Generation of the Ares I-X Flight Test Vehicle Aerodynamic Data Book and Comparison To Flight

A 3.5-year effort to characterize the aerodynamic behavior of the Ares I-X Flight Test Vehicle (AIX FTV) is described in this paper. The AIX FTV was designed to be representative of the Ares I Crew Launch Vehicle (CLV). While there are several differences in the outer mold line from the current revision of the CLV, the overall length, mass distribution, and flight systems of the two vehicles are very similar. This paper briefly touches on each of the aerodynamic databases developed in the program, describing the methodology employed, experimental and computational contributions to the generation of the databases, and how well the databases and underlying computations compare to actual flight test results

The ABA Model Statutory Close Corporation Act: A New Opportunity for Made In Montana Corporations

The ABA Model Statutory Close Corporation Act: A New Opportunity for Made In Montana Corporation

The ABA Model Statutory Close Corporation Act: A New Opportunity for Made In Montana Corporations

The ABA Model Statutory Close Corporation Act: A New Opportunity for Made In Montana Corporation

Utilization profile of the trauma intensive care unit at the Role 3 Multinational Medical Unit at Kandahar Airfield between May 1 and Oct. 15, 2009

Background: In the war against the Taliban, Canada was the lead North Atlantic Treaty Organization (NATO) nation to provide medical and surgical care to NATO soldiers, Afghanistan National Army soldiers, Afghanistan Nation Police, civilians working in and outside Kandahar Airfield and Afghanistan civilians at the Role 3 Multinational Medical Unit (R3MMU) from February 2006 to October 2009. Methods: We obtained data from the Joint Theatre Trauma Registry between May 1 and Oct. 15, 2009; 188 patients were admitted to the R3MMU intensive care unit (ICU). We analyzed the ICU data according to types and causes of trauma, mechanical ventilation prevalence, ICU medical and surgical complications, blood products utilization, length of stay in the ICU and mortality. Results: The admitting services were general surgery (35%), neurosurgery (29%), orthopedic surgery (18%) and internal medicine (3%). Improvised explosive devices (46%) and gunshot wounds (26%) were the main causes of ICU admissions. The mean injury severity score for all patients admitted to the ICU was 37, and 81% of ICU patients required mechanical ventilation for a mean duration of 3 days. The main ICU complications were coagulopathy (6.4%), aspiration pneumonia (4.3%), pneumothorax (3.7%) and wound infection (2.7%). The following blood products were most used: packed red blood cells (55%), fresh frozen plasma (54%), platelets (29%) and cryoprecipitate (23%). The average length of stay in the ICU was 4.3 days, and the survival rate was 93%. Conclusion: The high survival rate suggests that ICU care is a necessary and vital resource for a trauma hospital in a war zone

Resolving Holliday Junctions with Escherichia coli UvrD Helicase

The Escherichia coli UvrD helicase is known to function in the mismatch repair and nucleotide excision repair pathways and has also been suggested to have roles in recombination and replication restart. The primary intermediate DNA structure in these two processes is the Holliday junction. UvrD has been shown to unwind a variety of substrates including partial duplex DNA, nicked DNA, forked DNA structures, blunt duplex DNA and RNA-DNA hybrids. Here, we demonstrate that UvrD also catalyzes the robust unwinding of Holliday junction substrates. To characterize this unwinding reaction we have employed steady-state helicase assays, pre-steady-state rapid quench helicase assays, DNaseI footprinting, and electron microscopy. We conclude that UvrD binds initially to the junction compared with binding one of the blunt ends of the four-way junction to initiate unwinding and resolves the synthetic substrate into two double-stranded fork structures. We suggest that UvrD, along with its mismatch repair partners, MutS and MutL, may utilize its ability to unwind Holliday junctions directly in the prevention of homeologous recombination. UvrD may also be involved in the resolution of stalled replication forks by unwinding the Holliday junction intermediate to allow bypass of the blockage

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation of hPAR2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. In order to elucidate other post-translational modifications of hPAR2 that can regulate function, we have explored the functional role of the intracellular cysteine residue Cys361. We have demonstrated, using autoradiography, that Cys361 is the primary palmitoylation site of hPAR2. The hPAR2C361A mutant cell line displayed greater cell-surface expression compared with the wt (wild-type)-hPAR2-expressing cell line. hPAR2C361A also showed a decreased sensitivity and efficacy (intracellular calcium signalling) towards both trypsin and SLIGKV. In stark contrast, hPAR2C361A triggered greater and more prolonged ERK (extracellular-signal-regulated kinase) phosphorylation compared with that of wt-hPAR2 possibly through Gi, since pertussis toxin inhibited the ability of this receptor to activate ERK. Finally, flow cytometry was utilized to assess the rate and extent of receptor internalization following agonist challenge. hPAR2C361A displayed faster internalization kinetics following trypsin activation compared with wt-hPAR2, whereas SLIGKV had a negligible effect on internalization for either receptor. In conclusion, palmitoylation plays an important role in the regulation of PAR2 expression, agonist sensitivity, desensitization and internalization

SLS GNC Model-based Design Approach

No abstract availabl

The Grizzly, April 14, 1992

Ursinus Chooses Its Leaders • Viking Fiasco • Sieger Speaks • Economics Conference Held, Gilmour Wins Top Award • Songfest 1992 • Room Selection and Housing Update • The Perfect Day in Upper Perk • Carrot Top Captivates Crowd • Metallica Mosh Mania • French Speaks on Beethoven • The Sensual Sunbathers and Condom Machines • Choir Sings • Grubb\u27s Last Word • Viking Fest: The Other Side • Opinions Section Seeks New Assistants • Letter: What\u27s Done is Done • Men\u27s Lacrosse Starts Season with Three Straight Wins • Six UC Athletes Named Academic All-Conference • Baseball Wins Two Out of Threehttps://digitalcommons.ursinus.edu/grizzlynews/1295/thumbnail.jp

The Grizzly, April 16, 1991

Alcohol Policy Changes Discussed • Reimert Fire Breaks Up Sorority Rush: Deliberate or Accidental Still Unknown • Faculty Evaluates Frat Pledges Performance • Economics Conference Held • U.S.G.A. Minutes • Conflict and Creativity: ProTheatre Does it Again • Is Rock and Roll Really Dead? • REM: Out of Time • The Cider House Rules, Revisited • Religious Significance of David • Plaza Suite in Wismer • Jack Spinella Named New Basketball Coach • Men\u27s Track Falls to Hopkins • Men\u27s Lax Goes 1 and 1 This Week • Women Run Over Muhlenberg • Softball Splits • Golf Below Par • Student Input on Alcohol Policy Inadequate • Schafer Demands Opinion • Hold on to Your Key Money? • Letters: Apathy Dialog Proposed; Sorry, Harley; Thanks, Judd!; Weakly not Weekly • The Cutting Edge of Surgery • Electron Microscope to be Purchased With Kresge Grant • Help for Chronic Fatigue Sufferershttps://digitalcommons.ursinus.edu/grizzlynews/1276/thumbnail.jp