philippine Reproductive Health Debates

The debates surrounding the reproductive health bills created controversy and division between the Philippine government and the Church leaders. The government proposed laws that would promote accessible health care to women and children, including access to safe and effective contraceptives. The Catholic bishops opposed these bills, which they considered as inconsistent with Church teachings on sexuality and marriage. Following a modified pastoral circle, this thesis describes the Philippine situation and genealogy of the debates, analyzes the critical position of the bishops, and proposes how the right to religious freedom can provide a paradigm of examining the debates. The bishops\u27 opposition conflated the distinct moral issues of abortion and contraception and framed them on a physicalist interpretation of the natural law. By appraising religious liberty, this thesis shows that the language of human dignity and rights provides a persuasive argument against abortion. Grounding their position against contraception on the Catholic teleology of marriage, conversely, doesn\u27t give a compelling argument to warrant the legislation of laws in a pluralistic society. The thesis concludes that religious freedom provides a framework that is relevant in addressing the persistent questions on reproductive health as well as emerging issues on matters of women\u27s rights and social justice

Teachers' Attributes and Self-Efficacy as Predictors of Classroom Management

This descriptive-correlational research examined the teachers' attributes and self-efficacy as predictors to classroom management. The study aims to help teachers, school principals, and future researchers address some classroom management gaps. This study was participated by 200 senior high school teachers of Monkayo, Davao de Oro. The instruments used in gathering the data were adopted, content validated, and reliability tested. The result showed that the extent of teachers' attributes was very great, and the level of teachers' self-efficacy was also very high. As a result, the level of classroom management of teachers was described as very high. The result further showed the significant relationship between teachers' attributes to classroom management. Lastly, this study revealed that teachers' attributes and self-efficacy significantly predict classroom management. Therefore, the study recommends that the elementary school administrators develop programs that equip teachers with the necessary attributes, skills, and passion for the teaching profession and be given more professional growth consideratio

Privileged high school girls' responses to depictions of femininity in popular young adult literature

Thesis (Ed.D.)--Boston UniversityYoung adult literature has been a subject of contention for educators, adolescent psychologists, and critics for decades. Although some commentators maintain that young adult literature can be educationally and developmentally beneficial for adolescent readers, others argue that it often contains negative and potentially harmful messages that could influence its readers during a time when they are most vulnerable. Despite the claims on both sides, little substantive research exists on how older adolescent girls, the intended audience for these books, respond to the texts. This qualitative study examined three popular works of young adult literature to identify the overlapping messages they have regarding the depiction of adolescent females. Five adolescent girls, ages 14-17, read the books and met with the researcher in a series of one-on-one interviews to discuss their responses to the books, specifically the depiction of female characters. The participants also completed journal entries on the books and surveys on their reading habits and responses to the specific characters from the books in the study. The findings indicate these participants interpreted the books in distinctive ways based on their experiences and in keeping with prior research on adolescent development and reader response. The participants also took a critical approach to the books to find parallels to their own lives

Diseño del crucero 077, para interceptar la veta troncal e incrementar las reservas, minera Yanaquihua unidad Alpacay

La continuidad de Minera Yanaquihua S.A.C. depende de la profundización de la misma, lo que hace imprescindible hacer el desarrollo de la mina mediante el diseño y construcción de un Crucero de 160 m de longitud, que con dicha dimensión alcanzará a interceptar la veta Troncal pero pondrá más cerca a poder interceptar otras vetas como Troncal, B1, B2, Despresiada y Katty De esta manera, nace el presente proyecto de investigación, teniendo como objetivo principal extraer los recursos minerales entre los niveles 2000 y 2050, hacer un plan de minado en función a las leyes, tonelajes y precios de mineral. Para ser posible el acceso a los recursos minerales existentes entre los niveles 2000 y 2050 de Minera Yanaquihua S.A.C, se plantea profundizar la mina mediante el desarrollo del Crucero 077 que servirán de acceso a estos recursos y como medio de transporte para la extracción del mineral y desmonte, aprovechando la infraestructura existente en la mina. Al igual que también se hizo un diseño y la construcción del crucero 077 para la interceptar la veta Troncal, siguiendo los lineamientos descritos en el Reglamento de Seguridad y Salud Ocupacional, tipificado en el Decreto Supremo Nº 024-2016 E.M. con su modificatoria Decreto Supremo Nº 023-2017 E.M. Con la ejecución del crucero 077 y labores de desarrollo se garantizará la explotación de la mina de forma continua y así lograr la optimización de los procesos de minado; de esta manera se mejorarán los niveles de producción y productividad. En el capítulo de análisis y resultados se va determinar el costo por de ejecución del crucero 077, el cual asciende a 230.68 US$/, en base indicadores económicos como es el VAN y el TIR, se determina la viabilidad del crucero 077, con resultados positivos con un VAN de 335 594 US$, y un TIR de 23

MEF/ELF4 transactivation by E2F1 is inhibited by p53

Myeloid elf-1-like factor (MEF) or Elf4 is an E-twenty-six (ETS)-related transcription factor with strong transcriptional activity that influences cellular senescence by affecting tumor suppressor p53. MEF downregulates p53 expression and inhibits p53-mediated cellular senescence by transcriptionally activating MDM2. However, whether p53 reciprocally opposes MEF remains unex-plored. Here, we show that MEF is modulated by p53 in human cells and mice tissues. MEF expression and promoter activity were suppressed by p53. While we found that MEF promoter does not contain p53 response elements, intriguingly, it contains E2F consensus sites. Subsequently, we determined that E2F1 specifically binds to MEF promoter and transactivates MEF. Nevertheless, E2F1 DNA binding and transactivation of MEF promoter was inhibited by p53 through the association between p53 and E2F1. Furthermore, we showed that activation of p53 in doxorubicin-induced senescent cells increased E2F1 and p53 interaction, diminished E2F1 recruitment to MEF promoter and reduced MEF expression. These observations suggest that p53 downregulates MEF by associating with and inhibiting the binding activity of E2F1, a novel transcriptional activator of MEF. Together with previous findings, our present results indicate that a negative regulatory mechanism exists between p53 and MEF

CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome

AIMS Evacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor under development for reducing cardiovascular events in patients with high risk vascular disease. CETP inhibitors are likely to be utilized as ‘add-on’ therapy to statins in patients receiving concomitant medications, so the potential for evacetrapib to cause clinically important drug–drug interactions (DDIs) with cytochromes P450 (CYP) was evaluated. METHODS The DDI potential of evacetrapib was investigated in vitro, followed by predictions to determine clinical relevance. Potential DDIs with possible clinical implications were then investigated in the clinic. RESULTS In vitro, evacetrapib inhibited all of the major CYPs, with inhibition constants (Ki) ranging from 0.57 μM (CYP2C9) to 7.6 μM (CYP2C19). Evacetrapib was a time-dependent inhibitor and inducer of CYP3A. The effects of evacetrapib on CYP3A and CYP2C9 were assessed in a phase 1 study using midazolam and tolbutamide as probe substrates, respectively. After 14 days of daily dosing with evacetrapib (100 or 300 mg), midazolam exposures (AUC) changed by factors (95% CI) of 1.19 (1.06, 1.33) and 1.44 (1.28, 1.62), respectively. Tolbutamide exposures (AUC) changed by factors of 0.85 (0.77, 0.94) and 1.06 (0.95, 1.18), respectively. In a phase 2 study, evacetrapib 100 mg had minimal impact on AUC of co-administered simvastatin vs. simvastatin alone with a ratio of 1.25 (1.03, 1.53) at steady-state, with no differences in reported hepatic or muscular adverse events. CONCLUSIONS Taken together, the extent of CYP-mediated DDI with the potential clinical dose of evacetrapib is weak and clinically important DDIs are not expected to occur in patients taking concomitant medications.Ellen A. Cannady, Jeffrey G. Suico, Ming-Dauh Wang, Stuart Friedrich, Jessica R. F. Rehmel, Stephen J. Nicholls, Kathryn A. Kruege

Cumplimiento del protocolo COVID-19 y el bienestar laboral de los trabajadores administrativos de la municipalidad distrital de Cayma del 2021

La presente investigación tiene por finalidad determinar la relación entre el cumplimiento del protocolo Covid-19 y el bienestar laboral de los trabajadores administrativos de la Municipalidad Distrital de Cayma del 2021. El enfoque de la tesis es cuantitativo, de tipo básico, con un diseño descriptivo correlacional, de corte transversal. La muestra fue censal, estuvo conformado por 100 trabajadores administrativos de la Municipalidad Distrital de Cayma, a ellos se les aplicó un cuestionario con 59 items, mediante la técnica de la encuesta. Se concluye que existe correlación positiva y significativa la variable cumplimiento del protocolo Covid-19 y el bienestar laboral, existiendo entre ellas una correlación positiva y SIGNIFICATIVA, lo cual se demuestra con el valor obtenido con el estadístico Rho de Spearman (R= 0,590), así mismo en cuanto al valor de significancia obtenido, al ser menor al valor 0,005 nos permite valida la hipótesis de investigación planteada, la cual dice: “Existe relación directa y significativa entre el cumplimiento del protocolo Covid-19 y el bienestar laboral de los trabajadores administrativos de la Municipalidad Distrital de Cayma del 2021”

Parents’ Level of Engagement in the Modular Distance Learning of Elementary School Students

The primary purpose of the study was to determine the level of parents’ engagement in the modular learning of elementary school students. The researchers used survey questionnaires as an instrument, utilized the descriptive type of research and total population sampling in the selection of the respondents, the entire parents of Grades 4-6 was studied. The respondents of this study are the 30 parents which are categorized based on their educational attainment and family monthly income. The researchers used the adapted research questionnaire from the study of Gumapac, et al., (2022) which based on the three indicators: sustaining motivation, coaching and tutoring and monitoring student’s compliance. The result of the study showed that there is no significance difference in the parents’ level of engagement in modular learning when categorized according to educational attainment and family monthly income. Parents are encouraged to continue to support and motivate their children in various aspects and encourage their children to continue in schooling despite on the family income or educational attainment of their parents. Furthermore, the future researchers should conduct the same study in different schools, particularly in Island Garden City of Samal

Trimerization and genotype-phenotype correlation of COL4A5 mutants in Alport syndrome

INTRODUCTION: Alport syndrome is a hereditary glomerulonephritis that results from the disruption of collagen α345(IV) heterotrimerization caused by mutation in METHODS: We selected 9 α5(IV) missense mutants with typical glycine substitutions that clinically differed in disease progression. To quantify the trimerization of each mutant, split nanoluciferase-fused α3/α5 mutants and α4 were transfected into the cells, and intracellular and secreted heterotrimer were detected by luminescence using an assay that we developed previously. RESULTS: Trimer formation and secretion patterns tended to be similar to the wild type in most of the mutations that did not show proteinuria at a young age. On the other hand, trimer secretion was significantly reduced in all the mutations that showed proteinuria and early onset of renal failure. One of these mutants has low ability of intracellular trimer formation, and the others had the defect of low-level secretion. In addition, the mutant that is assumed to be nonpathogenic has similar trimer formation and secretion pattern as wild-type α5(IV). CONCLUSION: The result of cell-based α345(IV) heterotrimer formation assay was largely correlated with clinical genotype-phenotype. These trimerization assessments provide additional phenotypic considerations and may help to distinguish between pathogenic and nonpathogenic mutations

Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator

AbstractCystic fibrosis (CF) is the most common lethal genetic disease in Caucasians caused by the trafficking defects of CF transmembrane conductance regulator (CFTR), which is a cAMP-dependent Cl− channel at the plasma membrane. The trafficking pathway of CFTR is thought to be non-conventional because CFTR maturation is inhibited by the dysfunction of syntaxin 13, which is involved in protein recycling via endosomal pathway. In this study, to clarify whether the endosomal trafficking is required for CFTR maturation, we utilized a specific vacuolar H+-ATPase inhibitor, bafilomycin A1 (BafA1), which inhibits the protein trafficking from early endosome. Our data showed that low concentration of BafA1 (50nM) decreased the expression of mature CFTR but induced the accumulation of immature CFTR in the juxta-nuclear region containing an early endosome marker. Pulse-chase analysis showed that BafA1 inhibited the maturation of CFTR, but it slightly stabilized immature CFTR. These results indicate that BafA1-sensitive pathway is required for CFTR maturation and emphasize that endosomal trafficking pathway might be involved in the maturation of CFTR