Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression

<p><b>Background and Purpose:</b> Early clinical progression of ischemic stroke is common and is associated with increased risk of death and dependency. We hypothesized that activation of the coagulation system is an important contributor in some cases of deterioration. We aimed to characterize alterations in circulating hemostatic markers in patients with progressing stroke.</p> <p><b>Methods:</b> Consecutive acute ischemic stroke admissions were recruited. Progressing stroke was defined by deterioration in components of the Scandinavian Stroke Scale. Hemostatic markers (coagulation factors VIIc, VIIIc, and IXc, prothrombin fragments 1+2 [F1+2], thrombin-antithrombin complexes [TAT], D- dimer, fibrinogen, von Willebrand factor [vWF] and tissue plasminogen activator) were measured within 24 hours of symptom recognition.</p> <p><b>Results:</b> Fifty-four (25%) of the 219 patients met criteria for progressing stroke. F1+2 (median 1.28 versus 1.06 nmol/L, P=0.01), TAT (5.28 versus 4.07 mug/L, P lt 0.01), D-dimer ( 443 versus 194 ng/mL, P lt 0.001) and vWF (216 versus 198 IU/dL, P lt 0.05) levels were higher in these patients than in stable/improving patients. In logistic regression analysis, with all important clinical and laboratory variables included, only natural log D-dimer (odds ratio [OR]: 1.87; 95% confidence interval [CI]: 1.38 to 2.54; P=0.0001) and mean arterial blood pressure (OR: 1.26 per 10 mm Hg change; 95% CI: 1.05 to 1.51; P=0.01) remained independent predictors of progressing stroke.</p> <p><b>Conclusions:</b> There is evidence of excess thrombin generation and fibrin turnover in patients with progressing ischemic stroke. Measurement of D-dimer levels can identify patients at high risk for stroke progression. Further research is required to determine whether such patients benefit from acute interventions aimed at modifying hemostatic function.</p&gt

The evolutionary sequence of post-starburst galaxies

© 2017 The Authors. There are multiple ways in which to select post-starburst galaxies in the literature. In this work, we present a study into how two well-used selection techniques have consequences on observable post-starburst galaxy parameters, such as colour, morphology and environment, and how this affects interpretations of their role in the galaxy duty cycle. We identify a master sample of Hδ strong (EWHδ> 3Å) post-starburst galaxies from the value-added catalogue in the seventh data release of the Sloan Digital Sky Survey (SDSS DR7) over a redshift range 0.01 -2.5Å) but one having an additional cut onEWHα (> -3Å).We examine the differences in observables and AGN fractions to see what effect the Hα cut has on the properties of post-starburst galaxies and what these differing samples can tell us about the duty cycle of post-starburst galaxies. We find that Hδ strong galaxies peak in the 'blue cloud', E+As in the 'green valley' and pure E+As in the 'red sequence'.We also find that pure E+As have a more early-type morphology and a higher fraction in denser environments compared with the Hδ strong and E+A galaxies. These results suggest that there is an evolutionary sequence in the post-starburst phase from blue discy galaxies with residual star formation to passive red early-types

Environments and Morphologies of Red Sequence Galaxies with Residual Star Formation in Massive Clusters

We present a photometric investigation into recent star formation in galaxy clusters at z ~ 0.1. We use spectral energy distribution templates to quantify recent star formation in large X-ray selected clusters from the LARCS survey using matched GALEX NUV photometry. These clusters all have signs of red sequence galaxy recent star formation (as indicated by blue NUV-R colour), regardless of cluster morphology and size. A trend in environment is found for these galaxies, such that they prefer to occupy low density, high cluster radius environments. The morphology of these UV bright galaxies suggests that they are in fact red spirals, which we confirm with light curves and Galaxy Zoo voting percentages as morphological proxies. These UV bright galaxies are therefore seen to be either truncated spiral galaxies, caught by ram pressure in falling into the cluster, or high mass spirals, with the photometry dominated by the older stellar population.Comment: Accepted for publication in MNRAS, 11 pages, 11 figure

Detection of changes in temperature extremes during the second half of the 20th century

Since 1950, the warmest and coldest days and nights of the year have become warmer. Comparing these observations with climate model simulations in an optimal detection analysis shows a significant human influence on patterns of change in extremely warm nights. Human influence on cold nights and days is also detected, although less robustly, but there is no detection of a significant human influence on extremely warm days. In the future, extreme temperatures are expected to intensify considerably, with adverse consequences for human health

Use of high-dimensional spectral data to evaluate organic matter, reflectance relationships in soils

Recent breakthroughs in remote sensing technology have led to the development of a spaceborne high spectral resolution imaging sensor, HIRIS, to be launched in the mid-1990s for observation of earth surface features. The effects of organic carbon content on soil reflectance over the spectral range of HIRIS, and to examine the contributions of humic and fulvic acid fractions to soil reflectance was evaluated. Organic matter from four Indiana agricultural soils was extracted, fractionated, and purified, and six individual components of each soil were isolated and prepared for spectral analysis. The four soils, ranging in organic carbon content from 0.99 percent, represented various combinations of genetic parameters such as parent material, age, drainage, and native vegetation. An experimental procedure was developed to measure reflectance of very small soil and organic component samples in the laboratory, simulating the spectral coverage and resolution of the HIRIS sensor. Reflectance in 210 narrow (10 nm) bands was measured using the CARY 17D spectrophotometer over the 400 to 2500 nm wavelength range. Reflectance data were analyzed statistically to determine the regions of the reflective spectrum which provided useful information about soil organic matter content and composition. Wavebands providing significant information about soil organic carbon content were located in all three major regions of the reflective spectrum: visible, near infrared, and middle infrared. The purified humic acid fractions of the four soils were separable in six bands in the 1600 to 2400 nm range, suggesting that longwave middle infrared reflectance may be useful as a non-destructive laboratory technique for humic acid characterization

Octilinear Force-Directed Layout with Mental Map Preservation for Schematic Diagrams

We present an algorithm for automatically laying out metro map style schematics using a force-directed approach, where we use a localized version of the standard spring embedder forces combined with an octilinear magnetic force. The two types of forces used during layout are naturally conflicting, and the existing method of simply combining these to generate a resultant force does not give satisfactory results. Hence we vary the forces, emphasizing the standard forces in the beginning to produce a well distributed graph, with the octilinear forces becoming prevalent at the end of the layout, to ensure that the key requirement of line angles at intervals of 45? is obtained. Our method is considerably faster than the more commonly used search-based approaches, and we believe the results are superior to the previous force-directed approach. We have further developed this technique to address the issues of dynamic schematic layout. We use a Delaunay triangulation to construct a schematic “frame”, which is used to retain relative node positions and permits full control of the level of mental map preservation. This technique is the first to combine mental map preservation techniques with the additional layout criteria of schematic diagrams. To conclude, we present the results of a study to investigate the relationship between the level of mental map preservation and the user response time and accuracy

Risk factors for chest infection in acute stroke: a prospective cohort study

<p><b>Background and Purpose:</b> Pneumonia is a major cause of morbidity and mortality after stroke. We aimed to determine key characteristics that would allow prediction of those patients who are at highest risk for poststroke pneumonia.</p> <p><b>Methods:</b> We studied a series of consecutive patients with acute stroke who were admitted to hospital. Detailed evaluation included the modified National Institutes of Health Stroke Scale; the Abbreviated Mental Test; and measures of swallow, respiratory, and oral health status. Pneumonia was diagnosed by set criteria. Patients were followed up at 3 months after stroke.</p> <p><b>Results:</b> We studied 412 patients, 391 (94.9%) with ischemic stroke and 21 (5.1%) with hemorrhagic stroke; 78 (18.9%) met the study criteria for pneumonia. Subjects who developed pneumonia were older (mean±SD age, 75.9±11.4 vs 64.9±13.9 years), had higher modified National Institutes of Health Stroke Scale scores, a history of chronic obstructive pulmonary disease, lower Abbreviated Mental Test scores, and a higher oral cavity score, and a greater proportion tested positive for bacterial cultures from oral swabs. In binary logistic-regression analysis, independent predictors (P<0.05) of pneumonia were age >65 years, dysarthria or no speech due to aphasia, a modified Rankin Scale score ≥4, an Abbreviated Mental Test score <8, and failure on the water swallow test. The presence of 2 or more of these risk factors carried 90.9% sensitivity and 75.6% specificity for the development of pneumonia.</p> <p><b>Conclusions:</b> Pneumonia after stroke is associated with older age, dysarthria/no speech due to aphasia, severity of poststroke disability, cognitive impairment, and an abnormal water swallow test result. Simple assessment of these variables could be used to identify patients at high risk of developing pneumonia after stroke.</p&gt

Measurement of the intracluster light at z ~ 1

A significant fraction of the total photospheric light in nearby galaxy clusters is thought to be contained within the diffuse intracluster light (ICL), which extends 100s of kpc from cluster cores. The study of the ICL can reveal details of the evolutionary histories and processes occurring within galaxy clusters, however since it has a very low surface brightness it is often difficult to detect. We present here the first measurements of the ICL as a fraction of total cluster light at z \sim 1 using deep J-band (1.2 {\mu}m) imaging from HAWK-I on the VLT. We investigate the ICL in 6 X-ray selected galaxy clusters at 0.8< z <1.2 and find that the ICL below isophotes {\mu}(J) = 22 mag/arcsec2 constitutes 1-4% of the total cluster light within a radius R500. This is broadly consistent with simulations of the ICL at a similar redshift and when compared to nearby observations suggests that the fraction of the total cluster light that is in the ICL has increased by a factor 2 - 4 since z\sim1. We also find the fraction of the total cluster light contained within the Brightest Cluster Galaxy (BCG) to be 2.0-6.3% at these redshifts, which in 5 out of 6 cases is larger than the fraction of the ICL component, in contrast to results from nearby clusters. This suggests that the evolution in cluster cores involves substantial stripping activity at late times, in addition to the early build up of the BCG stellar mass through merging. The presence of significant amounts of stellar light at large radii from these BCGs may help towards solving the recent disagreement between the semi-analytic model predictions of BCG mass growth (e.g. De Lucia & Blaziot, 2007) and the observed large masses and scale sizes reported for BCGs at high redshift.Comment: 12 pages, 12 figures. Accepted for publication in MNRA

Simultaneous diagonalisation of the covariance and complementary covariance matrices in quaternion widely linear signal processing

Recent developments in quaternion-valued widely linear processing have established that the exploitation of complete second-order statistics requires consideration of both the standard covariance and the three complementary covariance matrices. Although such matrices have a tremendous amount of structure and their decomposition is a powerful tool in a variety of applications, the non-commutative nature of the quaternion product has been prohibitive to the development of quaternion uncorrelating transforms. To this end, we introduce novel techniques for a simultaneous decomposition of the covariance and complementary covariance matrices in the quaternion domain, whereby the quaternion version of the Takagi factorisation is explored to diagonalise symmetric quaternion-valued matrices. This gives new insights into the quaternion uncorrelating transform (QUT) and forms a basis for the proposed quaternion approximate uncorrelating transform (QAUT) which simultaneously diagonalises all four covariance matrices associated with improper quaternion signals. The effectiveness of the proposed uncorrelating transforms is validated by simulations on both synthetic and real-world quaternion-valued signals.Comment: 41 pages, single column, 10 figure