Spectral Decomposition of the Tent Map with Varying Height

The generalized spectral decomposition of the Frobenius-Perron operator of the tent map with varying height is determined at the band-splitting points. The decomposition includes both decay onto the attracting set and the approach to the asymptotically periodic state on the attractor. Explicit compact expressions for the polynomial eigenstates are obtained using algebraic techniques.Comment: 39 pages, 7 figures, in LATeX with embedded PS figure

Backward whirl in a simple rotor supported on hydrodynamic bearings

The asymmetric nature of the fluid film stiffness and damping properties in rotors supported on fluid film bearings causes a forward or a backward whirl depending on the bearing parameters and the speed of the rotor. A rotor was designed to exhibit backward synchronous whirl. The rotor-bearing system exhibited split criticals, and a backward whirl was observed between the split criticals. The orbital diagrams show the whirl pattern

H-E-Super Magic Decomposition of Graphs

An H-magic labeling in an H-decomposable graph G is a bijection f:V(G) U E(G) --> {1,2, … ,p+q} such that for every copy H in the decomposition, $\sum\limits_{v\in V(H)} f(v)+\sum\limits_{e\in E(H)} f(e)$ is constant. The function f is said to be H-E-super magic if f(E(G)) = {1,2, … ,q}. In this paper, we study some basic properties of m-factor-E-super magic labelingand we provide a necessary and sufficient condition for an even regular graph to be 2-factor-E-super magic decomposable. For this purpose, we use Petersen\u27s theorem and magic squares

Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials.

PurposePatients with advanced cholangiocarcinoma (CC) and gallbladder carcinoma (GC) have few therapeutic options for relapsed disease. methods: Given the overall poor prognosis in this population and the availability of novel targeted therapies, we systematically analyzed the characteristics and outcomes for GC and CC patients treated on phase I trials with an emphasis on targeted agents and locoregional therapies.ResultsOf 40 treated patients (GC=6; CC=34; median age, 60 years), 8 (20%) had stable disease (SD) > 6 months, 3 (8%) partial response (PR), on protocols with hepatic arterial drug infusion and anti-angiogenic, anti-HER-2/neu or novel MAPK/ERK kinase (MEK) inhibitors. Median progression-free survival (PFS) on phase I trials was 2.0 months (95% CI 1.7, 2.8) versus 3.0 months (95% CI 2.4, 5.0), 3.0 months (95% CI 2.3, 4.6), and 3.0 months (95% CI 2.4, 3.9) for their first-, second-, and last-line FDA-approved therapy. In univariate analysis, >3 metastatic sites, elevated alanine aminotransferase (ALT) (>56IU/L), serum creatinine (>1.6mg/dL), and CA19-9 (>35U/mL) were associated with a shorter PFS. Mutational analysis revealed mutation in the KRAS oncogene in 2 of 11 patients (18%). The SD >6 months/PR rate of 28% was seen with hepatic arterial infusion of oxaliplatin, and inhibitors of angiogenesis, HER-2/neu or MEK.ConclusionsThe PFS in phase I trials was similar to that of the first, second, and last-line therapy (P=0.95, 0.98, 0.76, respectively) with FDA-approved agents given in the advanced setting, emphasizing a role for targeted agents in a clinical trials setting as potentially valuable therapeutic options for these patients

Separation and identification of indene-C70 bisadduct isomers.

Following an initial work on the isolation of a single geometric isomer from an indene-C70 bisadduct (IC70BA) mixture, we report the full fractionation and identification of the bisadduct species in the material. Eleven fractions of IC70BA isomers were separated by high-performance liquid chromatography. A number of fractions contained relatively pure isomer species and their configuration were deduced using a variety of analytical techniques including (1)H and (13)C NMR and UV-vis spectroscopy. The electrochemical properties and the organic solar cell device performance were investigated for fractions where a reasonable quantity of sample could be isolated

Stability improvement of an efficient graphene nanoribbon field-effect transistor-based sram design

The development of the nanoelectronics semiconductor devices leads to the shrinking of transistors channel into nanometer dimension. However, there are obstacles that appear with downscaling of the transistors primarily various short-channel effects. Graphene nanoribbon field-effect transistor (GNRFET) is an emerging technology that can potentially solve the issues of the conventional planar MOSFET imposed by quantum mechanical (QM) effects. GNRFET can also be used as static random-access memory (SRAM) circuit design due to its remarkable electronic properties. For high-speed operation, SRAM cells are more reliable and faster to be effectively utilized as memory cache. The transistor sizing constraint affects conventional 6T SRAM in a trade-off in access and write stability. This paper investigates on the stability performance in retention, access, and write mode of 15 nm GNRFET-based 6T and 8T SRAM cells with that of 16 nm FinFET and 16 nm MOSFET. The design and simulation of the SRAM model are simulated in synopsys HSPICE. GNRFET, FinFET, and MOSFET 8T SRAM cells give better performance in static noise margin (SNM) and power consumption than 6T SRAM cells. The simulation results reveal that the GNRFET, FinFET, and MOSFET-based 8T SRAM cells improved access static noise margin considerably by 58.1%, 28%, and 20.5%, respectively, as well as average power consumption significantly by 97.27%, 99.05%, and 83.3%, respectively, to the GNRFET, FinFET, and MOSFET-based 6T SRAM design. © 2020 Mathan Natarajamoorthy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Transparent metal electrodes from ordered nanosphere arrays

We show that perforated metal electrode arrays, fabricated using nanosphere lithography, provide a viable alternative to conductive metal oxides as transparent electrode materials. The inter-aperture spacing is tuned by varying etching times in an oxygen plasma, and the effect of inter-aperture “wire” thickness on the optical and electronic properties of perforated silver films is shown. Optical transmission is limited by reflection and surface plasmons, and for these results do not exceed 73%. Electrical sheet resistance is shown to be as low as 3 Ω ◻−1 for thermally evaporated silver films. The performance of organic photovoltaic devices comprised of a P3HT:PCBM bulk heterojunction deposited onto perforated metal arrays is shown to be limited by optical transmission, and a simple model is presented to overcome these limitations

Scanning Tunneling Microscope Images of Adenine and Thymine at Atomic Resolution

The scanning tunneling microscope has been used to obtain images of DNA that reveal its major and minor grooves and the direction of helical coiling, but sufficient resolution has not yet been achieved to identify its bases. To determine if this technology is capable of identifying individual DNA bases, we have examined the molecular arrangements of adenine and thymine attached to the basal plane of highly oriented pyrolytic graphite. Both molecules form highly organized lattices following deposition on heated graphite. Lattice dimensions, structural periodicities, and the epitaxy of adenine and thymine molecules with respect to the basal plane of graphite have been determined. Images of these molecules at atomic resolution reveal that the aromatic regions are strongly detected in both molecules while the various side-groups are not well-resolved. These studies provide the first evidence that tunneling microscopy can be used to discriminate between purines and pyrimidines

Splinters in the fingernails, heart and brain: thromboembolic complications of non-bacterial thrombotic endocarditis despite treatment with a direct-acting oral anticoagulant

Non-bacterial thrombotic endocarditis (NBTE) is a rare condition characterized by non-infectious vegetations affecting the cardiac valves. Although systemic thromboembolism is a commonly associated condition, antiphospholipid syndrome is less common. Nevertheless, treatment generally involves long-term anticoagulation. We report a case of a patient with previously undiagnosed NBTE who suffered systemic thromboembolic events despite pre-existing treatment with a direct-acting oral anticoagulant