26 research outputs found
Innate immunity glycoprotein gp-340 variants may modulate human susceptibility to dental caries
<p>Abstract</p> <p>Background</p> <p>Bacterial adhesion is an important determinant of colonization and infection, including dental caries. The salivary scavenger receptor cysteine-rich glycoprotein gp-340, which mediates adhesion of <it>Streptococcus mutans </it>(implicated in caries), harbours three major size variants, designated gp-340 I to III, each specific to an individual saliva. Here we have examined the association of the gp-340 I to III polymorphisms with caries experience and adhesion of <it>S. mutans</it>.</p> <p>Methods</p> <p>A case-referent study was performed in 12-year-old Swedish children with high (n = 19) or low (n = 19) caries experiences. We measured the gp-340 I to III saliva phenotypes and correlated those with multiple outcome measures for caries experience and saliva adhesion of <it>S. mutans </it>using the partial least squares (PLS) multivariate projection technique. In addition, we used traditional statistics and 2-year caries increment to verify the established PLS associations, and bacterial adhesion to purified gp-340 I to III proteins to support possible mechanisms.</p> <p>Results</p> <p>All except one subject were typed as gp-340 I to III (10, 23 and 4, respectively). The gp-340 I phenotype correlated positively with caries experience (VIP = 1.37) and saliva adhesion of <it>S. mutans </it>Ingbritt (VIP = 1.47). The gp-340 II and III phenotypes tended to behave in the opposite way. Moreover, the gp-340 I phenotype tended to show an increased 2-year caries increment compared to phenotypes II/III. Purified gp-340 I protein mediated markedly higher adhesion of <it>S. mutans </it>strains Ingbritt and NG8 and <it>Lactococcus lactis </it>expressing AgI/II adhesins (SpaP or PAc) compared to gp-340 II and III proteins. In addition, the gp-340 I protein appeared over represented in subjects positive for Db, an allelic acidic PRP variant associated with caries, and subjects positive for both gp-340 I and Db tended to experience more caries than those negative for both proteins.</p> <p>Conclusion</p> <p>Gp-340 I behaves as a caries susceptibility protein.</p
Manipulating and Mimicking Single-Cell Compartments Using Liposome Chemistry and Miniaturized Biomembrane Electropermeabilization
Foreign Language Learning : A study among Swedish children at school on how they learn English words and which learner strategies they use
Foreign Language Learning : A study among Swedish children at school on how they learn English words and which learner strategies they use
New Age & Christianity : a comparison
En jÀmförelse mellan New Age och kristendom som visar likheter och skillnader, samt en prövning efter en religionsdefinition
Livskvalitet hos kvinnor med bröstcancer som behandlats med mastektomi : En litteraturstudie
Introduktion: Bröstcancer Ă€r den vanligaste cancerformen hos kvinnor och utgör 30 procent av den totala diagnostiken. Mastektomi Ă€r en viktig behandling och innebĂ€r att hela bröstet opereras bort. Ă
r 2015 utfördes 3642 mastektomier i Sverige. Sjuksköterskan kan fungera som en stöttepelare i det postoperativa förloppet och för att kunna ge god vÄrd behövs kunskap om livskvaliteten hos de drabbade kvinnorna. Syfte: Syftet med litteraturstudien var att belysa livskvaliteten hos kvinnor med bröstcancer som behandlats med mastektomi. Metod: Litteraturstudien har genomförts enligt Polit och Becks (2017) niostegsmodell. En systematisk sökning i CINAHL och PubMed resulterade i litteraturstudiens första urval. Till urval 2 lÀstes artiklarna och valdes ut om de svarade mot syftet. Genom Polit och Becks (2017) granskningsmall granskades artiklar och till urval 3 kvarstod 11 artiklar dÀr alla var av kvantitativ metod. Resultat: Litteraturstudien resulterade i fem kategorier: Livskvalitet relaterat till den fysiska funktionen, Livskvalitet relaterat till den mentala funktionen, Livskvalitet relaterat till den sociala funktionen, Livskvalitet relaterat till den kroppsliga förÀndringen samt Global hÀlsa och hÀlsoprognos. Slutsats: Kvinnorna hade en varierande livskvalitet dÀr majoriteten hade en tydlig förbÀttring över tid.
Vad menar de egentligen? : En komparativ semantisk textanalys av nationella och lokala uppnÄendemÄl i moderna sprÄk i grundskolan
Syftet med denna studie var att undersöka hur den nationella kursplanen i moderna sprÄk Är nio kan tolkas i en lokal kursplan samt tolkningens konsekvenser för eleven i frÄga om kravnivÄ. Materialet bestod av en lokal kursplan samt den nationella kursplanen och det analyserades genom komparativ semantisk textanalys och encyklopedisk definition. Resultatet visade att den lokala tolkningen leder till förÀndring i betydelse och till förÀndrad kravnivÄ för eleven. Studiens resultat stödjer tidigare forskning som sÀger att lokala mÄlformuleringar Àr problematiska
Palliative key aspects are of importance for symptom relief during the last week of life in patients with heart failure
Aims: This study aimed to describe symptom prevalence of pain, shortness of breath, anxiety, and nausea and to identify factors associated with symptom relief in patients with heart failure during their last week of life. Methods and results: This nationwide study used data from the Swedish Register of Palliative Care and the Swedish Causes of Death Certificate Register. The sample included 4215 patients with heart failure as the underlying cause of death. Descriptive statistics and logistic regression were used to analyse data. Pain was the most prevalent symptom (64.0%), followed by anxiety (45.1%), shortness of breath (28.8%), and nausea (11.4%). Pain was the most often totally relieved (77.5%), followed by anxiety (68.4%), nausea (54.7%), and shortness of breath (37.1%). Key aspects of palliative care such as documented palliative care in the patient record, individual medication prescriptions by injection, symptom assessment with validated scales, documented endâofâlife discussions with patients and/or family members, and external consultation were significantly associated with symptom relief. Relief of pain, shortness of breath, anxiety, and nausea were significantly better managed in nursing homes and hospice/inpatient palliative care compared with care in hospitals. Conclusions: The results show that key aspects of palliative care during the last week of life are significantly associated with symptom relief. Increased access to palliative care could provide a way to improve care during the last week of life for patients with heart failure. Homeâbased settings provided more symptom relief than hospitals, which may indicate that the latter focuses on treatments and saving lives rather than promoting life before death