832 research outputs found
Inhibition of ribosomal RNA synthesis without accumulation of guanosinetetraphosphate
Inhibition of ribosomal RNA synthesi
Effects of glucagon on the growth of Neurospora
Effects of glucagon on the growth of Neurospora
Complete phenomenological gravitational waveforms from spinning coalescing binaries
The quest for gravitational waves from coalescing binaries is customarily
performed by the LIGO-Virgo collaboration via matched filtering, which requires
a detailed knowledge of the signal. Complete analytical coalescence waveforms
are currently available only for the non-precessing binary systems. In this
paper we introduce complete phenomenological waveforms for the dominant
quadrupolar mode of generically spinning systems. These waveforms are
constructed by bridging the gap between the analytically known inspiral phase,
described by spin Taylor (T4) approximants in the restricted waveform
approximation, and the ring-down phase through a phenomenological intermediate
phase, calibrated by comparison with specific, numerically generated waveforms,
describing equal mass systems with dimension-less spin magnitudes equal to 0.6.
The overlap integral between numerical and phenomenological waveforms ranges
between 0.95 and 0.99.Comment: Proceeding for the GWDAW-14 conference. Added reference in v
Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the Ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1
We used yeast "two-hybrid" screening to isolate cDNA-encoding proteins interacting with the N-terminal domain of the Ras nucleotide exchange factor CDC25(Mm). Three independent overlapping clones were isolated from a mouse embryo cDNA library. The full-length cDNA was cloned by RACE-polymerase chain reaction. It encodes a large protein (1080 amino acids) highly homologous to the human deubiquitinating enzyme hUBPy and contains a well conserved domain typical of ubiquitin isopeptidases. Therefore we called this new protein mouse UBPy (mUBPy). Northern blot analysis revealed a 4-kilobase mRNA present in several mouse tissues and highly expressed in testis; a good level of expression was also found in brain, where CDC25(Mm) is exclusively expressed. Using a glutathione S-transferase fusion protein, we demonstrated an "in vitro" interaction between mUBPy and the N-terminal half (amino acids 1-625) of CDC25(Mm). In addition "in vivo" interaction was demonstrated after cotransfection in mammalian cells. We also showed that CDC25Mm, expressed in HEK293 cells, is ubiquitinated and that the coexpression of mUBPy decreases its ubiquitination. In addition the half-life of CDC25Mm protein was considerably increased in the presence of mUBPy. The specific function of the human homolog hUBPy is not defined, although its expression was correlated with cell proliferation. Our results suggest that mUBPy may play a role in controlling degradation of CDC25(Mm), thus regulating the level of this Ras-guanine nucleotide exchange factor
All-sky search of NAUTILUS data
A search for periodic gravitational-wave signals from isolated neutron stars
in the NAUTILUS detector data is presented. We have analyzed half a year of
data over the frequency band Hz/s and over the entire sky. We have divided the
data into 2 day stretches and we have analyzed each stretch coherently using
matched filtering. We have imposed a low threshold for the optimal detection
statistic to obtain a set of candidates that are further examined for
coincidences among various data stretches. For some candidates we have also
investigated the change of the signal-to-noise ratio when we increase the
observation time from two to four days. Our analysis has not revealed any
gravitational-wave signals. Therefore we have imposed upper limits on the
dimensionless gravitational-wave amplitude over the parameter space that we
have searched. Depending on frequency, our upper limit ranges from to . We have attempted a statistical
verification of the hypotheses leading to our conclusions. We estimate that our
upper limit is accurate to within 18%.Comment: LaTeX, 12 page
Next to leading order spin-orbit effects in the motion of inspiralling compact binaries
Using effective field theory (EFT) techniques we calculate the
next-to-leading order (NLO) spin-orbit contributions to the gravitational
potential of inspiralling compact binaries. We use the covariant spin
supplementarity condition (SSC), and explicitly prove the equivalence with
previous results by Faye et al. in arXiv:gr-qc/0605139. We also show that the
direct application of the Newton-Wigner SSC at the level of the action leads to
the correct dynamics using a canonical (Dirac) algebra. This paper then
completes the calculation of the necessary spin dynamics within the EFT
formalism that will be used in a separate paper to compute the spin
contributions to the energy flux and phase evolution to NLO.Comment: 25 pages, 4 figures, revtex4. v2: minor changes, refs. added. To
appear in Class. Quant. Gra
IGEC2: A 17-month search for gravitational wave bursts in 2005-2007
We present here the results of a 515 days long run of the IGEC2 observatory,
consisting of the four resonant mass detectors ALLEGRO, AURIGA, EXPLORER and
NAUTILUS. The reported results are related to the fourfold observation time
from Nov. 6 2005 until Apr. 14 2007, when Allegro ceased its operation. This
period overlapped with the first long term observations performed by the LIGO
interferometric detectors. The IGEC observations aim at the identification of
gravitational wave candidates with high confidence, keeping the false alarm
rate at the level of 1 per century, and high duty cycle, namely 57% with all
four sites and 94% with at least three sites in simultaneous observation. The
network data analysis is based on time coincidence searches over at least three
detectors: the four 3-fold searches and the 4-fold one are combined in a
logical OR. We exchanged data with the usual blind procedure, by applying a
unique confidential time offset to the events in each set of data. The
accidental background was investigated by performing sets of 10^8 coincidence
analyses per each detector configuration on off-source data, obtained by
shifting the time series of each detector. The thresholds of the five searches
were tuned so as to control the overall false alarm rate to 1/century. When the
confidential time shifts was disclosed, no gravitational wave candidate was
found in the on-source data. As an additional output of this search, we make
available to other observatories the list of triple coincidence found below
search thresholds, corresponding to a false alarm rate of 1/month.Comment: 10 pages, 8 figures Accepted for publication on Phys. Rev.
Status of NINJA: the Numerical INJection Analysis project
The 2008 NRDA conference introduced the Numerical INJection Analysis project (NINJA), a new collaborative effort between the numerical relativity community and the data analysis community. NINJA focuses on modeling and searching for gravitational wave signatures from the coalescence of binary system of compact objects. We review the scope of this collaboration and the components of the first NINJA project, where numerical relativity groups shared waveforms and data analysis teams applied various techniques to detect them when embedded in colored Gaussian noise
Results of the IGEC-2 search for gravitational wave bursts during 2005
The network of resonant bar detectors of gravitational waves resumed
coordinated observations within the International Gravitational Event
Collaboration (IGEC-2). Four detectors are taking part in this collaboration:
ALLEGRO, AURIGA, EXPLORER and NAUTILUS. We present here the results of the
search for gravitational wave bursts over 6 months during 2005, when IGEC-2 was
the only gravitational wave observatory in operation. The network data analysis
implemented is based on a time coincidence search among AURIGA, EXPLORER and
NAUTILUS, keeping the data from ALLEGRO for follow-up studies. With respect to
the previous IGEC 1997-2000 observations, the amplitude sensitivity of the
detectors to bursts improved by a factor about 3 and the sensitivity bandwidths
are wider, so that the data analysis was tuned considering a larger class of
detectable waveforms. Thanks to the higher duty cycles of the single detectors,
we decided to focus the analysis on three-fold observation, so to ensure the
identification of any single candidate of gravitational waves (gw) with high
statistical confidence. The achieved false detection rate is as low as 1 per
century. No candidates were found.Comment: 10 pages, to be submitted to Phys. Rev.
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