619 research outputs found

    Taking a Proposal Seriously : Orientations to Agenda and Agency in Support Workers’ Responses to Client Proposals

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    While joint decision-making is regularly launched by a proposal, it is the recipients’ responses that crucially influence the proposal outcome. This chapter examines how support workers respond to the proposals made by clients during rehabilitation group meetings at the Clubhouse. Drawing on a collection of 180 client-initiated proposal sequences, the paper describes two dilemmas that the support workers face when seeking to take client proposals “seriously.” The first concerns the meeting’s agenda and consists of a tension between providing recognition for the individual client and encouraging collective participation. The second dilemma has to do with agency and consists of a tension between focusing on the client as the originator of the proposal and avoiding treating him or her alone accountable for it. The analysis of these dilemmas contributes to a deeper understanding of group decision-making, in general, while these findings have specific relevance in mental health rehabilitation.While joint decision-making is regularly launched by a proposal, it is the recipients’ responses that crucially influence the proposal outcome. This chapter examines how support workers respond to the proposals made by clients during rehabilitation group meetings at the Clubhouse. Drawing on a collection of 180 client-initiated proposal sequences, the paper describes two dilemmas that the support workers face when seeking to take client proposals “seriously.” The first concerns the meeting’s agenda and consists of a tension between providing recognition for the individual client and encouraging collective participation. The second dilemma has to do with agency and consists of a tension between focusing on the client as the originator of the proposal and avoiding treating him or her alone accountable for it. The analysis of these dilemmas contributes to a deeper understanding of group decision-making, in general, while these findings have specific relevance in mental health rehabilitation.Peer reviewe

    Making identity assurance and authentication strength work for federated infrastructures

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    In both higher Research and Education (R&E) as well as in research-/ e-infrastructures (in short: infrastructures), federated access and single sign-on by way of national federations, operated in most cases by NRENs, are used as a means to provide users with access to a variety of services. Whereas in national federations institutional accounts, e.g. provided by a university, are typically used to access services, many infrastructures also accept other sources of identity: provided by \u27\u27community identity providers\u27\u27, social identity providers, or governmental IDs. In order to assess and communicate the quality of identities being used and authentications being performed, so called Level of Assurance (LoA) frameworks are used. Because sophisticated LoA frameworks like NIST 800-63-3, Kantara IAF 1420 or eIDAS regulation are often considered too complex to be used in R&E scenarios, the REFEDS Assurance Suite, a more lightweight approach, has been developed. To select an appropriate assurance level, Service Providers need to weigh risks and potential harms in relation to the kind of service they offer. However, the management of risks is often implicitly assumed and little or no guidance to determine the appropriate assurance level is given. In this paper, first, common LoA frameworks and their relation to risk management are investigated. Following that, their components are compared against the REFEDS Assurance Suite using a graphical representation. The focus of this paper lies in providing guidance and best practices based on example scenarios for both Service Providers to request the appropriate REFEDS assurance level, as well as for Identity Provider operators on how to implement REFEDS assurance components

    Detection and analysis of new psittacine beak and feather disease virus (PBFDv) nucleotide sequences

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    ΔΕΝ ΥΠΑΡΧΕΙ ΠΕΡΙΛΗΨΗPsittacine beak and feather disease (PBFD) affects a large number of Psittaciformes species. In this study, five White Cockatoo parrots (Cacatua alba) with clinical signs of PBFD were examined. After euthanasia, a full necropsy of parrots was performed and organs with macroscopic changes were sampled for routine histopathological evaluation. To confirm the presence of psittacine beak and feather disease virus (PBFDv), feather samples were analyzed with the PCR method. Sequence analysis of the obtained PCR products indicated their close relationship (99%) to other PBFDv isolates. Six variable nucleotide sites were discovered, two missense and four silent mutations. This paper presents the evidence of new PBFDv sequence in Cockatoo species

    Borna disease virus infects human neural progenitor cells and impairs neurogenesis.

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    Understanding the complex mechanisms by which infectious agents can disrupt behavior represents a major challenge. The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. Because BDV induces neurodegeneration in brain areas that are still undergoing maturation at the time of infection, we tested the hypothesis that BDV interferes with neurogenesis. We showed that human neural stem/progenitor cells are highly permissive to BDV, although infection does not alter their survival or undifferentiated phenotype. In contrast, upon the induction of differentiation, BDV is capable of severely impairing neurogenesis by interfering with the survival of newly generated neurons. Such impairment was specific to neurogenesis, since astrogliogenesis was unaltered. In conclusion, we demonstrate a new mechanism by which BDV might impair neural function and brain plasticity in infected individuals. These results may contribute to a better understanding of behavioral disorders associated with BDV infection

    Dynamics of wet flue gas desulphurization in spray absorber

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    A concise one dimensional thermal-hydraulic two-fluid model is presented for the numerical prediction of sulphur dioxide absorption from the flue gas onto drops of the water-limestone slurry in the vertical spray tower absorber. The model is based on mass, momentum and energy balance equations for each phase separately, i.e. downward falling droplets of water-limestone slurry and upward flowing flue gas. The sulphur dioxide content in the flue gas is predicted by a balance equation of the sulphur dioxide mass fraction in the flue gas. Interface transfer processes between the flue gas and the droplets are determined by closure laws. The obtained steady-state balance equations are transformed in a form suitable for a direct application of the numerical integration method for the system of ordinary differential equations. The developed thermal-hydraulic model is validated by comparing numerical results with available measured data at the large utility absorber. The presented results clearly show the dynamics of flue gas and droplets thermal-hydraulic processes and their influence on the absorption process

    Characterization of carbon fibrous material from platanus achenes as platinum catalysts support

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    Carbon materials with developed porosity are usually used as supports for platinum catalysts. Physico-chemical characteristics of the support influence the properties of platinum deposited and its catalytic activity. In our studies, we deposited platinum on carbon fibrous like materials obtained from platanus seeds - achenes. The precursor was chemically activated with different reagents: NaOH, pyrogallol, and H2O2, before the carbonization process. Platinum was deposited on all substrates to study the influence of the substrate properties on the activity of the catalyst. Carbon materials were characterized by nitrogen adsorption/desorption isotherms measurements, X-ray diffraction, and scanning electron microscopy. It was noticed that the adsorption characteristics of carbon support affected the structure of platinum deposits and thus their activity

    Numerical Investigation of Nucleate Pool Boiling Heat Transfer

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    Multi-dimensional numerical simulation of the atmospheric saturated pool boiling is performed. The applied modelling and numerical methods enable a full representation of the liquid and vapour two-phase mixture behaviour on the heated surface, with included prediction of the swell level and heated wall temperature field. In this way the integral behaviour of nucleate pool boiling is simulated. The micro conditions of bubble generation at the heated wall surface are modelled by the bubble nucleation site density, the liquid wetting contact angle and the bubble grow time. The bubble nucleation sites are randomly located within zones of equal size, where the number of zones equals the nucleation site density. The conjugate heat transfer from the heated wall to the liquid is taken into account in wetted heated wall areas around bubble nucleation sites. The boiling curve relation between the heat flux and the heated wall surface temperature in excess of the saturation temperature is predicted for the pool boiling conditions reported in the literature and a good agreement is achieved with experimentally measured data. The influence of the nucleation site density on the boiling curve characteristic is confirmed. In addition, the influence of the heat flux intensity on the spatial effects of vapour generation and two-phase flow are shown, such as the increase of the swell level position and the reduced wetting of the heated wall surface by the heat flux increase.17th Symposium of the Society-of-Thermal-Engineers-of-Serbia (SIMTERM), Oct 20-23, 2015, Sokobanja, Serbi

    Serbian KINDL questionnaire for quality of life assessments in healthy children and adolescents: reproducibility and construct validity

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    <p>Abstract</p> <p>Background</p> <p>The KINDL questionnaire is frequently used to evaluate quality of life (QOL) and the impacts of health conditions on children's everyday living. The objectives of this study were to assess the reproducibility and construct validity of the Serbian KINDL for QOL assessments in healthy children and adolescents.</p> <p>Methods</p> <p>Five hundred and sixty-four healthy children and adolescents completed the KINDL. Reproducibility was analyzed using the intraclass correlation coefficient (ICC). Confirmatory factor analysis (CFA) was performed to assess the structure of the KINDL construct validity.</p> <p>Results</p> <p>The intraclass correlation coefficients ranged from 0.03 to 0.84 for the subscales and total score. A second order CFA model as originally hypothesized was tested: items (24), primary factors (six subscales), and one secondary factor (QOL). The fit indexes derived from a CFA failed to yield appropriate fit between the data and the hypothesized model.</p> <p>Conclusion</p> <p>Majority of the subscales and total KINDL possess appropriate reproducibility for group comparisons. However, a CFA failed to confirm the structure of the original measurement model, indicating that the Serbian version should be revised before wider use for QOL assessments in healthy children and adolescent.</p

    Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells

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    Sox3/SOX3 is one of the earliest neural markers in vertebrates. Together with the Sox1/ SOX1 and Sox2/SOX2 genes it is implicated in the regulation of stem cell identity. In the present study, we performed the first analysis of epigenetic mechanisms (DNA methylation and histone marks) involved in the regulation of the human SOX3 gene expression during RA-induced neural differentiation of NT2/D1 cells. We show that the promoter of the human SOX3 gene is extremely hypomethylated both in undifferentiated NT2/D1 cells and during the early phases of RA-induced neural differentiation. By employing chromatin immunoprecipitation, we analyze several histone modifications across different regions of the SOX3 gene and their dynamics following initiation of differentiation. In the same timeframe we investigate profiles of selected histone marks on the promoters of human SOX1 and SOX2 genes. We demonstrate differences in histone signatures of SOX1, SOX2 and SOX3 genes. Considering the importance of SOXB1 genes in the process of neural differentiation, the present study contributes to a better understanding of epigenetic mechanisms implicated in the regulation of pluripotency maintenance and commitment towards the neural lineage
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