Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube

Facial branchiomotor neurons (FBMNs) in zebrafish and mouse embryonic hindbrain undergo a characteristic tangential migration from rhombomere (r) 4, where they are born, to r6/7. Cohesion among neuroepithelial cells (NCs) has been suggested to function in FBMN migration by inhibiting FBMNs positioned in the basal neuroepithelium such that they move apically between NCs towards the midline of the neuroepithelium instead of tangentially along the basal side of the neuroepithelium towards r6/7. However, direct experimental evaluation of this hypothesis is still lacking. Here, we have used a combination of biophysical cell adhesion measurements and high-resolution time-lapse microscopy to determine the role of NC cohesion in FBMN migration. We show that reducing NC cohesion by interfering with Cadherin 2 (Cdh2) activity results in FBMNs positioned at the basal side of the neuroepithelium moving apically towards the neural tube midline instead of tangentially towards r6/7. In embryos with strongly reduced NC cohesion, ectopic apical FBMN movement frequently results in fusion of the bilateral FBMN clusters over the apical midline of the neural tube. By contrast, reducing cohesion among FBMNs by interfering with Contactin 2 (Cntn2) expression in these cells has little effect on apical FBMN movement, but reduces the fusion of the bilateral FBMN clusters in embryos with strongly diminished NC cohesion. These data provide direct experimental evidence that NC cohesion functions in tangential FBMN migration by restricting their apical movement

A diagrammatic treatment of neutrino oscillations

We present a covariant wave-packet approach to neutrino flavor transitions in vacuum. The approach is based on the technique of macroscopic Feynman diagrams describing the lepton number violating processes of production and absorption of virtual massive neutrinos at the macroscopically separated space-time regions ("source" and "detector"). Accordingly, the flavor transitions are a result of interference of the diagrams with neutrinos of different masses in the intermediate states. The statistically averaged probability of the process is representable as a multidimensional integral of the product of the factors which describe the differential flux density of massless neutrinos from the source, differential cross section of the neutrino interaction with the detector and a dimensionless factor responsible for the flavor transition. The conditions are analyzed under which the last factor can be treated as the flavor transition probability in the usual quantum-mechanical sense.Comment: 27 pages,7 figures, iopart class. Includes minor corrections made in proofs. References update

A potential test of the CP properties and Majorana nature of neutrinos

The scattering of solar neutrinos on electrons may reveal their CP properties, which are particularly sensitive to their Majorana nature. The cross section is sensitive to the neutrino dipole moments through an interference of electro-magnetic and weak amplitudes. We show how future solar neutrino experiments with good angular resolution and low energy threshold, such as Hellaz, can be sensitive to the resulting azimuthal asymmetries in event number, and could therefore provide valuable information on the CP properties and the nature of the neutrinos, provided the solar magnetic field direction is fixed.Comment: 14 pages, 1 figure, eq. (19) corrected. Version to be publishe

Effects of neutrino oscillations and neutrino magnetic moments on elastic neutrino-electron scattering

We consider elastic antineutrino-electron scattering taking into account possible effects of neutrino masses and mixing and of neutrino magnetic moments and electric dipole moments. Having in mind antineutrinos produced in a nuclear reactor we compute, in particular, the weak-electromagnetic interference terms which are linear in the magnetic (electric dipole) moments and also in the neutrino masses. We show that these terms are, however, suppressed compared to the pure weak and electromagnetic cross section. We also comment upon the possibility of using the electromagnetic cross section to investigate neutrino oscillations.Comment: 12 pages, REVTEX file, no figures, submitted to Phys.Rev.

Awakening the sleeping giant of urban green in times of crisis—coverage, co-creation and practical guidelines for optimizing biodiversity-friendly and health-promoting residential greenery

As multiple crises deepen existing inequalities in urban societies within and between neighborhoods, strategically integrating nature-based solutions into the living environment can help reduce negative impacts and improve public health, social cohesion, and well-being. Compared to public green such as parks, semi-public residential greenery is rarely studied, is regularly overlooked by planners, and often receives step-motherly treatment from architects and housing companies. We approximated the area of residential greenery of modernist multi-story apartment complexes in Berlin, Germany. We surveyed residents’ suggestions for improving their living environments in vulnerable neighborhoods, report on co-creation experiences, and provide a practical guideline for optimizing health-promoting residential green spaces. The semi-public open space on the doorstep of two-thirds of Berlin’s population is highly fragmented and, in total, has a similar area as the public green spaces and a great potential for qualitative development. Just as the suitability of different nature-based solutions to be integrated into the residential greenery depends on building types, resident demands differ between neighborhoods. Residents called for more involvement in design, implementation, and maintenance, frequently proposing that biodiversity-friendly measures be included. As there is no universal solution even for neighborhoods sharing similar structural and socioeconomic parameters, we propose, and have tested, an optimization loop for health-promoting residential greening that involves exploring residents’ needs and co-creating local solutions for urban regeneration processes that can be initiated by different actors using bottom-up and/or top-down approaches in order to unlock this potential for healthy, livable and biodiversity friendly cities.Peer Reviewe

Awakening the sleeping giant of urban green in times of crisis—coverage, co-creation and practical guidelines for optimizing biodiversity-friendly and health-promoting residential greenery

As multiple crises deepen existing inequalities in urban societies within and between neighborhoods, strategically integrating nature-based solutions into the living environment can help reduce negative impacts and improve public health, social cohesion, and well-being. Compared to public green such as parks, semi-public residential greenery is rarely studied, is regularly overlooked by planners, and often receives step-motherly treatment from architects and housing companies. We approximated the area of residential greenery of modernist multi-story apartment complexes in Berlin, Germany. We surveyed residents’ suggestions for improving their living environments in vulnerable neighborhoods, report on co-creation experiences, and provide a practical guideline for optimizing health-promoting residential green spaces. The semi-public open space on the doorstep of two-thirds of Berlin’s population is highly fragmented and, in total, has a similar area as the public green spaces and a great potential for qualitative development. Just as the suitability of different nature-based solutions to be integrated into the residential greenery depends on building types, resident demands differ between neighborhoods. Residents called for more involvement in design, implementation, and maintenance, frequently proposing that biodiversity-friendly measures be included. As there is no universal solution even for neighborhoods sharing similar structural and socioeconomic parameters, we propose, and have tested, an optimization loop for health-promoting residential greening that involves exploring residents’ needs and co-creating local solutions for urban regeneration processes that can be initiated by different actors using bottom-up and/or top-down approaches in order to unlock this potential for healthy, livable and biodiversity friendly cities

Data scientists

What is a data scientist? How can you become one? How can you form a team of data scientists that fits your organization? In this chapter, we trace the skillset of a successful data scientist and define the necessary competencies. We give a disambiguation to other historically or contemporary definitions of the term, and show how a career as a data scientist might get started. Finally we will answer the above mentioned third question, i.e. how to build analytics teams within a data-driven organization