Preserving repository content: practical steps for repository managers

Few people would disagree that preservation of repository content is important. Indeed, the stated aim of most repositories is to provide permanent open access to the material therein. Why, then, have so few repositories implemented practical action plans for long term preservation of their content? There could be several reasons. Although a number of preservation tools and services already exist, until now few have addressed the specific needs of repositories; in practical terms they have necessitated action that is additional rather than integral to repository workflow. Repository content is typically highly varied and complex, while descriptive metadata and file formats are used inconsistently and deposited by those without knowledge or expertise in managing digital assets. Busy repository managers with little, if any, experience in digital preservation have lacked time and confidence to tackle what is perceived as an important but complex and scary problem. The JISC-funded KeepIt project is bringing together existing preservation tools and services with appropriate training and advice on preservation strategy, policy, costs, metadata, storage, format management and trust to enable the participating repository managers to formulate practical and achievable preservation plans. From the point of view of the repository manager, this presentation summarises the activities of the KeepIt project, describes the impact that the project has had on the participating repositories, and suggests steps that other repository managers might take to ensure preservation readiness

Using radio galaxies to find super-structures

Radio galaxies are excellent at tracing large-scale structure due to their high bias. We present new results from the TONS08 radio galaxy redshift survey. We find unequivocal evidence for a huge (at least 80 x 80 x 100 Mpc^3) super-structure at redshift z=0.27, confirming tentative evidence for such a structure from the 7C redshift survey (7CRS). A second, newly discovered super-structure is also tentatively found at redshift 0.35 (of dimensions at least 100 x 100 x 100 Mpc^3). Out of the total sample size of 84 radio galaxies, at least 25 are associated with the two super-structures. We use quasi-linear structure formation theory to estimate the number of such structures expected in the TONS08 volume if the canonical value for radio galaxy bias is assumed. Under this assumption, the structures represent ~ 4-5 sigma peaks in the primordial density field and their expected number is low (10^{-2}-10^{-4}). Fortunately, there are several plausible explanations (many of which are testable) for these low probabilities in the form of potential mechanisms for boosting the bias on large scales. These include: the association of radio galaxies with highly biased rich clusters in super-structures, enhanced triggering by group/group mergers, and enhanced triggering and/or redshift space distortion in collapsing systems as the growth of super-structures moves into the non-linear regime. Similar structures could have been missed in previous surveys because of the effects of Poisson-sampling fluctuations.Comment: 6 pages, 3 figures. To appear in "Radio galaxies: past, present and future", eds M. Jarvis et al., Leiden, Nov 200

Proceedings of the Workshop on Mitigating Coral Bleaching Impact Through MPA Design: 2001

Proceedings of a workshop to discuss coral reef research, monitoring, and marine protected area (MPA) management. It includes workshop summary information, specific papers presented during the event, and relevant appendixes

Coral Reefs: Threats and Conservation in an Era of Global Change

Coral reefs are iconic, threatened ecosystems that have been in existence for ∼500 million years, yet their continued ecological persistence seems doubtful at present. Anthropogenic modification of chemical and physical atmospheric dynamics that cause coral death by bleaching and newly emergent diseases due to increased heat and irradiation, as well as decline in calcification caused by ocean acidification due to increased CO2, are the most important large-scale threats. On more local scales, overfishing and destructive fisheries, coastal construction, nutrient enrichment, increased runoff and sedimentation, and the introduction of nonindigenous invasive species have caused phase shifts away from corals. Already ∼20% of the world\u27s reefs are lost and ∼26% are under imminent threat. Conservation science of coral reefs is well advanced, but its practical application has often been lagging. Societal priorites, economic pressures, and legal/administrative systems of many countries are more prone to destroy rather than conserve coral-reef ecosystems. Nevertheless, many examples of successful conservation exist from the national level to community-enforced local action. When effectively managed, protected areas have contributed to regeneration of coral reefs and stocks of associated marine resources. Local communities often support coral-reef conservation in order to raise income potential associated with tourism and/or improved resource levels. Coral reefs create an annual income in S-Florida alone of over $4 billion. Thus, no conflict between development, societal welfare, and coral-reef conservation needs to exist. Despite growing threats, it is not too late for decisive action to protect and save these economically and ecologically high-value ecosystems. Conservation science plays a critical role in designing effective strategies

Preserving repository content: practical steps for repository managers

From the point of view of the repository manager, this presentation summarises the activities of the KeepIt project, describes the impact that the project has had on the participating repositories, and suggests steps that other repository managers might take to ensure preservation readines

The cerebellum ages slowly according to the epigenetic clock

Studies that elucidate why some human tissues age faster than others may shed light on how we age, and ultimately suggest what interventions may be possible. Here we utilize a recent biomarker of aging (referred to as epigenetic clock) to assess the epigenetic ages of up to 30 anatomic sites from supercentenarians (subjects who reached an age of 110 or older) and younger subjects. Using three novel and three published human DNA methylation data sets, we demonstrate that the cerebellum ages more slowly than other parts of the human body. We used both transcriptional data and genetic data to elucidate molecular mechanisms which may explain this finding. The two largest superfamilies of helicases (SF1 and SF2) are significantly over-represented (p=9.2x10-9) among gene transcripts that are over-expressed in the cerebellum compared to other brain regions from the same subject. Furthermore, SNPs that are associated with epigenetic age acceleration in the cerebellum tend to be located near genes from helicase superfamilies SF1 and SF2 (enrichment p=5.8x10-3). Our genetic and transcriptional studies of epigenetic age acceleration support the hypothesis that the slow aging rate of the cerebellum is due to processes that involve RNA helicases