Mille Pompons! Fantômette, the Famous, Unknown, Schoolgirl Superhero of France

One significant character in French and Francophone literature aimed at young girls is completely absent from English language culture.  The books and other media about crime fighting schoolgirl Françoise Dupont / Fantômette have not been translated into English and are very sparsely represented in American and British libraries.  She is ubiquitous enough in Francophone culture to be referred to without any explanation (much as English publications would reference a detective named Nancy or Hermione the witch).  Who is this heroine and why have we never heard of her?   DOI: 10.1353/jeu.2020.001

Discovery of Inhibitors of Leishmania β-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library

Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve polymer termed mannogen. Mannogen is a soluble homopolymer of β-1,2-linked mannose residues that accumulates in the major pathogenic stages in the sandfly vector and mammalian host. While several steps in mannogen biosynthesis have been defined, none of the enzymes have been isolated or characterized. We report the development of a simple assay for the GDP-mannose–dependent β-1,2-mannosyltransferases involved in mannogen synthesis. This assay utilizes octyl α-d-mannopyranoside to prime the formation of short mannogen oligomers up to 5 mannose residues. This assay was used to screen a focussed library of 44 GMP-triazole adducts for inhibitors. Several compounds provided effective inhibition of mannogen β-1,2-mannosyltransferases in a cell-free membrane preparation. This assay and inhibitor compounds will be useful for dissecting the role of different mannosyltransferases in regulating de novo biosynthesis and elongation reactions in mannogen metabolism

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Invisible Rendezvous (Book Review)

published or submitted for publicatio

Librarian as fair witness : a comparison of Heinlein's futuristic occupation and today's evolving information professional

There has been a continuing discussion in library literature on the library as place and on the image of librarians in popular media, but there is little information on the librarian as person. The discussion on librarianship as a profession tends to focus on technology and not so much the people, other than the people skills needed in reference or teaching skills needed for instruction. The worth of the individual librarian tends to get lost in the shuffle. Before we disappear into the machine, it is useful to look at other future scenarios and similar occupations, either reality based or fiction. In this particular case, it is interesting to compare librarians to those in an occupation created by a renowned science fiction author.Published versio

Librarians’ Use of Images on LibGuides and Other Social Media Platforms

This study compared the use of librarians’ profile images across Web platforms designed for librarian-patron communication. The primary focus was LibGuides profiles at a peer group of ARL institutions. Librarians are currently using a variety of options, including professional head shots, casual head shots, other photos, alternate images, avatars, and no image. Where possible, results were also analyzed by gender. For a smaller selection of libraries, LibGuides photos were compared with Facebook photos to see if different images were used for a professional versus a personal social media setting. This research was done in December 2010 and duplicated in May 2012 to track changes over time. The later study also reviews profile images for the smaller selection of libraries in LinkedIn and ALA Connect. The findings provide a baseline for further comparative research, could also inform individual librarians’ image choices based on patterns among their peers, and gives the profession a starting point for discussions about the types of images librarians use.Peer reviewedThis is an Author's Accepted Manuscript of an Article published in Journal of Web Librarianship (2013), available online at: http://www.tandfonline.com/10.1080/19322909.2013.812473