Dynamics of railway freight vehicles

This paper summarises the historical development of railway freight vehicles and how vehicle designers have tackled the difficult challenges of producing running gear which can accommodate the very high tare to laden mass of typical freight wagons whilst maintaining stable running at the maximum required speed and good curving performance. The most common current freight bogies are described in detail and recent improvements in techniques used to simulate the dynamic behaviour of railway vehicles are summarised and examples of how these have been used to improve freight vehicle dynamic behaviour are included. A number of recent developments and innovative components and sub systems are outlined and finally two new developments are presented in more detail: the LEILA bogie and the SUSTRAIL bogie

Supersymmetrization of the Radiation Damping

We construct a supersymmetrized version of the model to the radiation damping \cite{03} introduced by the present authors \cite{ACWF}. We dicuss its symmetries and the corresponding conserved Noether charges. It is shown this supersymmetric version provides a supersymmetric generalization of the Galilei algebra obtained in \cite{ACWF}. We have shown that the supersymmetric action can be splited into dynamically independent external and internal sectors.Comment: 9 page

Jacobson generators, Fock representations and statistics of sl(n+1)

The properties of A-statistics, related to the class of simple Lie algebras sl(n+1) (Palev, T.D.: Preprint JINR E17-10550 (1977); hep-th/9705032), are further investigated. The description of each sl(n+1) is carried out via generators and their relations, first introduced by Jacobson. The related Fock spaces W_p (p=1,2,...) are finite-dimensional irreducible sl(n+1)-modules. The Pauli principle of the underlying statistics is formulated. In addition the paper contains the following new results: (a) The A-statistics are interpreted as exclusion statistics; (b) Within each W_p operators B(p)_1^\pm, ..., B(p)_n^\pm, proportional to the Jacobson generators, are introduced. It is proved that in an appropriate topology the limit of B(p)_i^\pm for p going to infinity is equal to B_i^\pm, where B_i^\pm are Bose creation and annihilation operators; (c) It is shown that the local statistics of the degenerated hard-core Bose models and of the related Heisenberg spin models is p=1 A-statistics.Comment: LaTeX-file, 33 page

Symmetries of field theories on the non-commutative plane

New developments on the symmetries of non-relativistic field theoretical models on the non commutative plane are reviewed. It is shown in particular that Galilean invariance strongly restricts the admissible interactions. Moreover, if a scalar field is coupled to a Chern - Simons gauge field, a geometrical phase emerges for vortex - like solutions, transformed by Galilei boosts.Comment: Reference corrected. Talk presented by LM at the International Workshop Nonlinear Physics: Theory and Experiment III. Gallipoli, (Lecce, Italy) 2004. To appear in Theor. Math. Phys. Latex 9 page

Genetic and epigenetic characterization of posterior pituitary tumors

Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be challenging to distinguish and have been proposed to represent a histological spectrum of a single entity. We performed targeted next-generation sequencing, DNA methylation profiling, and copy number analysis on 47 tumors (14 PITUI; 12 GCT; 21 SCO) to investigate molecular features and explore possibilities of clinically meaningful tumor subclassification. We detected two main epigenomic subgroups by unsupervised clustering of DNA methylation data, though the overall methylation differences were subtle. The largest group (n = 23) contained most PITUIs and a subset of SCOs and was enriched for pathogenic mutations within genes in the MAPK/PI3K pathways (12/17 [71%] of sequenced tumors: FGFR1 (3), HRAS (3), BRAF (2), NF1 (2), CBL (1), MAP2K2 (1), PTEN (1)) and two with accompanying TERT promoter mutation. The second group (n = 16) contained most GCTs and a subset of SCOs, all of which mostly lacked identifiable genetic drivers. Outcome analysis demonstrated that the presence of chromosomal imbalances was significantly associated with reduced progression-free survival especially within the combined PITUI and SCO group (p = 0.031). In summary, we observed only subtle DNA methylation differences between posterior pituitary tumors, indicating that these tumors may be best classified as subtypes of a single entity. Nevertheless, our data indicate differences in mutation patterns and clinical outcome. For a clinically meaningful subclassification, we propose a combined histo-molecular approach into three subtypes: one subtype is defined by granular cell histology, scarcity of identifiable oncogenic mutations, and favorable outcome. The other two subtypes have either SCO or PITUI histology but are segregated by chromosomal copy number profile into a favorable group (no copy number changes) and a less favorable group (copy number imbalances present). Both of the latter groups have recurrent MAPK/PI3K genetic alterations that represent potential therapeutic targets

Diffuse Glioneuronal tumour with Oligodendroglioma‐like features and Nuclear Clusters (DGONC) – a molecularly‐defined glioneuronal CNS tumour class displaying recurrent monosomy 14

Aims: DNA methylation-based central nervous system (CNS) tumour classification has identified numerous molecularly distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that were previously thought to represent homogeneous diseases. Our study aimed at characterizing a novel, molecularly defined variant of glioneuronal CNS tumour. Patients and methods: DNA methylation profiling was performed using the Infinium MethylationEPIC or 450 k BeadChip arrays (Illumina) and analysed using the 'conumee' package in R computing environment. Additional gene panel sequencing was also performed. Tumour samples were collected at the German Cancer Research Centre (DKFZ) and provided by multinational collaborators. Histological sections were also collected and independently reviewed. Results: Genome-wide DNA methylation data from >25 000 CNS tumours were screened for clusters separated from established DNA methylation classes, revealing a novel group comprising 31 tumours, mainly found in paediatric patients. This DNA methylation-defined variant of low-grade CNS tumours with glioneuronal differentiation displays recurrent monosomy 14, nuclear clusters within a morphology that is otherwise reminiscent of oligodendroglioma and other established entities with clear cell histology, and a lack of genetic alterations commonly observed in other (paediatric) glioneuronal entities. Conclusions: DNA methylation-based tumour classification is an objective method of assessing tumour origins, which may aid in diagnosis, especially for atypical cases. With increasing sample size, methylation analysis allows for the identification of rare, putative new tumour entities, which are currently not recognized by the WHO classification. Our study revealed the existence of a DNA methylation-defined class of low-grade glioneuronal tumours with recurrent monosomy 14, oligodendroglioma-like features and nuclear clusters