The Influence of Mixed Reality on Satisfaction and Brand Loyalty in Cultural Heritage Attractions: A Brand Equity Perspective

Mixed reality technology is being increasingly used in cultural heritage attractions to enhance visitors’ experience. However, how the characteristics of mixed reality affect satisfaction and brand loyalty has not been explored in previous research. The purpose of this study is to identify factors affecting satisfaction with mixed reality experiences at cultural and artistic visitor attractions and their influence on brand loyalty, which is connected with management performance. We propose a theoretical model based on brand equity theory in the context of mixed reality experience. Survey data were gathered from 251 respondents visiting a cultural and artistic visitor attraction in Seoul, Korea using a stratified sampling method. PLS-SEM was employed for the data analysis. The results suggest that the characteristics of mixed reality (interactivity, vividness) not only influence the affective aspects (perceived immersion, perceived enjoyment) of visitors’ experience, but also positively affect brand awareness, brand association, and brand loyalty

Effect of Virtual Reality based nursing skills on the performance ability, performance confidence, and practice satisfaction of nursing college students

The development and application of remote learning using immersive technology have been accelerated in nursing colleges due to recent technological advances and the Covid-19 pandemic. Although virtual nursing education is effective in improving nursing competency by improving metacognition, there is limited research to examine the effectiveness of virtual nursing education. Therefore, this study aims to examine the effects of using virtual reality to learn core nursing techniques measured via ratings of performance ability, confidence, and practice satisfaction. Thirty nursing students were split into three experimental groups based on practice content utilized: 1) HMD-based VR, 2) Web-based VR, and 3) video practice. Each group was required to perform intradermal and intravenous injection techniques. Confidence and satisfaction of the group using VR content were rated higher than the group with general video learning. This study supports that virtual reality-based nursing education is a useful tool for practical education through metacognition and could serve as a new alternative to nursing education in a pandemic environment

The Impact of Advance Directive Perspectives on the Completion of Life-Sustaining Treatment Decisions in Patients with Heart Failure: A Prospective Study

Evidence for non-modifiable and modifiable factors associated with the utilization of advance directives (ADs) in heart failure (HF) is lacking. The purpose of this study was to examine baseline-to-3-month changes in knowledge, attitudes, and benefits/barriers regarding ADs and their impact on the completion of life-sustaining treatment (LST) decisions at 3-month follow-up among patients with HF. Prospective, descriptive data on AD knowledge, attitudes, and benefits/barriers and LSTs were obtained at baseline and 3-month follow-up after outpatient visits. Of 64 patients (age, 68.6 years; male, 60.9%; New York Heart Association (NYHA) classes I/II, 70.3%), 53.1% at baseline and 43.8% at 3-month follow-up completed LST decisions. Advanced age (odds ratio (OR) = 0.91, p = 0.012) was associated with less likelihood of the completion of LST decisions at 3-month follow-up, while higher education (OR = 1.19, p = 0.025) and NYHA class III/IV (OR = 4.81, p = 0.049) were associated with more likelihood. In conclusion, advanced age predicted less likelihood of LST decisions at 3 months, while higher education and more functional impairment predicted more likelihood. These results imply that early AD discussion seems feasible in mild symptomatic HF patients with poor knowledge about ADs, considering the non-modifiable and modifiable factors

Diamine-Anchored Polystyrene Resins for Reversible SO₂ Adsorption

Diamine-anchored Merrifield resins ([DAMR]­CH₃SO₃; DA = diamine, MR = Merrifield resin, X = Cl, CH₃SO₃, and (CF₃SO₂)₂N), synthesized from the reactions of Merrifield resin with a tertiary diamine selected from <i>N</i>,<i>N</i>,<i>N</i>′<i>N</i>′-tetramethylethylenediamine (TMEDA), 1,4-dimethylpiperazine (DMP), and 1,4-diazabicyclo­[2,2,2]­octane (DABCO), were found to exhibit excellent performance as SO₂ adsorbents under both hydrous and dry conditions. Under dry conditions, the molar SO₂ adsorption capacity of [DAMR]­X was greatly affected by the nucleophilicity of the anion but was rarely influenced by the type of diamine anchored on the cation. In contrast, under hydrous conditions, the SO₂ adsorption and desorption behaviors on [DAMR]­X were strongly affected by the basicity of the diamine on the cation, [DAMR]⁺. Spectroscopic and experimental results suggest that in the presence of water SO₂ is adsorbed on [DAMR]­X as a bisulfite species, and the formation and the stability of the bisulfite species increase with the increasing basicity of the diamine of [DAMR]⁺. SO₂ adsorbed on [DABCOMR]­X was found to completely desorb at 80 °C, irrespective of the presence of water

Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Prolyl-tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We developed a novel compound, DWN12088, whose safety was validated by clinical phase 1 studies, and therapeutic efficacy was shown in idiopathic pulmonary fibrosis model. Structural and kinetic analyses revealed that DWN12088 binds to catalytic site of each protomer of PARS1 dimer in an asymmetric mode with different affinity, resulting in decreased responsiveness at higher doses, thereby expanding safety window. The mutations disrupting PARS1 homodimerization restored the sensitivity to DWN12088, validating negative communication between PARS1 promoters for the DWN12088 binding. Thus, this work suggests that DWN12088, an asymmetric catalytic inhibitor of PARS1 as a novel therapeutic agent against fibrosis with enhanced safety