52 research outputs found
Minimal dataset for post-registration surveillance of new drugs in hemophilia: communication from the SSC of the ISTH
Clinical epidemiolog
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Executive Summary: Heart Disease and Stroke Statistics-2015 Update A Report From the American Heart Association
Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes : a retrospective multicenter study of the European Society of Blood and Marrow Transplantation
The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database. A total of 903 patients had sufficient cytogenetic information available at stem cell transplantation to be classified according to the 5-group classification. Poor and very poor risk according to this classification was an independent predictor of shorter relapse-free survival (hazard ratio 1.40 and 2.14), overall survival (hazard ratio 1.38 and 2.14), and significantly higher cumulative incidence of relapse (hazard ratio 1.64 and 2.76), compared to patients with very good, good or intermediate risk. When comparing the predictive performance of a series of Cox models both for relapse-free survival and for overall survival, a model with simplified 5-group cytogenetics (merging very good, good and intermediate cytogenetics) performed best. Furthermore, monosomal karyotype is an additional negative predictor for outcome within patients of the poor, but not the very poor risk group of the 5-group classification. The revised International Prognostic Scoring System cytogenetic classification allows patients with myelodysplastic syndromes to be separated into three groups with clearly different outcomes after stem cell transplantation. Poor and very poor risk cytogenetics were strong predictors of poor patient outcome. The new cytogenetic classification added value to prediction of patient outcome compared to prediction models using only traditional risk factors or the 3-group International Prognostic Scoring System cytogenetic classification.Peer reviewe
Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH
Thrombosis and Hemostasi
Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization
Stemcel biology/Regenerative medicine (incl. bloodtransfusion
Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH
Thrombosis and Hemostasi
International Collaborative Study for the Calibration of a Proposed International Standard for thromboplastin, human, plain
Thrombosis and Hemostasi
Design of clinical trials for new products in hemophilia: communication from the SSC of the ISTH
Thrombosis and Hemostasi
Disease prevalence dependent failure rate in diagnostic management studies on suspected deep vein thrombosis: communication from the SSC of the ISTH
Thrombosis and Hemostasi
Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH
Thrombosis and Hemostasi
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