Fabrication of Carbon Nanofiber Incorporated with CuWO₄ for Sensitive Electrochemical Detection of 4-Nitrotoluene in Water Samples

In the current work, copper tungsten oxide (CuWO4) nanoparticles are incorporated with carbon nanofiber (CNF) to form CNF/CuWO4 nanocomposite through a facile hydrothermal method. The prepared CNF/CuWO4 composite was applied to the electrochemical detection of hazardous organic pollutants of 4-nitrotoluene (4-NT). The well-defined CNF/CuWO4 nanocomposite is used as a modifier of glassy carbon electrode (GCE) to form CuWO4/CNF/GCE electrode for the detection of 4-NT. The physicochemical properties of CNF, CuWO4, and CNF/CuWO4 nanocomposite were examined by various characterization techniques, such as X-ray diffraction studies, field emission scanning electron microscopy, EDX-energy dispersive X-ray microanalysis, and high-resolution transmission electron microscopy. The electrochemical detection of 4-NT was evaluated using cyclic voltammetry (CV) the differential pulse voltammetry detection technique (DPV). The aforementioned CNF, CuWO4, and CNF/CuWO4 materials have better crystallinity with porous nature. The prepared CNF/CuWO4 nanocomposite has better electrocatalytic ability compared to other materials such as CNF, and CuWO4. The CuWO4/CNF/GCE electrode exhibited remarkable sensitivity of 7.258 μA μM−1 cm−2, a low limit of detection of 86.16 nM, and a long linear range of 0.2–100 μM. The CuWO4/CNF/GCE electrode exhibited distinguished selectivity, acceptable stability of about 90%, and well reproducibility. Meanwhile, the GCE/CNF/CuWO4 electrode has been applied to real sample analysis with better recovery results of 91.51 to 97.10%

Biosynthesis of silver nanoparticles derived Acorus Calamus rhizome extract and their biomedical application

The silver nanoparticles (Ag NPs) were derived from Acorus calamus (A. calamus) rhizome extract using different temperature. The absorbance centered at 439 nm, which was corresponds to the wavelength of the surface plasmon resonance of Ag NPs at 95 ◦C. From FESEM and TEM image showed, the Ag NPs were exhibited spherical structure. Elemental compositions were identified by EDAX analysis. The synthesized Ag NPs, functional groups were identified by the FTIR spectra. The antibacterial studies performed against a set of bacterial strains showed that the Ag NPs possessed a greater antibacterial effect than the Plant extract (PE) and silver nitrate. In-vitro cytotoxic effect of green synthesized A. calamus rhizome extract derived Ag NPs tested against MG 63, MCF-7 and HeLa cell lines

Str\"{o}mgren photometric metallicity of the Small Magellanic Cloud stars using Gaia DR3-XP spectra

Observational studies have identified several sub-structures in different regions of the Magellanic Clouds, the nearest pair of interacting dwarf satellites of the Milky Way. By studying the metallicity of the sources in these sub-structures, we aim to shed light on the possible origin of these sub-structures. Spectroscopic metallicities exist only for a few thousand sources, mostly giant stars located in specific regions of the galaxies. These metallicities come from different instruments at various spectral resolutions, and systematic uncertainties hamper comparisons and draw firm conclusions about their origin. The third data release of \textit{Gaia} has provided us with $\sim$ 0.17 million XP spectra of the different stellar populations in the SMC alone as faint as $\sim$ 18 mags in the G band, which are spread across $\sim$ 10$^\circ$ from the SMC centre. We aim to determine the metallicities of these sources based on synthetic Str\"{o}mgren photometry derived from XP spectra and produce a high-resolution metallicity map of the SMC. Our metallicity gradient estimate of the SMC turns out to be --0.062 $\pm$ 0.009 dex/deg. This is comparable with the previous estimates, which also validate our method of metallicity estimation. We aim to apply this method to other stellar populations and to the LMC to create a high-resolution metallicity map of the Magellanic Clouds.Comment: 4 pages, 3 figures, Accepted for publication in proceedings of IAU Symposium 379: Dynamical Masses of Local Group Galaxie

Solitary angiokeratoma of tongue: A case report and review of the literature

Angiokeratoma is a benign cutaneous lesion of capillaries. It is characterized by large dilated blood vessels in the superficial dermis and hyperkeratosis of extremities. It is mostly seen in generalized form affecting the extremity of the body, but we report this case of solitary angiokeratoma of the tongue which is a very rare type

Mollification of doxorubicin (DOX)-mediated cardiotoxicity using conjugated chitosan nanoparticles with supplementation of propionic acid

Doxorubicin is an extensively prescribed antineoplastic agent. It is also known for adverse effects, among which cardiotoxicity tops the list. The possible mechanism underlying doxorubicin (DOX)-mediated cardiotoxicity has been investigated in this study. Further, to reduce the DOX-mediated cardiotoxicity, DOX was conjugated with Chitosan Nanoparticles (DCNPs) and supplemented with propionic acid. Initially, the drug loading efficacy and conjugation of DOX with chitosan was confirmed by UV-Visible Spectroscopy (UV) and Fourier Transform Infrared Spectroscopy (FTIR). The average sizes of the synthesized Chitosan Nanoparticles (CNPs) and DCNPs were measured by Dynamic Light Scattering (DLS) analysis as 187.9 ± 1.05 nm and 277.3 ± 8.15 nm, respectively, and the zeta potential values were recorded as 55.2 ± 0.7 mV and 51.9 ± 1.0 mV, respectively. The size and shape of CNPs and DCNPs were recorded using a High-Resolution Electron Microscopy (HRTEM). The particles measured <30 nm and 33-84 nm, respectively. The toxic effects of DCNPs and propionic acid were evaluated in rat model. The data from the electrocardiogram (ECG), cardiac biomarkers, Peroxisome proliferator-activated receptor gamma (PPARγ) and histological observations indicated evidence of DOX-mediated cardiotoxicity, whereas the administration of DCNPs, as well as Propionic Acid (PA), brought about a restoration to normalcy and offered protection in the context of DOX-induced cardiotoxicity.Published versionIndian Council of Medical Research: 5/10FR/84/2020-RBMCH