Manufacture of Compliant Prosthesis Sockets using Selective Laser Sintering 565

Solid Freeform Fabrication to date has largely been applied in prototype fabrication or fabrication of patterns for conventional manufacturing methods. However, many opportunities exist for using SFF for manufacturing the actual product. In particular, those applications that require or can be enhanced by custom geometric design seem to be well suited for SFF techniques. In this paper we describe the design of a prosthesis socket for a below-the-knee amputee. This socket is specifically designed to provide compliance in selected areas to enhance the comfort of the wearer. Additionally, the socket contains an integrated pylon fitting that provides a structurally superior connection while also improving the comfort of the wearer. The socket was manufactured using selective laser sintering, mated to a pylon and foot, and fitted to the patient for gait analysis. The results of the analysis indicate an improved fit is possible with manufacture by SLS.The authors acknowledge the support of the Veterans Administration for partial support of this work.Mechanical Engineerin

Psychedelics and workplace harm

This study aims to understand the relationship between Lifetime Classic Psychedelic Use (LCPU), employment status, and weekly work hours on levels of psychological distress. The data used for this analysis is pooled from the National Survey of Drug Use and Health (NSDUH) from 2008–2019 and includes a sample size of 484,732 individuals. The findings suggest that LCPU and being employed are independently associated with better health. Additionally, the results indicate that psychedelic use is associated with lower distress for those who are employed, volunteer, retired, or permanently disabled. However, those who are unemployed, full-time students, or homemakers may experience higher levels of distress with psychedelic use. Interestingly, the analysis also suggests that those who use psychedelics are working longer hours per week before experiencing an increase in stress. Overall, the study suggests that psychedelics are not likely to have a negative impact on employment outcomes

The Importance of Direct and Indirect Trophic Interactions in Determining the Presence of a Locally Rare Day-Flying Moth

Ecosystem engineers affect other organisms by creating, maintaining or modifying habitats, potentially supporting species of conservation concern. However, it is important to consider these interactions alongside non-engineering trophic pathways. We investigated the relative importance of trophic and non-trophic effects of an ecosystem engineer, red deer, on a locally rare moth, the transparent burnet ( Zygaena purpuralis ). This species requires specific microhabitat conditions, including the foodplant, thyme, and bare soil for egg-laying. The relative importance of grazing (i.e., trophic effect of modifying microhabitat) and trampling (i.e., non-trophic effect of exposing bare soil) by red deer on transparent burnet abundance are unknown. We tested for these effects using a novel method of placing pheromone-baited funnel traps in the field. Imago abundance throughout the flight season was related to plant composition, diversity and structure at various scales around each trap. Indirect effects of red deer activity were accounted for by testing red deer pellet and trail presence against imago abundance. Imago abundance was positively associated with thyme and plant diversity, whilst negatively associated with velvet grass and heather species cover. The presence of red deer pellets and trails were positively associated with imago abundance. The use of these sites by red deer aids the transparent burnet population via appropriate levels of grazing and the provision of a key habitat condition, bare soil, in the form of deer trails. This study shows that understanding how both trophic and non-trophic interactions affect the abundance of a species provides valuable insights regarding conservation objectives

New bottle or new label? Distinguishing impact investing from responsible and ethical investing

A common topic of debate in academic scholarship on impact, ethical, and responsible investing is definitional clarity around the motivations and applications of each form of investment strategy. We ask, how does the subfield of impact investing differentiate itself from more established ethical and responsible investing – and do these differences necessitate yet another field of study? Adopting a combination of bibliometric and content analyses, we identify four distinct features of impact investing – positive impact targeting, novelty of governance structures, long time horizons, and the importance of philanthropy

Complementarity Endures: No Firewall for an Infalling Observer

We argue that the complementarity picture, as interpreted as a reference frame change represented in quantum gravitational Hilbert space, does not suffer from the "firewall paradox" recently discussed by Almheiri, Marolf, Polchinski, and Sully. A quantum state described by a distant observer evolves unitarily, with the evolution law well approximated by semi-classical field equations in the region away from the (stretched) horizon. And yet, a classical infalling observer does not see a violation of the equivalence principle, and thus a firewall, at the horizon. The resolution of the paradox lies in careful considerations on how a (semi-)classical world arises in unitary quantum mechanics describing the whole universe/multiverse.Comment: 11 pages, 1 figure; clarifications and minor revisions; v3: a small calculation added for clarification; v4: some corrections, conclusion unchange

SRAdb: query and use public next-generation sequencing data from within R

Abstract Background The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the next generation of sequencing platforms including Illumina (Genome Analyzer, HiSeq, MiSeq, .etc), Roche 454 GS System, Applied Biosystems SOLiD System, Helicos Heliscope, PacBio RS, and others. Results SRAdb is an attempt to make queries of the metadata associated with SRA submission, study, sample, experiment and run more robust and precise, and make access to sequencing data in the SRA easier. We have parsed all the SRA metadata into a SQLite database that is routinely updated and can be easily distributed. The SRAdb R/Bioconductor package then utilizes this SQLite database for querying and accessing metadata. Full text search functionality makes querying metadata very flexible and powerful. Fastq files associated with query results can be downloaded easily for local analysis. The package also includes an interface from R to a popular genome browser, the Integrated Genomics Viewer. Conclusions SRAdb Bioconductor package provides a convenient and integrated framework to query and access SRA metadata quickly and powerfully from within R.</p

The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus

Gliotoxin, a redox-active metabolite, is produced by the opportunistic fungal pathogen Aspergillus fumigatus, and its biosynthesis is directed by the gli gene cluster. Knowledge of the biosynthetic pathway to gliotoxin, which contains a disulfide bridge of unknown origin, is limited, although L-Phe and L-Ser are known biosynthetic precursors. Deletion of gliG from the gli cluster, herein functionally confirmed as a glutathione S-transferase, results in abrogation of gliotoxin biosynthesis and accumulation of 6-benzyl-6-hydroxy-1-methoxy-3-methylenepiperazine- 2,5-dione. This putative shunt metabolite from the gliotoxin biosynthetic pathway contains an intriguing hydroxyl group at C-6, consistent with a gliotoxin biosynthetic pathway involving thiolation via addition of the glutathione thiol group to a reactive acyl imine intermediate. Complementation of gliG restored gliotoxin production and, unlike gliT, gliG was found not to be involved in fungal self-protection against gliotoxin

The impact of equilibrating hemispheric albedos on tropical performance in the HadGEM2-ES coupled climate model

AcceptedArticle in Press©2015. The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.©2015. The Authors. The Earth's hemispheric reflectances are equivalent to within±0.2Wm-2, even though the Northern Hemisphere contains a greater proportion of higher reflectance land areas, because of greater cloud cover in the Southern Hemisphere. This equivalence is unlikely to be by chance, but the reasons are open to debate. Here we show that equilibrating hemispheric albedos in the Hadley Centre Global Environment Model version 2-Earth System coupled climate model significantly improves what have been considered longstanding and apparently intractable model biases. Monsoon precipitation biases over all continental land areas, the penetration of monsoon rainfall across the Sahel, the West African monsoon "jump", and indicators of hurricane frequency are all significantly improved. Mechanistically, equilibrating hemispheric albedos improves the atmospheric cross-equatorial energy transport and increases the supply of tropical atmospheric moisture to the Hadley cell. We conclude that an accurate representation of the cross-equatorial energy transport appears to be critical if tropical performance is to be improved

Understanding the ongoing learning needs of Australian metropolitan, rural and remote paediatricians: Evaluation of a neurology outreach programme

Aim: The purpose of this study was to evaluate whether a neurology outreach teaching programme delivered via video-teleconferencing (6 × 60 min live sessions every 6–8 weeks) is acceptable, contributes to understanding and meets the neurology learning needs of Australian paediatricians from metropolitan, rural and remote areas. Methods: A sample of six NSW sites that joined the neurology outreach programme between 2017 and 2019 (Arm 1) and six interstate sites from QLD, WA and TAS who commenced the programme in 2020 (Arm 2) participated. A mixed-methods survey explored participants' learning needs and value of the programme. Results: Forty-six participants submitted programme evaluation surveys (26 arm 1, 20 arm 2); 9 were removed due to insufficient data (n = 37). Quantitative and qualitative data showed the programme was acceptable in format, relevant to practice, appropriate for clinician learning needs, and engaging. Clinicians reported improvement in understanding and confidence. Participants felt more connected/less isolated and up-to-date. Participants reported a positive impact from the programme on approach to neurological problems and ensuing consults, and more differentiated and appropriate paediatric neurology referrals. Conclusion: This study validates the live video-teleconference outreach model as an acceptable, effective and important means of providing continuing neurology education for Australian paediatricians