Análises de dados de negócio para orientar a tomada de decisões gerenciais em uma varejista do setor moveleiro.

TCC(graduação) - Universidade Federal de Santa Catarina, Centro Tecnológico, Engenharia de Produção.O mercado varejista é um pilar da economia nacional. No entanto, devido à falta de recursos disponíveis pelos empreendedores e da baixa escolaridade do setor, o uso de ferramentas computacionais para auxiliar no gerenciamento das empresas ainda é reservado a poucos negócios. Este trabalho visa contribuir no aprimoramento da gestão de uma varejista do setor moveleiro, através da utilização dos dados gerados pela mesma para orientar as tomadas de decisões gerenciais. Para isso, modelou-se um banco de dados relacional referente aos dados da empresa, inserindo nele os dados referentes ao período de janeiro de 2021 até agosto de 2022, definiu-se a maneira como os dados seriam mantidos atualizados dentro do banco de dados, segmentou-se os produtos comercializados em classes e utilizou-se da análise com a curva ABC sobre os dados referentes aos fornecedores e valor de venda da mercadoria. Por fim, modelou-se painéis interativos que possibilitam a verificação dos dados da empresa de maneira intuitiva para orientar as tomadas de decisões gerenciais. Os resultados obtidos através das análises mostram que muitos fornecedores e intervalos de valores de vendas não contribuem de maneira significativa para o lucro da empresa, e portanto à exceção dos casos que apresentem um fator estratégico que motive a comercialização dos produtos de tais fornecedores e intervalos de valores, orienta-se que seja descontinuada a comercialização dos demais produtos que apresentem esse perfil.The retail market is a pillar of the national economy. However, due to the lack of resources available to entrepreneurs and the low level of education in the sector, the use of computer tools to assist in the management of companies is still reserved to a few businesses. This work aims to contribute to the improvement of the management of a retailer of the furniture sector, through the use of data generated by it to guide managerial decision making. To do this, we modeled a relational database with the company’s data, inserting in it data referring to the period from January 2021 to August 2022, then it was defined how the data would be kept updated within the database. The commercialized products were segmented into classes and used the analysis with the ABC curve on the data referring to suppliers and sales value of the goods. Finally, interactive dashboards were modeled that make it possible to analyze the company’s data in an intuitive manner to guide management decision making. The results obtained from the analyses show that many suppliers and sales value ranges do not contribute in a significant way to the company’s profit, and therefore except in cases that present a strategic factor that motivates the marketing of products from such suppliers and value ranges, it is recommended that the commercialization of the other products that present this profile be discontinued

Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review

Background: Recurrent acute respiratory tract infections (ARTI) are a common problem in childhood. Some evidence suggests a benefit regarding the prevention of ARTI in children treated with the immunomodulator OM-85 BV (Bronchovaxom). Methods: We summarised the evidence on the effectiveness of the immunomodulator OM-85 BV in the prevention of ARTI in children. We searched randomised comparisons of oral purified bacterial extracts against inactive controls in children with respiratory tract diseases in nine electronic databases and reference lists of included studies. We extracted salient features of each study, calculated relative risks (RR) or weighted mean differences (WMD) and performed meta-analyses using random-effects models. Results: Thirteen studies (2,721 patients) of low to moderate quality tested OM-85 BV. Patients and outcomes differed substantially, which impeded pooling results of more than two trials. Two studies (240 patients) reporting on the number of patients with less than three infections over 6 month of follow-up in children not in day care showed a trend for benefit RR 0.82 (95% CI, 0.65-1.02). One out of two studies examining the number of children not in day care without infections over 4-6 month reported a significant RR of 0.42 (95% CI, 0.21-0.82) whereas the smaller, second study did not [RR 0.92 (95% CI, 0.58-1.46)]. Two studies reporting the number of antibiotic courses indicated a benefit for the intervention arm [WMD 2.0 (95% CI, 1.7-2.3)]. Two out of the three studies showed a reduction of length of episodes of 4-6 days whereas a third study showed no difference between the two groups. Conclusion: Evidence in favour of OM-85 BV in the prevention of ARTI in children is weak. There is a trend for fewer and shorter infections and a reduction of antibiotic us

Employee skills for circular business model implementation: A taxonomy

A growing body of scholarship has examined circular business models as a pathway towards sustainability. However, employee skills to support such business models have been largely overlooked. Addressing this research gap, this article proposes a comprehensive skill taxonomy for start-ups embracing circular economy transition. As the first large-N effort to develop a comprehensive skill taxonomy for circular business model implementation, this study uses a clustering analysis of self-reported skill profiles for 2407 staff working in circular start-ups. The taxonomy outlines 40 skills across six categories: business innovation, operations, social dimensions, systems, digitization, and technical issues. Findings suggest that circular business model implementation requires a set of general, sustainable, and circular skills, but some of these skills have been neglected in scholarship. Promoting circular narratives as a framing device for skill development can help advance CE towards mainstream uptake, and this study's taxonomy offers a practical framework for using talent to accelerate CE transition

SUSY GUTs with Yukawa unification: a go/no-go study using FCNC processes

We address the viability of exact Yukawa unification in the context of general SUSY GUTs with universal soft-breaking sfermion and gaugino mass terms at the GUT scale. We find that this possibility is challenged, unless the squark spectrum is pushed well above the limits allowed by naturalness. This conclusion is assessed through a global fit using electroweak observables and quark flavour-changing neutral current (FCNC) processes. The problem is mostly the impossibility of accommodating simultaneously the bottom mass and the BR(B --> Xs gamma), after the stringent CDF upper bound on the decay Bs --> mu^+ mu^- is taken into account, and under the basic assumption that the b --> s gamma amplitude have like sign with respect to the Standard Model one, as indicated by the B --> Xs l^+ l^- data. With the same strategy, we also consider the possibility of relaxing Yukawa unification to b - tau Yukawa unification. We find that with small departures from the condition tan beta ~= 50, holding when Yukawa unification is exact, the mentioned tension is substantially relieved. We emphasize that in the region where fits are successful the lightest part of the SUSY spectrum is basically fixed by the requirements of b - tau unification and the applied FCNC constraints. As such, it is easily falsifiable once the LHC turns on.Comment: 10 pages, 1 figure, 5 tables. v3: A few textual modifications. Conclusions unchanged. Matches journal versio

StrainGE: A toolkit to track and characterize low-abundance strains in complex microbial communities

Human-associated microbial communities comprise not only complex mixtures of bacterial species, but also mixtures of conspecific strains, the implications of which are mostly unknown since strain level dynamics are underexplored due to the difficulties of studying them. We introduce the Strain Genome Explorer (StrainGE) toolkit, which deconvolves strain mixtures and characterizes component strains at the nucleotide level from short-read metagenomic sequencing with higher sensitivity and resolution than other tools. StrainGE is able to identify strains at 0.1x coverage and detect variants for multiple conspecific strains within a sample from coverages as low as 0.5x

Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives

Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favourable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis

Highlights from the Pierre Auger Observatory

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 201

Restructuring of Pancreatic Islets and Insulin Secretion in a Postnatal Critical Window

Function and structure of adult pancreatic islets are determined by early postnatal development, which in rats corresponds to the first month of life. We analyzed changes in blood glucose and hormones during this stage and their association with morphological and functional changes of alpha and beta cell populations during this period. At day 20 (d20), insulin and glucose plasma levels were two- and six-fold higher, respectively, as compared to d6. Interestingly, this period is characterized by physiological hyperglycemia and hyperinsulinemia, where peripheral insulin resistance and a high plasmatic concentration of glucagon are also observed. These functional changes were paralleled by reorganization of islet structure, cell mass and aggregate size of alpha and beta cells. Cultured beta cells from d20 secreted the same amount of insulin in 15.6 mM than in 5.6 mM glucose (basal conditions), and were characterized by a high basal insulin secretion. However, beta cells from d28 were already glucose sensitive. Understanding and establishing morphophysiological relationships in the developing endocrine pancreas may explain how events in early life are important in determining adult islet physiology and metabolism

Games used with serious purposes: a systematic review of interventions in patients with cerebral palsy

The purpose of the present systematic review was to examine extant research regarding the role of games used seriously in interventions with individuals with cerebral palsy. Therefore, PubMed, PsyINFO, Web of Science, Scopus, and IEEE databases were used. Search terms included: "serious games" OR "online games" OR "video games" OR "videogame" OR "game based" OR "game" AND "intervention" AND "cerebral palsy." After the full reading and quality assessment of the papers, 16 studies met the inclusion criteria. The majority of the studies reported high levels of compliance, motivation, and engagement with game-based interventions both at home and at the clinical setting intervention. Regarding the effectiveness of the use of games, the results of the studies show both positive and negative results regarding their effectiveness. The efficacy was reported to motor function (i.e., improvements in the arm function, hand coordination, functional mobility, balance and gait function, postural control, upper-limbs function) and physical activity. Findings of this review suggest that games are used as a complement to conventional therapies and not as a substitute. Practitioners often struggle to get their patients to complete the assigned homework tasks, as patients display low motivation to engage in prescribed exercises. Data of this review indicates the use of games as tools suited to promote patients' engagement in the therapy and potentiate therapeutic gains.This study was conducted at Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). SL and AP were supported by a Ph.D. fellowship from the Portuguese Foundation for Science and Technology (FCT). PM was supported by a Post-Doctoral fellowship from the Psychology Research Centre (CIPsi), University of Minho. JM was supported by a research scholarship from the Psychology Research Centre (CIPsi), University of Minho