258 research outputs found
Optimal foraging: Some simple stochastic models.
Some simple stochastic models of optimal foraging are considered. Firstly, mathematical renewal theory is used to make a general model of the combined processes of search, encounter, capture and handling. In the case where patches or prey items are encountered according to a Poisson process, the limiting probability distribution of energy gain is found. This distribution is found to be normal and its mean and variance are specified. This result supports the use of Hollings disc equation to specify the rate of energy intake in foraging models. Secondly, a model based on minimization of the probability of death due to an energetic shortfall is presented. The model gives a graphical solution to the problem of optimal choices when mean and variance are related. Thirdly, a worked example using these results is presented. This example suggests that there may be natural relationships between mean and variance which makes solutions to the problems of \u27energy maximization\u27 and \u27minimization of the probability of starvation\u27 similar. Finally, current trends in stochastic modeling of foraging behavior are critically discussed
Development and AFM study of porous scaffolds for wound healing applications
An engineering approach to the development of biomaterials for promotion of wound healing emphasises the importance
of a well-controlled architecture and concentrates on optimisation of morphology and surface chemistry to stimulate
guidance of the cells within the wound environment. A series of three-dimensional porous scaffolds with 80–90% bulk porosity
and fully interconnected macropores were prepared from two biodegradable materials – cellulose acetate (CA) and poly (lacticco-glycolic
acid) (PLGA) through the phase inversion mechanism of formation. Surface morphology of obtained scaffolds
was determined using atomic force microscopy (AFM) in conjunction with optical microscopy. Scanning Electron Microscopy
(SEM) was applied to characterise scaffolds bulk morphology. Biocompatibility and biofunctionality of the prepared materials
were assessed through a systematic study of cell/material interactions using atomic force microscopy (AFM) methodologies together
with in vitro cellular assays. Preliminary data with human fibroblasts demonstrated a positive influence of both scaffolds
on cellular attachment and growth. The adhesion of cells on both biomaterials were quantified by AFM force measurements in
conjunction with a cell probe technique since, for the first time, a fibroblast probe has been successfully developed and optimal
conditions of immobilisation of the cells on the AFM cantilever have been experimentally determined
Mott Transition in Degenerate Hubbard Models: Application to Doped Fullerenes
The Mott-Hubbard transition is studied for a Hubbard model with orbital
degeneracy N, using a diffusion Monte-Carlo method. Based on general arguments,
we conjecture that the Mott-Hubbard transition takes place for U/W \propto
\sqrt{N}, where U is the Coulomb interaction and W is the band width. This is
supported by exact diagonalization and Monte-Carlo calculations. Realistic
parameters for the doped fullerenes lead to the conclusion that stoichiometric
A_3 C_60 (A=K, Rb) are near the Mott-Hubbard transition, in a correlated
metallic state.Comment: 4 pages, revtex, 1 eps figure included, to be published in Phys.Rev.B
Rapid Com
Design, Commissioning and Performance of the PIBETA Detector at PSI
We describe the design, construction and performance of the PIBETA detector
built for the precise measurement of the branching ratio of pion beta decay,
pi+ -> pi0 e+ nu, at the Paul Scherrer Institute. The central part of the
detector is a 240-module spherical pure CsI calorimeter covering 3*pi sr solid
angle. The calorimeter is supplemented with an active collimator/beam degrader
system, an active segmented plastic target, a pair of low-mass cylindrical wire
chambers and a 20-element cylindrical plastic scintillator hodoscope. The whole
detector system is housed inside a temperature-controlled lead brick enclosure
which in turn is lined with cosmic muon plastic veto counters. Commissioning
and calibration data were taken during two three-month beam periods in
1999/2000 with pi+ stopping rates between 1.3*E3 pi+/s and 1.3*E6 pi+/s. We
examine the timing, energy and angular detector resolution for photons,
positrons and protons in the energy range of 5-150 MeV, as well as the response
of the detector to cosmic muons. We illustrate the detector signatures for the
assorted rare pion and muon decays and their associated backgrounds.Comment: 117 pages, 48 Postscript figures, 5 tables, Elsevier LaTeX, submitted
to Nucl. Instrum. Meth.
The Value of Information for Populations in Varying Environments
The notion of information pervades informal descriptions of biological
systems, but formal treatments face the problem of defining a quantitative
measure of information rooted in a concept of fitness, which is itself an
elusive notion. Here, we present a model of population dynamics where this
problem is amenable to a mathematical analysis. In the limit where any
information about future environmental variations is common to the members of
the population, our model is equivalent to known models of financial
investment. In this case, the population can be interpreted as a portfolio of
financial assets and previous analyses have shown that a key quantity of
Shannon's communication theory, the mutual information, sets a fundamental
limit on the value of information. We show that this bound can be violated when
accounting for features that are irrelevant in finance but inherent to
biological systems, such as the stochasticity present at the individual level.
This leads us to generalize the measures of uncertainty and information usually
encountered in information theory
Stochastic Production Of Kink-Antikink Pairs In The Presence Of An Oscillating Background
We numerically investigate the production of kink-antikink pairs in a
dimensional field theory subject to white noise and periodic driving.
The twin effects of noise and periodic driving acting in conjunction lead to
considerable enhancement in the kink density compared to the thermal
equilibrium value, for low dissipation coefficients and for a specific range of
frequencies of the oscillating background. The dependence of the kink-density
on the temperature of the heat bath, the amplitude of the oscillating
background and value of the dissipation coefficient is also investigated. An
interesting feature of our result is that kink-antikink production occurs even
though the system always remains in the broken symmetry phase.Comment: Revtex, 21 pages including 7 figures; more references adde
Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning
The up-regulation of α4β2* nicotinic acetylcholine receptors (nAChRs) by chronic nicotine is a cell-delimited process and may be necessary and sufficient for the initial events of nicotine dependence. Clinical literature documents an inverse relationship between a person’s history of tobacco use and his or her susceptibility to Parkinson’s disease; this may also result from up-regulation. This study visualizes and quantifies the subcellular mechanisms involved in nicotine-induced nAChR up-regulation by using transfected fluorescent protein (FP)-tagged α4 nAChR subunits and an FP-tagged Sec24D endoplasmic reticulum (ER) exit site marker. Total internal reflection fluorescence microscopy shows that nicotine (0.1 µM for 48 h) up-regulates α4β2 nAChRs at the plasma membrane (PM), despite increasing the fraction of α4β2 nAChRs that remain in near-PM ER. Pixel-resolved normalized Förster resonance energy transfer microscopy between α4-FP subunits shows that nicotine stabilizes the (α4)2(β2)3 stoichiometry before the nAChRs reach the trans-Golgi apparatus. Nicotine also induces the formation of additional ER exit sites (ERES). To aid in the mechanistic analysis of these phenomena, we generated a β2enhanced-ER-export mutant subunit that mimics two regions of the β4 subunit sequence: the presence of an ER export motif and the absence of an ER retention/retrieval motif. The α4β2enhanced-ER-export nAChR resembles nicotine-exposed nAChRs with regard to stoichiometry, intracellular mobility, ERES enhancement, and PM localization. Nicotine produces only small additional PM up-regulation of α4β2enhanced-ER-export receptors. The experimental data are simulated with a model incorporating two mechanisms: (1) nicotine acts as a stabilizing pharmacological chaperone for nascent α4β2 nAChRs in the ER, eventually increasing PM receptors despite a bottleneck(s) in ER export; and (2) removal of the bottleneck (e.g., by expression of the β2enhanced-ER-export subunit) is sufficient to increase PM nAChR numbers, even without nicotine. The data also suggest that pharmacological chaperoning of nAChRs by nicotine can alter the physiology of ER processes
Diet of two syntopic species of Crenuchidae (Ostariophysi: Characiformes) in an Amazonian rocky stream
Abstract This study assessed the diet of two poorly known syntopic fish species of the family Crenuchidae, Characidium aff. declivirostre and Leptocharacidium omospilus, in a Presidente Figueiredo´ rocky stream, Amazonas, Brazil. The stomach contents were analyzed and their Frequency of Occurrence (FO %) and Relative Volume (Vol %) were combined in a Feeding Index (IAi). We examined 20 individuals of C. aff. declivirostre and 23 of L. omospilus. The Morisita-Horn Index was used to estimate the overlap between the diets of these species. Immature insects were the most valuable items consumed by both fish species. The diet of C. aff. declivirostre was mainly composed of larvae and pupae of Chironomidae, while L. omospilus predominantly consumed larvae of Hydroptilidae, Hydropyschidae and Pyralidae. Thus, both species were classified as autochthonous insectivorous. Characidium aff. declivirostre was considered a more specialized species, probably reflecting lower feeding plasticity or the use of more restricted microhabitats compared to L. omospilus. When the food items were analyzed at the family taxonomic level, the diet overlap between these species was considered moderate (Morisita-Horn Index = 0.4). However, a more thorough analysis, at the genus level, indicates a very low diet overlap. Therefore, we conclude that the feeding segregation between C. aff. declivirostre and L. omospilus may favor their co-existence, despite their high phylogenetic closeness
TESS Reveals HD 118203 b to be a Transiting Planet
The exoplanet HD 118203 b, orbiting a bright (V = 8.05) host star, was discovered using the radial velocity method by da Silva et al., but was not previously known to transit. Transiting Exoplanet Survey Satellite (TESS) photometry has revealed that this planet transits its host star. Nine planetary transits were observed by TESS, allowing us to measure the radius of the planet to be 1.136-0.028 +0.029 R J, and to calculate the planet mass to be 2.166-0.079 +0.074 M J. The host star is slightly evolved with an effective temperature of T eff=5683-85 +84 K and a surface gravity of log\,g=3.889 0.018-0.017. With an orbital period of 6.134985-0.000030 +0.000029 days and an eccentricity of 0.314 ± 0.017, the planet occupies a transitional regime between circularized hot Jupiters and more dynamically active planets at longer orbital periods. The host star is among the 10 brightest known to have transiting giant planets, providing opportunities for both planetary atmospheric and asteroseismic studies
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