ЕФЕКТИВНІСТЬ НЕЙТРАЛІЗАЦІЙ ТРИВОЖНОСТІ У ДІТЕЙ, ЩО ХВОРІЮТЬ НА БРОНХІАЛЬНУ АСТМУ

The study of the effectiveness of the extended symptomatic treatment of bronchial asthma (BA) in school-age children, taking into account the individual characteristics of psychosomatic condition.The complex of art therapy that was added to standard therapy, was positively displaying by the reducing of the severity of anxiety in pediatric patients. In the process of learning proper breathing techniques of art therapy in patients with asthma decreased anxiety: personal at 58.33%, against 10.53% for the standard scheme and situational at 66.67% versus 10.53%, which  significantly ( p <0.05)  showed higher efficiency expanded symptomatic treatment.Проведено изучение эффективности расширенной симптоматической терапии бронхиальной астмы (БА) у детей школьного возраста с учетом индивидуальных особенностей психосоматического состояния. Комплекс арт-терапии добавленный к стандартной терапии позитивно отобразился на снижении выраженности тревожности у больных детей. В процессе обучения правильному дыханию методами арт-терапии у больных на БА уменьшилась тревожность: личностная у 58,33 %, против 10,53 % при стандартной схеме и ситуативная у 66,67 %, против 10,53 %, что достоверно (р<0,05) свидетельствует о более высокой эффективности расширенного симптоматического лечения.Проведено вивчення ефективності доповнення симптоматичного лікування бронхіальної астми (БА) арт-терапією у дітей шкільного віку з врахуванням індивідуальних особливостей психосоматичного стану. Арт-терапевтичний комплекс доданий до стандартної терапії позитивно вплинув на зниження виразності тривожності у хворих дітей. В процесі навчання правильному диханню засобами арт-терапії у хворих на БА зменшено тривожність: особистісну у 58,33 %, проти 10,53 % при стандартній схемі та ситуативну у 66,67 %, проти 10,53 %, що відображає достовірно (р<0,05) вищу ефективність доповненого симптоматичного лікування

Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells

Myeloid dendritic cells (DCs) play an important role in the immune response; therefore, the search for compounds that can effectively activate DCs is a needful goal. This study was aimed to investigate the effect of synthetic CpG oligodeoxynucleotides (CpG-ODN) on the maturation and allostimulatory activity of myeloid DCs in comparison with other PAMP and DAMP molecules. For the research, we synthesized known CpG-ODN class C (SD-101 and D-SL03) containing thiophosphate internucleotide groups, and their original phosphate-modified analogues (SD-101M and D-SL03M) with mesylphosphoramide internucleotide groups (M = μ-modification). The effects of CpG-ODN and other activators were evaluated on DCs generated from blood monocytes in the presence of GM-CSF and IFN-α (IFN-DC) or IL-4 (IL4-DC). Evaluation of the intracellular TLR-9 expression showed that both types of DCs (IFN-DC and IL4-DC) contained on average 52 and 80 % of TLR-9-positive cells, respectively. The CpG-ODNs studied enhanced the allostimulatory activity of IFN-DCs, and the effect of μ-modified CpG-ODNs was higher than that of CpG-ODNs with thiophosphate groups. The stimulating effect of CpG-ODN at a dose of 1.0 μg/ml was comparable (for D-SL03, D-SL03M, SD-101) with or exceeded (for SD-101M) the effect of LPS at a dose of 10 μg/ml. At the same time, IFN-DCs were characterized by greater sensitivity to the action of CpG-ODNs than IL4-DCs. The enhancement of DC allostimulatory activity in the presence of CpG-ODNs was associated with the induction of final DC maturation, which was confirmed by a significant decrease in the number of CD14+DC, an increase in mature CD83+DC and a trend towards an increase in CD86+DC. Interestingly, the characteristic ability of LPS to enhance the expression of the co-stimulatory molecule OX40L on DCs was revealed only for the μ-analogue SD-101M. In addition, CpG-ODNs (SD-101 and SD-101M) had a stimulatory effect on IFN-γ production comparable to the action of LPS. The data obtained indicate a stimulating effect of CpG-ODN on the maturation and allostimulatory activity of human myeloid DCs, which is more pronounced for μ-modified analogs

Magnetoelastic effects in low-dimensional magnetic systems

We consider a new realization of magnetoelastic interactions in low-dimensional magnetic systems. We show that low-dimensional spin systems are unstable with respect to the spontaneous appearance of alternating distortions of the positions of the three-dimensional nonmagnetic atoms (ligands), that surround the magnetic ions. Those distortions are supplemented by the spontaneous onset of alternating effective g factors of the magnetic ions in the phase with short-range interactions. We discuss the possibility of observing the effect in an uniform external magnetic field, which in the situation considered produces both magnetization and staggered magnetization of the magnetic subsystem. The connection of the proposed theory with recent experiments on effectively low-dimensional magnetic systems (organic spin chains, heavy-fermion compounds, rare-earth molybdates) is discussed

Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras

Alanyl-peptide nucleic acid (alanyl-PNA)/DNA chimeras are oligomers envisaged to be beneficial in efficient DNA diagnostics based on an improved molecular beacon concept. A synthesis of alanyl-PNA/DNA chimera can be based on the solid phase assembly of the oligomer with mixed oligonucleotide/peptide backbone under DNA synthesis conditions, in which the nucleotides are introduced as phosphoramidites, whereas the nucleo amino acids make use of the acid labile monomethoxytrityl (MMT) group for temporary protection of the α-amino groups and acyl protecting groups for the exocyclic amino functions of the nucleobases. In this work, we realized for the first time the synthesis of all four MMT/acyl-protected nucleo alanines, achieved by deprotection/reprotection of the newly synthesized Boc/acyl intermediates, useful monomers for the obtainment of (alanyl-PNA)/DNA chimeras by conditions fully compatible with the standard phosphoramidite DNA synthesis strategy

Comparative analysis of the size of dentition before and after orthodontic treatment crowding of teeth

С целью направленной регуляции процессов резорбции и остеогенеза костной ткани челюстей детям со скученностью зубов в период постоянного прикуса поэтапно назначали йодид калия, остеотропные препараты и адаптогены. В статье представлены результаты определения изменений размеров зубных рядов и сроков комплексного ортодонтического лечения детей со скученностью зубов. Полученные результаты стали основанием для рекомендаций по внедрению в стоматологическую практику разработанного лечебно-профилактического комплекса, позволяющего повысить эффективность и сократить сроки активного периода ортодонтического лечения.З метою спрямованої регуляції процесів резорбції і остеогенезу кісткової тканини щелеп дітям зі скупченістю зубів в період постійного прикусу поетапно призначали йодид калію, остеотропні препарати та адаптогени. У статті представлені результати визначення змін розмірів зубних рядів і термінів комплексного ортодонтичного лікування дітей зі скупченістю зубів. Отримані результати стали підставою для рекомендацій щодо впровадження в стоматологічну практику розробленого лікувально-профілактичного комплексу, що дозволяє підвищити ефективність і скоротити терміни активного періоду ортодонтичного лікування.In order directed regulation of bone resorption and bone jaw children with crowded teeth during permanent occlusion stages prescribed potassium iodide osteotropic drugs and adaptogens. Children main group underwent a comprehensive orthodontic treatment using adaptogens electrophoresis 2 % solution of potassium iodide in the movable teeth (for directional regulation simulation jaw bone) and 5 % solution of the drug "Osteovit" in the area of the abutment teeth to stabilize them. The results determine changes in the size and timing of dentition comprehensive orthodontic treatment for children with crowded teeth. The results were the basis for recommendations for implementation in dental practice developed preventive medical complex that improves the efficiency and shorten the period of active orthodontic treatment

Vygotsky in English: What Still Needs to Be Done

At present readers of English have still limited access to Vygotsky’s writings. Existing translations are marred by mistakes and outright falsifications. Analyses of Vygotsky’s work tend to downplay the collaborative and experimental nature of his research. Several suggestions are made to improve this situation. New translations are certainly needed and new analyses should pay attention to the contextual nature of Vygotsky’s thinking and research practice