Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies

Background: Diverse genetic backgrounds often lead to phenotypic heterogeneity in cardiomyopathies (CMPs). Previous genotype-phenotype studies have primarily focused on the analysis of a single phenotype, and the diagnostic and prognostic features of the CMP genotype across different phenotypic expressions remain poorly understood. Objectives: We sought to define differences in outcome prediction when stratifying patients based on phenotype at presentation compared with genotype in a large cohort of patients with CMPs and positive genetic testing. Methods: Dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy, left-dominant arrhythmogenic cardiomyopathy, and biventricular arrhythmogenic cardiomyopathy were examined in this study. A total of 281 patients (80% DCM) with pathogenic or likely pathogenic variants were included. The primary and secondary outcomes were: 1) all-cause mortality (D)/heart transplant (HT); 2) sudden cardiac death/major ventricular arrhythmias (SCD/MVA); and 3) heart failure-related death (DHF)/HT/left ventricular assist device implantation (LVAD). Results: Survival analysis revealed that SCD/MVA events occurred more frequently in patients without a DCM phenotype and in carriers of DSP, PKP2, LMNA, and FLNC variants. However, after adjustment for age and sex, genotype-based classification, but not phenotype-based classification, was predictive of SCD/MVA. LMNA showed the worst trends in terms of D/HT and DHF/HT/LVAD. Conclusions: Genotypes were associated with significant phenotypic heterogeneity in genetic cardiomyopathies. Nevertheless, in our study, genotypic-based classification showed higher precision in predicting the outcome of patients with CMP than phenotype-based classification. These findings add to our current understanding of inherited CMPs and contribute to the risk stratification of patients with positive genetic testing

The minimum crystal size needed for a complete diffraction data set

A formula for absolute scattering power is derived to include spot fading arising from radiation damage and the crystal volume needed to collect diffraction data to a given resolution is calculated

Centro de educación creativa [Español]

El programa de este año colaboro con la Escuela Centro de Educación Creativa, ubicado en el bosque nuboso de Monteverde. El cargo que tuvo el grupo de Futuros Sostenibles de parte del Centro de Educación Creativa ha sido realizar un plan maestro de los sistemas de agua de análisis de todo el sitio de sistemas de agua del campus y de la escuela, que trabajara para reducir, conservar y mantener el agua, el consumo y el uso. El plan maestro propone una serie de sistemas de tratamiento de aguas espacial reforzar la circulación existente, que complementa los programas educativos, y mitigar el consumo de agua al establecer una mayor identidad en el campus. This year’s program collaborated with the Cloud Forest School, located in the Monteverde Cloud Forest. Sustainable Future’s charge from CEC was to perform a campus wide water systems site analysis and campus water systems master plan, which will work toward reducing, conserving, and maintaining water consumption and usage. The master plan proposes a series of spatial water treatment systems reinforcing existing circulation, supplementing educational programs, and mitigating water consumption while establishing a greater campus identity.https://digitalcommons.usf.edu/tropical_ecology/1166/thumbnail.jp

Centro de educación creativa [Español]

El programa de este año colaboro con la Escuela Centro de Educación Creativa, ubicado en el bosque nuboso de Monteverde. El cargo que tuvo el grupo de Futuros Sostenibles de parte del Centro de Educación Creativa ha sido realizar un plan maestro de los sistemas de agua de análisis de todo el sitio de sistemas de agua del campus y de la escuela, que trabajara para reducir, conservar y mantener el agua, el consumo y el uso. El plan maestro propone una serie de sistemas de tratamiento de aguas espacial reforzar la circulación existente, que complementa los programas educativos, y mitigar el consumo de agua al establecer una mayor identidad en el campus. This year’s program collaborated with the Cloud Forest School, located in the Monteverde Cloud Forest. Sustainable Future’s charge from CEC was to perform a campus wide water systems site analysis and campus water systems master plan, which will work toward reducing, conserving, and maintaining water consumption and usage. The master plan proposes a series of spatial water treatment systems reinforcing existing circulation, supplementing educational programs, and mitigating water consumption while establishing a greater campus identity.https://digitalcommons.usf.edu/tropical_ecology/1166/thumbnail.jp

Centro de educación creativa [English]

La tarea del CEC es llevar a cabo un amplio análisis del sistema de agua en el sitio y un plan maestro del sistema de aguas. Centrarse en los sistemas de agua, consumo de agua y la gestión del agua en Costa Rica. The task of the CEC is to conduct a comprehensive analysis of the water system at the site and water system master plan. Focus on water systems, water consumption and water management in Costa Ricahttps://digitalcommons.usf.edu/sustainable_futures/1248/thumbnail.jp

Naphthalene-1-carbaldehyde oxime

The title compound, C11H9NO, crystallizes with two molecules, A and B, with similar conformations (r.m.s. overlay fit = 0.030 Å) in the asymmetric unit: the C—C=N...O torsion angles are −177.8 (3) and −179.1 (3)°. In the crystal, molecules are linked by alternating O—H...N (A → B) and O—H...O (B → A) hydrogen bonds to generate [100] chains. A weak C—H...O interaction is also observed