Transitional experiences of post-16 sports education: Jack's story

This paper explores the layered transitional experiences of a semi-professional athlete named Jack (a pseudonym) between the fields of professional sport and further and higher education. Our analysis is framed by the quadripartite framework of structuration and focuses on Jack's 'in-situ' practices at his college and university in order to illustrate how these can operate to reproduce, transform, and challenge the habitual discourses and rituals that circulate within these institutions by generating forms of corporeal empowerment for young athletes who have valued conjunctural knowledge. The findings highlight the fragility of the transition process and raise questions regarding how the experiences of young people are shaped by the relationships between employment and post-16 education. Jack's experiences have implications for both policy and practice within further education and higher education. © 2012 © 2012 Taylor & Francis

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved

South African Adolescents' Explanations for Juvenile Delinquency

Research in other parts of the world suggests that adolescents invoke a multiplicity of causes to explain juvenile offending. The extent to which the different explanations are endorsed appears partly to be a function of cultural and demographic characteristics. The aim of this study was to investigate South African adolescents' explanations for delinquency and to examine cultural differences in these explanations. A total of 554 secondary school pupils from two Eastern Cape high schools rated 39 explanations for juvenile offending on a Likert scale. Principal component analysis and a varimax rotation of the responses identified seven factors - Home Environment, Antisocial Tendency, Influencability, Social Control, Emotional Adjustment, Deprivation and Social Alienation. The results showed that there were large differences between the Black and White learners in terms of the perceived importance of a number of the explanatory causes. </jats:p

Racial attitudes among South African young adults: A four-year follow-up study

The many social changes that have occurred in South Africa since the first democratic elections in 1994 warrant that careful scrutiny be given to the racial attitudes of South Africa's young adults. Their degree of acceptance of the doctrine of deracialisation and reconciliation represents a hope or a warning about the possibility of a stable future. A follow-up study was thus carried out in order to update data collected in 1995, with the hypothesis that, over time, greater acceptance of other racial groups would be reported. In this follow-up study, the authors examined differences among a new sample of 122 Xhosa-speaking Black, 73 so-called coloured, and 234 English-speaking White young adults. Data were collected using a questionnaire that assessed aspects of these groups' perceptions of themselves (identities) and their attitudes toward other racial groups (their prejudice). Statistical significance was found between groups and over time across measures.Articl

Ethnic identity and racial attitudes in a minority group of mixed racial origin

Limited information exists on the racial attitudes and ethnic identities of groups of mixed racial origin. The present research tested the hypotheses that the construct of ethnic identity is valid among such groups and that ethnic identity is related to out-group prejudice, as predicted by social identity theory. The Multigroup Ethnic Identity Measure, the Anti-White Scale, and the Subtle Racism Scale were administered to 70 South Africans of mixed racial descent, the so-called Coloureds. A factor analysis supported the structural validity of the 12-item measure of ethnic identity with this sample, but correlations between scales did not support the prediction that group identity would be positively associated with out-group prejudice. Group identity was positively related .27 to positive attitudes toward Whites consistent with the tenets of social dominance theory.Articl