341 research outputs found
Dopamine Receptors in Parkinson's Disease: A Meta-Analysis of Imaging Studies
AbstractDopamine receptors are abundant along the central nigrostriatal tract and are expressed as 5 subtypes in two receptor families. In PD, compensatory changes in dopamine receptors emerge as a consequence of the loss of dopamine nerve terminals or dopaminergic pharmacotherapy. We performed a systematic review and metaâanalysis of the available PET and singleâphoton emission computed tomography studies that have investigated dopamine receptors in PD, PSP and MSA. The inclusion criteria were studies including human PET or singleâphoton emission computed tomography imaging; dopamine receptor tracers (D1âlike or D2âlike) and idiopathic PD, PSP, or MSA patients compared with healthy controls. The 67 included D2âlike studies had 1925 patients. Data were insufficient for an analysis of D1âlike studies. PD patients had higher striatal binding early in the disease, but after a disease duration of 4.36âyears, PD patients had lower binding values than healthy controls. Striatal D2R binding was highest in unmedicated early PD patients and in the striatum contralateral to the predominant motor symptoms. PSP and MSAâP patients had lower striatal D2R binding than PD patients (14.2% and 21.8%, respectively). There is initial upregulation of striatal D2Rs in PD, which downregulate on average 4âyears after motor symptom onset, possibly because of agonistâinduced effects. The consistent upregulation of D2Rs in the PD striatum contralateral to the predominant motor symptoms indicates that receptor changes are driven by neurodegeneration and loss of striatal neuropil. Both PSP and MSA patients have clearly lower striatal D2R binding values than PD patients, which offers an opportunity for differential diagnostics. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Societ
Validation of the 3-under-2 principle of cell wall growth in Gram-positive bacteria by simulation of a simple coarse-grained model
The aim of this work is to propose a first coarse-grained model of Bacillus
subtilis cell wall, handling explicitly the existence of multiple layers of
peptidoglycans. In this first work, we aim at the validation of the recently
proposed "three under two" principle.Comment: Revised introduction, results unchange
15-15Ti(Si) austenitic steel: Creep behaviour in hostile environment
This work aims at studying the creep behaviour of 15-15Ti(Si) austenitic steel, under uniaxial stress (range of 300-560 MPa), and its interaction with liquid lead. The steel was tested to verify its sensitivity to Liquid Metal Embrittlement (LME) and to simulate its behaviour in operating thermal and mechanical stress conditions of the IV generation Lead-cooled fast reactor. The experimental results permitted to plot the time-strain creep curve and the characteristic Norton-based curve, simulating the creep behaviour at all stress values. The comparison between the creep curves in air and in lead showed that the LME produces a decrease of creep-rupture time, a reduction of creep strain and then the loss of steel ductility. Moreover, the raw material and fracture surfaces were analyzed by Optical Microscope and Scanning Electron Microscope (SEM). SEM micrographs highlighted that lead changes both the mode and the type of specimen fracture. In addition, it was analyzed the lead action time, as the time after which the corrosion appears with macroscopic effects. Although some tests are still ongoing, it can be assumed that at high stresses, LME takes place after a long time of steel/lead contact while at low stresses, LME tends to prevail on creep effect
Decapod crustaceans associated with an artificial reef (Adriatic Sea)
The aim of this study is to increase the knowledge on the distribution of decapod crustaceans associated with an artificial reef positioned on sandy-mud bottoms in the central Adriatic Sea. The reef is constituted of concrete modules assembled in pyramids and concrete poles. Hard and soft bottom samples were collected from 2001, just after reef construction, to 2005 (4 surveys per year). Regarding the soft seabed, three sites close to a pyramid, three inside the reef area at a distance of 10-15 m from the structures, and three 200 m outside the reef (control sites) were randomly sampled during each survey. At the same time, three pyramids (vertical and horizontal walls) and three poles were also investigated. After taxonomical analysis, decapod crustaceans were analysed using abundance and species richness. Sites and years were compared using a balanced, fixed effect, 2-way ANOVA and PERMANOVA. In addition, SIMPER analysis was performed to identify those species typifying each community inhabiting both the soft bottom and the artificial substrates. The results showed that the artificial reef induced an increase in both abundance and diversity of the decapods of the natural habitat. In fact, man-made substrates may offer new available space for biological colonization and allow the settlement of new species usually living on hard bottoms, thus increasing the complexity of the original benthic communities
Immunomodulatory drugs in acute myeloid leukemia treatment
Immunomodulatory drugs (IMiDs) are analogs of thalidomide. They have immunomodulatory, antiangiogenic and proapoptotic properties and exert a role in regulating the tumor microenvironment. Recently IMiDs have been investigated for their pleiotropic properties and their therapeutic applications in both solid tumors (melanoma, prostate carcinoma and differentiated thyroid cancer) and hematological malignancies. Nowadays, they are applied in de novo and relapsed/ refractory multiple myeloma, in myelodysplastic syndrome, in del5q syndrome with specific use of lenalidomide and B-cell lymphoma. Several studies have been conducted in the last few years to explore IMiDs possible use in acute myeloid leukemia treatment. Here we report the mechanisms of action of IMiDs in acute myeloid leukemia and their potential future therapeutic application in this disease
Direct Estimate of Cirrus Noise in Herschel Hi-GAL Images
In Herschel images of the Galactic plane and many star forming regions, a
major factor limiting our ability to extract faint compact sources is cirrus
confusion noise, operationally defined as the "statistical error to be expected
in photometric measurements due to confusion in a background of fluctuating
surface brightness". The histogram of the flux densities of extracted sources
shows a distinctive faint-end cutoff below which the catalog suffers from
incompleteness and the flux densities become unreliable. This empirical cutoff
should be closely related to the estimated cirrus noise and we show that this
is the case. We compute the cirrus noise directly, both on Herschel images from
which the bright sources have been removed and on simulated images of cirrus
with statistically similar fluctuations. We connect these direct estimates with
those from power spectrum analysis, which has been used extensively to predict
the cirrus noise and provides insight into how it depends on various
statistical properties and photometric operational parameters. We report
multi-wavelength power spectra of diffuse Galactic dust emission from Hi-GAL
observations at 70 to 500 microns within Galactic plane fields at l= 30 degrees
and l= 59 degrees. We find that the exponent of the power spectrum is about -3.
At 250 microns, the amplitude of the power spectrum increases roughly as the
square of the median brightness of the map and so the expected cirrus noise
scales linearly with the median brightness. Generally, the confusion noise will
be a worse problem at longer wavelengths, because of the combination of lower
angular resolution and the rising power spectrum of cirrus toward lower spatial
frequencies, but the photometric signal to noise will also depend on the
relative spectral energy distribution of the source compared to the cirrus.Comment: 4 pages (in journal), 3 figures, Astronomy and Astrophysics, accepted
for publication 13 May 201
Characterizing the structure of diffuse emission in Hi-GAL maps
We present a study of the structure of the Galactic interstellar medium
through the Delta-variance technique, related to the power spectrum and the
fractal properties of infrared/sub-mm maps. Through this method, it is possible
to provide quantitative parameters which are useful to characterize different
morphological and physical conditions, and to better constrain the theoretical
models. In this respect, the Herschel Infrared Galactic Plane Survey carried
out at five photometric bands from 70 to 500 \mu m constitutes an unique
database for applying statistical tools to a variety of regions across the
Milky Way. In this paper, we derive a robust estimate of the power-law portion
of the power spectrum of four contiguous 2{\deg}x2{\deg} Hi-GAL tiles located
in the third Galactic quadrant (217{\deg} < l < 225{\deg}, -2{\deg} < b <
0{\deg}). The low level of confusion along the line of sight testified by CO
observations makes this region an ideal case. We find very different values of
the power spectrum slope from tile to tile but also from wavelength to
wavelength (2 < \beta < 3), with similarities between fields attributable to
components located at the same distance. Thanks to the comparison with models
of turbulence, an explanation of the determined slopes in terms of the fractal
geometry is also provided, and possible relations with the underlying physics
are investigated. In particular, an anti-correlation between ISM fractal
dimension and star formation efficiency is found for the two main distance
components observed in these fields. A possible link between the fractal
properties of the diffuse emission and the resulting clump mass function is
discussed.Comment: Accepted by Ap
Analysis and performance assessment of the use of ammonia-based nano additive for lean combustion
In recent years, considerable progress has been made in exploring new applications of fuel additives to reduce emissions. Reduction of total nitrogen oxide (NOx) emissions can be achieved by decreasing the flame temperature by using fuel emulsified with water and/or using ammonia-based nano additives such as urea. The use of water as part of the hydrocarbon fuel is also one of the prospective directions in the development of new types of fuel systems. For the preparation of emulsified fuel, it is desirable to achieve greater stability of the emulsified fuel with minimum expenditure of chemicals and energy, so that the emulsified fuel can be used for a longer period. The paper analyzed the influence of nano-dispersed urea particles, water, and surfactant (Span 80/ Tween 80) on the combustion stability and emission characteristics of aviation fuel. The experimental campaign was conducted on a test stand (a 300kW liquid vortex combustor of 300 kW) consisting of a cylindrical combustion chamber with four optical windows
and equipped with high-precision pressure sensors, thermocouples, and an exhaust gas analyzer for acquiring emissions. The experimental campaign was conducted at a constant fuel/air ratio (Ί). One of the main focus is related to the stability of the emulsion. Chemiluminescence imaging was performed to characterize the effects of the additive on flame emissions. In addition, a statistical and spectral analysis was performed using the pressure sensor for instability analysis. Exhaust gas analysis was performed both with the additive described above and without additive for a constant Ί condition. The analysis was performed for NOx, carbon monoxide (CO) and carbon dioxide (CO2) and oxygen (O 2)
Analysis of Variance in Neuroreceptor Ligand Imaging Studies
Radioligand positron emission tomography (PET) with dual scan paradigms can provide valuable insight into changes in synaptic neurotransmitter concentration due to experimental manipulation. The residual t-test has been utilized to improve the sensitivity of the t-test in PET studies. However, no further development of statistical tests using residuals has been proposed so far to be applied in cases when there are more than two conditions. Here, we propose the residual f-test, a one-way analysis of variance (ANOVA), and examine its feasibility using simulated [11C]raclopride PET data. We also re-visit data from our previously published [11C]raclopride PET study, in which 10 individuals underwent three PET scans under different conditions. We found that the residual f-test is superior in terms of sensitivity than the conventional f-test while still controlling for type 1 error. The test will therefore allow us to reliably test hypotheses in the smaller sample sizes often used in explorative PET studies
<i>Herschel</i> observations of B1-bS and B1-bN: two first hydrostatic core candidates in the Perseus star-forming cloud
We report far-infrared Herschel observations obtained between 70 ÎŒm and 500 ÎŒm of two star-forming dusty condensations, [HKM99] B1-bS and [HKM99] B1-bN, in the B1 region of the Perseus star-forming cloud. In the western part of the Perseus cloud, B1-bS is the only source detected in all six PACS and SPIRE photometric bands, but it is not visible in the Spitzer map at 24 ÎŒm. B1-bN is clearly detected between 100 ÎŒm and 250 ÎŒm. We have fitted the spectral energy distributions of these sources to derive their physical properties, and find that a simple greybody model fails to reproduce the observed spectral energy distributions. At least a two-component model is required, consisting of a central source surrounded by a dusty envelope. The properties derived from the fit, however, suggest that the central source is not a Class 0 object. We then conclude that while B1-bS and B1-bN appear to be more evolved than a pre-stellar core, the best-fit models suggest that their central objects are younger than a Class 0 source. Hence, they may be good candidates to be examples of the first hydrostatic core phase. The projected distance between B1-bS and B1-bN is a few Jeans lengths. If their physical separation is close to this value, this pair would allow studying the mutual interactions between two forming stars at a very early stage of their evolution
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