Setting firmer constraints on the evolution of the most massive, central galaxies from their local abundances and ages

There is still much debate surrounding how the most massive, central galaxies in the local universe have assembled their stellar mass, especially the relative roles of in-situ growth versus later accretion via mergers. In this paper, we set firmer constraints on the evolutionary pathways of the most massive central galaxies by making use of empirical estimates on their abundances and stellar ages. The most recent abundance matching and direct measurements strongly favour that a substantial fraction of massive galaxies with Mstar>3x10^11 Msun reside at the centre of clusters with mass Mhalo>3x10^13 Msun. Spectral analysis supports ages >10 Gyrs, corresponding to a formation redshift z_form >2. We combine these two pieces of observationally-based evidence with the mass accretion history of their host dark matter haloes. We find that in these massive haloes, the stellar mass locked up in the central galaxy is comparable to, if not greater than, the total baryonic mass at z_form. These findings indicate that either only a relatively minor fraction of their present-day stellar mass was formed in-situ at z_form, or that these massive, central galaxies form in the extreme scenario where almost all of the baryons in the progenitor halo are converted into stars. Interestingly, the latter scenario would not allow for any substantial size growth since the galaxy's formation epoch either via mergers or expansion. We show our results hold irrespective of systematic uncertainties in stellar mass, abundances, galaxy merger rates, stellar initial mass function, star formation rate and dark matter accretion histories.Comment: 11 pages, 8 figures, MNRAS, accepte

The influence of a high intensity physical activity intervention on a selection of health related outcomes: an ecological approach

<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease (CVD) is the main cause of mortality throughout the world. With accumulating evidence suggesting that CVD has its origins in childhood, it is unsurprising that research into obesity prevalence within school aged youth is burgeoning.</p> <p>Within this study our primary objective will be to examine whether high intensity interval training (HIT) improves the CVD risk profile of secondary school aged adolescents. Our secondary objective will be to identify the prevalence of CVD risk factors and examine factors associated with these in adolescents aged 15 - 18 years.</p> <p>Method/Design</p> <p>A South Lanarkshire school of low socioeconomic status (SES) was selected to participate in the study intervention. Participants from secondary 5 (15 - 17 years) and 6 (16 - 18 years) will be recruited for this study. Participants from secondary 6 will be randomly assigned to Group A (HIT) or Group B (moderate-vigorous) and will perform each protocol three times weekly. The secondary 5 participants will act as the control group. Data collection will take place during the Physical Education (PE) lessons and on school premises and will include: anthropometrical variables (height, weight, waist and hip circumferences, skinfold thickness at two sites), physiological responses (blood pressure, aerobic fitness, heart rate (HR) response, vertical jump performance, 10-metre (m) sprint, 50-m sprint and 505-agility test), diet (self-reported seven-day food diary), physical activity (Physical Activity Questionnaire for Adolescents (PAQ-A)) and blood tests (fasting glucose, insulin, total cholesterol (TC), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), fibrinogen (Fg), interleukin-6 (IL-6), adiponectin (high molecular weight), triglyceride and plasminogen activator inhibitor-1 (PAI-1). An environmental audit of the secondary school and the health related quality of life (HRQOL) of the participants will also be measured. Finally, all exercise sessions will be video recorded and rate of perceived exertion (RPE) and mood states will also be taken after each exercise session.</p> <p>Discussion</p> <p>Our study may be able to demonstrate a time efficient means of reducing CVD risk factors in adolescents.</p> <p>Trial Registration</p> <p>NCT01027156</p

Revisiting the bulge-halo conspiracy I: Dependence on galaxy properties and halo mass

We carry out a systematic investigation of the total mass density profile of massive (Mstar>2e11 Msun) early-type galaxies and its dependence on galactic properties and host halo mass with the aid of a variety of lensing/dynamical data and large mock galaxy catalogs. The latter are produced via semi-empirical models that, by design, are based on just a few basic input assumptions. Galaxies, with measured stellar masses, effective radii and S\'{e}rsic indices, are assigned, via abundance matching relations, host dark matter halos characterized by a typical LCDM profile. Our main results are as follows: (i) In line with observational evidence, our semi-empirical models naturally predict that the total, mass-weighted density slope at the effective radius gamma' is not universal, steepening for more compact and/or massive galaxies, but flattening with increasing host halo mass. (ii) Models characterized by a Salpeter or variable initial mass function and uncontracted dark matter profiles are in good agreement with the data, while a Chabrier initial mass function and/or adiabatic contractions/expansions of the dark matter halos are highly disfavored. (iii) Currently available data on the mass density profiles of very massive galaxies (Mstar>1e12 Msun), with Mhalo>3e14 Msun, favor instead models with a stellar profile flatter than a S\'{e}rsic one in the very inner regions (r<3-5 kpc), and a cored NFW or Einasto dark matter profile with median halo concentration a factor of ~2 or <1.3, respectively, higher than those typically predicted by N-body numerical simulations.Comment: 23 pages, 10 figures, 3 Appendices (with an extra 7 figures). ApJ, accepted. Main results in Figures 3, 5, 6,

Interrogating the language of integration: the case of internationally recruited nurses

AIMS: This paper suggested the need to interrogate the notion of 'integration' to facilitate the retention of migrant nurses. BACKGROUND: The growth in internationally recruited nurses in the UK's health system has led to a raft of policies that aim to ensure that such nurses are well 'integrated' into their 'new environment'. It is assumed that integration will improve the quality of internationally recruited nurses' experience in the UK, improve their retention rates and thus improve the quality of health delivery within the UK. However, most of the steps through which integration is sought tend to move between some version of assimilation and 'respect for difference'. CONTRIBUTIONS: This paper aimed to add to existing literature on the integration of internationally recruited nurses in the UK by suggesting three steps towards rethinking 'integration policies'. It suggests the need to recognize migration as only one of the differentiating factors within the nursing sector, to ensure that integration does actually become a two-way process and to be cognizant of the multiple shapes that racism can take. The first two steps will prevent a slip between integration and assimilation while the last will help rethink any anti-racist training that may form part of integration policies. CONCLUSIONS: There are many factors influencing the experiences of internationally recruited nurses and not all of them can be addressed within current integration policies. RELEVANCE TO CLINICAL PRACTICE: Rethinking integration can help improve the experience of internationally recruited nurses

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11

Variants in NDUFB11, which encodes a structural component of complex I of the mitochondrial respiratory chain (MRC), were recently independently reported to cause histiocytoid cardiomyopathy (histiocytoid CM) and microphthalmia with linear skin defects syndrome (MLS syndrome). Here we report an additional case of histiocytoid CM, which carries a de novo nonsense variant in NDUFB11 (ENST00000276062.8: c.262C > T; p.[Arg88*]) identified using whole-exome sequencing (WES) of a family trio. An identical variant has been previously reported in association with MLS syndrome. The case we describe here lacked the diagnostic features of MLS syndrome, but a detailed clinical comparison of the two cases revealed significant phenotypic overlap. Heterozygous variants in HCCS (which encodes an important mitochondrially targeted protein) and COX7B, which, like NDUFB11, encodes a protein of the MRC, have also previously been identified in MLS syndrome including a case with features of both MLS syndrome and histiocytoid CM. However, a systematic review of WES data from previously published histiocytoid CM cases, alongside four additional cases presented here for the first time, did not identify any variants in these genes. We conclude that NDUFB11 variants play a role in the pathogenesis of both histiocytoid CM and MLS and that these disorders are allelic (genetically related)

Avoiding Progenitor Bias: The Structural and Mass Evolution of Brightest Group and Cluster Galaxies in Hierarchical Models since z≾1

The mass and structural evolution of massive galaxies is one of the hottest topics in galaxy formation. This is because it may reveal invaluable insights into the still debated evolutionary processes governing the growth and assembly of spheroids. However, direct comparison between models and observations is usually prevented by the so-called progenitor bias, i.e., new galaxies entering the observational selection at later epochs, thus eluding a precise study of how pre-existing galaxies actually evolve in size. To limit this effect, we here gather data on high-redshift brightest group and cluster galaxies, evolve their (mean) host halo masses down to z = 0 along their main progenitors, and assign as their "descendants" local Sloan Digital Sky Survey central galaxies matched in host halo mass. At face value, the comparison between high redshift and local data suggests a noticeable increase in stellar mass of a factor of ≳ 2 since z ~ 1, and of ≳ 2.5 in mean effective radius. We then compare the inferred stellar mass and size growth with those predicted by hierarchical models for central galaxies, selected at high redshifts to closely match the halo and stellar mass bins as in the data. Only hierarchical models characterized by very limited satellite stellar stripping and parabolic orbits are capable of broadly reproducing the stellar mass and size increase of a factor of ~2-4 observed in cluster galaxies since z ~ 1. The predicted, average (major) merger rate since z ~ 1 is in good agreement with the latest observational estimates

On the intermediate-redshift central stellar mass-halo mass relation, and implications for the evolution of the most massive galaxies since Z~1

The stellar mass-halo mass relation is a key constraint in all semi-analytic, numerical, and semi-empirical models of galaxy formation and evolution. However, its exact shape and redshift dependence remain under debate. Several recent works support a relation in the local universe steeper than previously thought. Based on comparisons with a variety of data on massive central galaxies, we show that this steepening holds up to z ~ 1 for stellar masses M star gsim 2 × 1011 M ?. Specifically, we find significant evidence for a high-mass end slope of ? gsim 0.35-0.70 instead of the usual ? lesssim 0.20-0.30 reported by a number of previous results. When including the independent constraints from the recent Baryon Oscillation Spectroscopic Survey clustering measurements, the data, independent of any systematic errors in stellar masses, tend to favor a model with a very small scatter (lesssim 0.15 dex) in stellar mass at fixed halo mass, in the redshift range z &lt; 0.8 and for M star &gt; 3 × 1011 M ?, suggesting a close connection between massive galaxies and host halos even at relatively recent epochs. We discuss the implications of our results with respect to the evolution of the most massive galaxies since z ~ 1

Estimating relative risk of within-lake aquatic plant invasion using combined measures of recreational boater movement and habitat suitability

Effective monitoring, prevention and impact mitigation of nonindigenous aquatic species relies upon the ability to predict dispersal pathways and receiving habitats with the greatest risk of establishment. To examine mechanisms affecting species establishment within a large lake, we combined observations of recreational boater movements with empirical measurements of habitat suitability represented by nearshore wave energy to assess the relative risk of Eurasian watermilfoil (Myriophyllum spicatum) establishment. The model was evaluated using information from a 17 year (1995–2012) sequence of M. spicatum presence and absence monitoring. M. spicatum presence was not specifically correlated with recreational boater movements; however its establishment appears to be limited by wave action in Lake Tahoe. Of the sites in the “High” establishment risk category (n = 37), 54% had current or historical infestations, which included 8 of the 10 sites with the highest relative risk. Of the 11 sites in the “Medium” establishment risk category, 5 had current or historical M. spicatum populations. Most (76%) of the sites in the “Low” establishment risk category were observed in locations with higher wave action. Four sites that received zero boater visits from infested locations were occupied by M. spicatum. This suggests that the boater survey either represents incomplete coverage of boater movement, or other processes, such as the movement of propagules by surface currents or introductions from external sources are important to the establishment of this species. This study showed the combination of habitat specific and dispersal data in a relative risk framework can potentially reduce uncertainty in estimates of invasion risk

New Role, New Country: introducing US physician assistants to Scotland

This paper draws from research commissioned by the Scottish Executive Health Department (SEHD). It provides a case study in the introduction of a new health care worker role into an already well established and "mature" workforce configuration It assesses the role of US style physician assistants (PAs), as a precursor to planned "piloting" of the PA role within the National Health Service (NHS) in Scotland