Igneous sills record far-field and near-field stress interactions during volcano construction: Isle of Mull, Scotland

Sill emplacement is typically associated with horizontally mechanically layered host rocks in a near-hydrostatic far-field stress state, where contrasting mechanical properties across the layers promote transitions from dykes, or inclined sheets, to sills. We used detailed field observations from the Loch Scridain Sill Complex (Isle of Mull, UK), and mechanical models to show that layering is not always the dominant control on sill emplacement. The studied sills have consistently shallow dips (1°–25°) and cut vertically bedded and foliated metamorphic basement rocks, and horizontally bedded cover sedimentary rocks and lavas. Horizontal and shallowly-dipping fractures in the host rock were intruded with vertical opening in all cases, whilst steeply-dipping discontinuities within the sequence (i.e. vertical fractures and foliation in the basement, and vertical polygonal joints in the lavas) were not intruded during sill emplacement. Mechanical models of slip tendency, dilation tendency, and fracture susceptibility for local and overall sill geometry data, support a radial horizontal compression during sill emplacement. Our models show that dykes and sills across Mull were emplaced during NW–SE horizontal shortening, related to a far-field tectonic stress state. The dykes generally accommodated phases of NE–SW horizontal tectonic extension, whereas the sills record the superposition of the far-field stress with a near-field stress state, imposed by emplacement of the Mull Central Volcano. We show that through detailed geometric characterisation coupled with mechanical modelling, sills may be used as an indication of fluctuations in the paleostress state

Coupling Of Ribosome And tRNA Dynamics During Translation

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Mutations of the BRAF gene in human cancer

Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis signalling pathways in which at least one gene is mutated in human cancer. The RAS RAF MEK ERK MAP kinase pathway mediates cellular responses to growth signals. RAS is mutated to an oncogenic form in about 15% of human cancer. The three RAF genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. All mutations are within the kinase domain, with a single substitution (V599E) accounting for 80%. Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma

Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV

We report the results of a study of color coherence effects in ppbar collisions based on data collected by the D0 detector during the 1994-1995 run of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8 TeV. Initial-to-final state color interference effects are studied by examining particle distribution patterns in events with a W boson and at least one jet. The data are compared to Monte Carlo simulations with different color coherence implementations and to an analytic modified-leading-logarithm perturbative calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters

Lifetime measurement in excited and yrast superdeformed bands in Hg194

Nuclear level lifetimes have been measured in two superdeformed bands in Hg194 using the Doppler-shift attenuation method. Average transition quadrupole moments derived from the lifetimes of an excited and yrast superdeformed bands are Qt=17.6(30) and 17.2(20)eb, respectively. The Doppler shifts of the excited band relative to the yrast band indicate a slight difference in quadrupole moments [+4(5)%], assuming similar side feeding..ul2 These results imply that the second well is stable and rigid with respect to the particle excitation responsible for this excited band

Identification of the unfavored N=7 superdeformed band in Hg191

A new superdeformed band has been identified in Hg191 bringing the total number of bands observed in this nucleus to four. The new band has properties similar to those of a superdeformed band reported recently in Hg193. Both bands are believed to be built on the unfavored signature of the j15/2 intruder configuration. Comparisons between the data and cranked Woods-Saxon calculations highlight the strengths and weaknesses of theory in describing high-N orbitals at large deformation

Structure of superdeformed bands in 195Hg

Four new superdeformed bands have been observed with the Gammasphere array and have been assigned to the 195Hg nucleus. Two of the bands are interpreted as signature partners most likely based on Nosc6 neutron quasiparticles coupled to a superdeformed core, while the other two appear to be based on a j15/2 intruder orbital. These four bands do not exhibit a simple, ``identical bands'' relationship to other superdeformed bands in this mass region

New features of superdeformed bands in Hg194

Two new features of superdeformed (SD) bands in the A190 region emerge from a study of Hg194 with the Gammasphere detector array. A decrease of the dynamic moment of inertia is observed for rotational frequencies Latin small letter h with strokeω0.4 MeV, confirming long standing expectations based on mean field calculations with pairing. Evidence for a small staggering in the SD transition energies is also observed, suggesting the presence of terms with fourfold symmetry in the SD Hamiltonian

High-angular-momentum structures in 64Zn

High-angular-momentum states in 64Zn were populated in the 40Ca( 28Si,4p) reaction at a beam energy of 122 MeV. Evaporated, light, charged particles were identified by the Microball, while γ rays were detected using the Gammasphere array. The main focus of this paper is on two strongly coupled, collective bands. The yrast band, which was previously known, has been linked to lower-lying states establishing the excitation energies and angular momenta of in-band states for the first time. The newly identified excited band decays to the yrast band but firm angular-momentum assignments could not be made. In order to interpret these structures cranked-Nilsson-Strutinsky calculations have been performed. The calculations have been extended to account for the distribution of nucleons within a configuration. The yrast collective band is interpreted as based on the π(f 7/2) -1(p 3/2f 5/2) 2(g 9/2) 1 ν(p 3/2f 5/2) 4(g 9/2) 2 configuration. There are several possible interpretations of the second band but it is difficult to distinguish between the different possibilities