"Selbstscreen-Prodrom" - ein Selbstbeurteilungsinstrument zur Früherkennung von psychischen Erkrankungen und Psychosen

OBJECTIVE: In the past years, the significance of early detection of psychoses has been increasingly recognized. Screening for the onset of disorders should focus on individuals seeking treatment in an outpatient setting and should preferably operate stepwise. Within a prospective study for the early detection of psychoses (FePsy = Früh Erkennung von PSYchosen) the self-rating instrument "Self-screen Prodrome" was developed to differentiate between healthy individuals, individuals with psychosis or an at-risk mental state for psychosis and patients with other ICD-10 diagnoses. METHOD: The "Self-screen Prodrome" was developed by taking established risk factors and early signs of disease into account. In particular, prodromes and pre-psychotic symptoms were captured. A total score and a subscale were analyzed with regard to validity and reliability. RESULTS: The total score "Self-screen Prodrome" distinguished between outpatients with a mental disorder and healthy individuals (Cut-off < or = 6; sensitivity: 85 % specificity: 91 %). Additionally the subscale distinguished between psychosis-(risk)-individuals and outpatients with other ICD-10 psychiatric diagnoses (Cut-off < or = 2; sensitivity: 85 % specificity: 39 %). CONCLUSION: The "Self-screen Prodrome" is a useful instrument that a) separates mentally ill patients from healthy individuals and b) filters individuals with a risk of developing psychoses from patients with other ICD-10 diagnoses for further screening. The next step in the early detection of psychoses for identified individuals should be a detailed psychiatric exploration by experts

Radioisotopes and coastal research in the Great Barrier Reef

Radioisotopes are efficient tracers of coastal processes on various spatial and temporal scales. The isotopes of radon and radium are particularly useful tools to understand hydrological land-ocean interaction because (a) activities of these isotopes are elevated in groundwater by two to three orders of magnitude in comparison with seawater, and (b) these isotopes have half-lives similar to the time scales of coastal hydrological processes such as river and groundwater discharge to the ocean, as well as coastal ocean mixing (or residence) time. The application of these isotopes to studies of land-ocean interaction in the central Great Barrier Reef region (Townsville to Cooktown) is illustrated in three recent studies: (1) coastal mapping of radon on a regional scale improves the understanding of the spatial variability of river and groundwater fluxes to the Great Barrier Reef lagoon; (2) quantification of tidal water exchange between mangrove forests and creeks demonstrates the significant contributions this process makes to water flux and associated geochemical fluxes along tropical coastlines; (3) estimates of coastal water residence time contribute to the understanding of the fate of land-derived solutes in the Great Barrier Reef Lagoon. Concurrent mapping of 222Rn (half-life 3.8 days) and salinity allows an efficient qualitative assessment of land–ocean interaction on various spatial and temporal scales. From shore-parallel transects along the Central Great Barrier Reef coastline with a surface-towed and continuously recording multi-detector system, numerous locations of elevated radon activities can be identified as terrestrially-derived submarine groundwater discharge, riverine sources, and the recirculation of seawater through crustacean burrows in mangrove forests. Variations in the inverse relationship of 222Rn and salinity in different tropical wet seasons reveal ‘timing’ aspects of large-scale freshwater input during the tropical wet season into the lagoon. Subsequently, 222Rn was used together with radium isotopes to quantify the tidal water exchange between a mangrove forest on Hinchinbrook Island and the ocean. Significant export of these radio-nuclides from the forest into a tidal creek indicates continuous tidally-driven circulation through animal burrows in the forest. The forest floor is efficiently flushed, with water flux of about 30 L m-2 day-1 of forest floor, which is equivalent to about 10% of the total burrow volume in the forest per tidal cycle. This work illustrates the physical process which supports export of organic and inorganic matter from mangrove forests to the coastal zone. Importantly, annual average circulation fluxes through mangrove forest floors are of the same order as annual river discharge in the central GBR. Finally, an improved understanding of the fate of land-derived waters is of great importance to current discussions about water quality management in the Great Barrier Reef. The mixing of coastal waters is an important parameter influencing the health of these ecosystems. Time constants associated with the decay of four naturally-occurring isotopes of radium span large time scales; 224Ra, 223Ra, 228Ra and 226Ra have half-lives of 4 days, 11 days, 6 years and 1620 years respectively. The radium quartet has been used to determine time scales of mixing of near-shore water and deep ocean water. This study demonstrates that central GBR water within 20 km of the coast is flushed with outer lagoon water on a timescale of 18–45 days, with the flushing time increasing northward. This difference likely reflects the different reef matrix density in the two zones, affecting exchange with offshore Coral Sea water

A New Coupled CFD/Neutron Kinetics System for High Fidelity Simulations of LWR Core Phenomena: Proof of Concept

The Institute for Neutron Physics and Reactor Technology (INR) at the Karlsruhe Institute of Technology (KIT) is investigating the application of the meso- and microscale analysis for the prediction of local safety parameters for light water reactors (LWR). By applying codes like CFD (computational fluid dynamics) and SP3 (simplified transport) reactor dynamics it is possible to describe the underlying phenomena in a more accurate manner than by the nodal/coarse 1D thermal hydraulic coupled codes. By coupling the transport (SP3) based neutron kinetics (NK) code DYN3D with NEPTUNE-CFD, within a parallel MPI-environment, the NHESDYN platform is created. The newly developed system will allow high fidelity simulations of LWR fuel assemblies and cores. In NHESDYN, a heat conduction solver, SYRTHES, is coupled to NEPTUNE-CFD. The driver module of NHESDYN controls the sequence of execution of the solvers as well as the communication between the solvers based on MPI. In this paper, the main features of NHESDYN are discussed and the proof of the concept is done by solving a single pin problem. The prediction capability of NHESDYN is demonstrated by a code-to-code comparison with the DYNSUB code. Finally, the future developments and validation efforts are highlighted

Design Requirements for AI-based Services Enriching Legacy Information Systems in Enterprises: A Managerial Perspective

Information systems (IS) have been introduced in enterprises for decades to generate business value. Historically systems that are deeply integrated into business processes and not replaced remain vital assets, and thus become legacy IS (LISs). To secure the future success, enterprises invest in innovative technologies such as artificial intelligence-based services (AIBSs), enriching LISs and assisting employees in the execution of work-related tasks. This study develops design requirements from a managerial perspective by following a mixed-method approach. First, we conducted ten interviews to formulate requirements to design AIBSs. Second, we evaluated their business value using an online survey (N = 101). The results indicate that executives consider design requirements as relevant that create strategic advancements in the short term. With the help of our findings, researchers can better understand where further in-depth studies are needed to refine the requirements. Practitioners can learn how AIBSs generate business value when enriching LISs

Towards Successful Collaboration: Design Guidelines for AI-based Services enriching Information Systems in Organisations

Information systems (IS) are widely used in organisations to improve business performance. The steady progression in improving technologies like artificial intelligence (AI) and the need of securing future success of organisations lead to new requirements for IS. This research in progress firstly introduces the term AI-based services (AIBS) describing AI as a component enriching IS aiming at collaborating with employees and assisting in the execution of work-related tasks. The study derives requirements from ten expert interviews to successful design AIBS following Design Science Research (DSR). For a successful deployment of AIBS in organisations the D&M IS Success Model will be considered to validated requirements within three major dimensions of quality: Information Quality, System Quality, and Service Quality. Amongst others, preliminary findings propose that AIBS must be preferably authentic. Further discussion and research on AIBS is forced, thus, providing first insights on the deployment of AIBS in organisations