Teaching, Learning, and Collaborating: Voices from Instructional Designers when Preparing Graduate Faculty for Online Instruction

The research sought to explore the experiences of eight instructional designers when preparing graduate faculty for online instruction and design

Adult Education-Related Graduate Degrees: Insights on the Challenges and Benefits of Online Programming

The qualitative study sought to explore the perspectives of faculty in developing and teaching on-line adult education courses in a master’s program. The Four Frame Model framed the research

Mental Health Professionals’ Perceptions of Referrals to School-Based Mental Services Among Elementary Students

AbstractBarriers exist to the referral process for mental-health services among elementary-school students from the perspective of school-based mental-health service professionals. The problem addressed in this study was that lack of mental-health referrals can delay or prevent treatment of mental-health issues, causing those mental-health problems to worsen over time. The purpose of this phenomenological study was to explore the lived experiences of school-based mental-health service professionals regarding these barriers to mental-health referrals. Pescosolido’s theory of the revised network model was the guiding conceptual framework for this study. The study was guided by research questions focused on how school-based mental-health professionals perceived barriers to student services and recommendations for addressing those barriers to mental health services. Seven elementary-school-based mental-health professionals were recruited through purposeful sampling and interviewed using a semistructured interview format. Moustakas’s steps to phenomenological research analysis were used to analyze the data and report emergent themes. The six themes that emerged from the data were difficulty scheduling, teachers’ misunderstanding or reluctance, stigma, education, increase availability, and streamline to care. These findings of the study can contribute to reducing barriers to the mental-health referral process among elementary school students. Positive social change may result from improved access to mental health services among elementary school students

Mental Health Professionals’ Perceptions of Referrals to School-Based Mental Services Among Elementary Students

AbstractBarriers exist to the referral process for mental-health services among elementary-school students from the perspective of school-based mental-health service professionals. The problem addressed in this study was that lack of mental-health referrals can delay or prevent treatment of mental-health issues, causing those mental-health problems to worsen over time. The purpose of this phenomenological study was to explore the lived experiences of school-based mental-health service professionals regarding these barriers to mental-health referrals. Pescosolido’s theory of the revised network model was the guiding conceptual framework for this study. The study was guided by research questions focused on how school-based mental-health professionals perceived barriers to student services and recommendations for addressing those barriers to mental health services. Seven elementary-school-based mental-health professionals were recruited through purposeful sampling and interviewed using a semistructured interview format. Moustakas’s steps to phenomenological research analysis were used to analyze the data and report emergent themes. The six themes that emerged from the data were difficulty scheduling, teachers’ misunderstanding or reluctance, stigma, education, increase availability, and streamline to care. These findings of the study can contribute to reducing barriers to the mental-health referral process among elementary school students. Positive social change may result from improved access to mental health services among elementary school students

On the linear fractional self-attracting diffusion

In this paper, we introduce the linear fractional self-attracting diffusion driven by a fractional Brownian motion with Hurst index 1/2<H<1, which is analogous to the linear self-attracting diffusion. For 1-dimensional process we study its convergence and the corresponding weighted local time. For 2-dimensional process, as a related problem, we show that the renormalized self-intersection local time exists in L^2 if $\frac12<H<\frac3{4}$.Comment: 14 Pages. To appear in Journal of Theoretical Probabilit

Short-term disuse does not affect postabsorptive or postprandial muscle protein fractional breakdown rates

This is the final version. Available on open access from Wiley via the DOI in this recordBACKGROUND: The decline in postabsorptive and postprandial muscle protein fractional synthesis rates (FSR) does not quantitatively account for muscle atrophy during uncomplicated, short-term disuse, when atrophy rates are the highest. We sought to determine whether 2 days of unilateral knee immobilization affects mixed muscle protein fractional breakdown rates (FBR) during postabsorptive and simulated postprandial conditions. METHODS: Twenty-three healthy, male participants (age: 22 ± 1 year; height: 179 ± 1 cm; body mass: 73.4 ± 1.5 kg; body mass index 22.8 ± 0.5 kg·m-2 ) took part in this randomized, controlled study. After 48 h of unilateral knee immobilization, primed continuous intravenous l-[15 N]-phenylalanine and l-[ring-2 H5 ]-phenylalanine infusions were used for parallel determinations of FBR and FSR, respectively, in a postabsorptive (saline infusion; FAST) or simulated postprandial state (67.5 mg·kg body mass-1 ·h-1 amino acid infusion; FED). Bilateral m. vastus lateralis biopsies from the control (CON) and immobilized (IMM) legs, and arterialized-venous blood samples, were collected throughout. RESULTS: Amino acid infusion rapidly increased plasma phenylalanine (59 ± 9%), leucine (76 ± 5%), isoleucine (109 ± 7%) and valine (42 ± 4%) concentrations in FED only (all P  0.05). However, immobilization decreased FSR (P < 0.05) in both FAST (0.071 ± 0.004 vs. 0.086 ± 0.007%·h-1 ; IMM vs CON, respectively) and FED (0.066 ± 0.016 vs. 0.119 ± 0.016%·h-1 ; IMM vs CON, respectively). Consequently, immobilization decreased net muscle protein balance (P < 0.05) and to a greater extent in FED (CON: -0.012 ± 0.025; IMM: -0.095 ± 0.023%·h-1 ; P < 0.05) than FAST (CON: -0.064 ± 0.020; IMM: -0.072 ± 0.017%·h-1 ). CONCLUSIONS: We conclude that merely 2 days of leg immobilization does not modulate postabsorptive and simulated postprandial muscle protein breakdown rates. Instead, under these conditions the muscle negative muscle protein balance associated with brief periods of experimental disuse is driven near exclusively by reduced basal muscle protein synthesis rates and anabolic resistance to amino acid administration.Nutricia Research FoundationUniversity of ExeterBeachbody LLCNational Institute of Agin

Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance

Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components of innate immunity in human serum that protect against infection by other African trypanosomes. In Tbr, lytic activity is suppressed by the Tbr-specific serum-resistance associated (SRA) protein. The mechanism in Tbg is less well understood but has been hypothesized to involve altered activity and expression of haptoglobin haemoglobin receptor (HpHbR). HpHbR has been shown to facilitate internalization of TLF-1 in T.b. brucei (Tbb), a member of the T. brucei species complex that is susceptible to human serum. By evaluating the genetic variability of HpHbR in a comprehensive geographical and taxonomic context, we show that a single substitution that replaces leucine with serine at position 210 is conserved in the most widespread form of Tbg (Tbg group 1) and not found in related taxa, which are either human serum susceptible (Tbb) or known to resist lysis via an alternative mechanism (Tbr and Tbg group 2). We hypothesize that this single substitution contributes to reduced uptake of TLF and thus may play a key role in conferring serum resistance to Tbg group 1. In contrast, similarity in HpHbR sequence among isolates of Tbg group 2 and Tbb/Tbr provides further evidence that human serum resistance in Tbg group 2 is likely independent of HpHbR functio