A Study of Relief Activities in Seven Nebraska Counties, 1927-1934

In the present study, an attempt was made to investigate the relief situation in Nebraska. The aim was (1) to determine how public relief funds were administered in the various counties of the state before the beginning of federal participation in relief, and what changes, if any, had come about after the federal relief agencies began to function, and also what volunteer relief agencies were available to supplement county relief in each case; (2) to determine, so far as possible, the actual amounts that were spent and for what purposes, and also the amounts of goods distributed by each county and by these various agencies during the years 1927 to 1934; and (3) to obtain information concerning the extent to which relief was extended to families actually engaged in farming. It also seemed desirable to learn something of the general attitude and personal opinions of the county officials and relief workers concerning the problem in general and concerning the relief clients themselves. Some attempt was therefore made to determine whether the relief clients were urban, small town, or farm people, what conditions placed them on relief, and how they were regarded by officials and others

Personality Development in Farm, Small-Town, and City Children

One purpose of the present research project was to contribute further toward an adequate knowledge of the relative merits of urban and rural environments. In this bulletin the three general home settings already mentioned, namely the farm in the open country, the small town (600 to 1,300 in population), and the city, are compared as to their favorableness in regard to the personality development of the children who grow up in them. The data for the comparisons are the average scores made by representative samples of young people from each environment on a set of tests and scales designed to measure certain aspects of character and personality. Certain home environmental factors and influences concerning which data were obtained, as well as other factors external to the home, are discussed in relation to some of the group differences in test performance which appeared

The Relation of Certain Factors in Farm Family Life to Personality Development in Adolescents

Although the family has been much written about, and studied from many points of view in the past, relatively little attention has been given by investigators to the problem of determining the factors which make for successful family life. The need for information of this sort is obvious, and in recent years a few studies have been made from this point of view. The present study was undertaken for the purpose of gathering further information about normal families and some of the home-environmental factors which are thought to contribute to, or hinder, the achievement of successful family life

The Relation of Certain Factors in Farm Family Life to Personality Development in Adolescents

Although the family has been much written about, and studied from many points of view in the past, relatively little attention has been given by investigators to the problem of determining the factors which make for successful family life. The need for information of this sort is obvious, and in recent years a few studies have been made from this point of view. The present study was undertaken for the purpose of gathering further information about normal families and some of the home-environmental factors which are thought to contribute to, or hinder, the achievement of successful family life

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies