Quality and Environment management system

Tato práce je pojednáním o vztahu kvality a životního prostředí a jejich vzájemném ovlivňování. V první části je popsána jakost jako taková a jsou přiblíženy principy jejího dosahování. Je zde podrobněji rozebrán systém managementu jakosti. Druhá část je zaměřena na ekologii, přičemž důraz je kladen na výrobu a zohledňování životního prostředí, při snaze dosáhnout kvality produktu.This paper deals with interaction of quality and environment and their influence. The first part describes the quality itself and tries to explain how it works and how we can reach the quality. The focus of this description is on the Quality Management System. The second part of this paper deals with ecology and environment and focuses on the production and considers environment when trying to reach high quality of products.

Process performance planning

Tato diplomová práce se zabývá operativním plánováním výroby ve společnosti DT – Výhybkárna a strojírna, a.s., konkrétně pak vyhodnocením dopadů průchodu mimořádné zakázky výrobním procesem. Cílem je analýza současného stavu managementu procesů, vyhodnocení vlivu dodatečných zásahů do procesů a vyčíslení nákladů, které jsou s tímto zásahem do plánované výroby spojeny. Vše s ohledem na minimální náklady a maximální efektivitu při dané kvalitě. Výsledku je dosaženo pomocí simulací vložení mimořádné zakázky do podnikového informačního systému.This thesis deals with the operational planning of production at DT – Výhybkárna a strojírna, a.s., specifically evaluating impacts of the passage of an exceptional order on manufacturing process. Aim is to analyze the current state of process management, to evaluate the impact of additional interventions into the processes and to quantify the costs associated with this intervention in the planned production. All with the minimum cost and maximum efficiency at a given quality. The goal is achieved by simulating of inserting an exceptional order in the enterprise information system.

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients