Finding Refuge in King Lear: From Brexit to Shakespeare’s European Value

This article considers how Shakespeare’s King Lear has become a Brexit play across a range of discourses and media, from theatre productions and journalism to social media. With its themes of division and disbursement, of cliff edges and tragic self-immolation, Lear is the Shakespearean play that has been turned to as metaphor and analogy for the UK’s decision following the 23 June 2016 referendum to leave the European Union. Reading this presentist application of Shakespeare, the article attends to Shakespeare as itself a discourse through which cultural ideas, both real and imaginary, about Brexit and the EU are negotiated. It asks how can we might remap Lear in this present context―what other meanings and histories are to be derived from the play, especially in Lear’s exile and search for refuge, or in Cordelia’s departure for and return from France? Moving from a consideration of a Brexit Lear to an archipelagic and even European Lear, this article argues that Shakespeare is simultaneously a site of supranational connections and of a desire for values of empathy and refuge that reverberate with debates about migration in Europe

Solution-processed bilayer photovoltaic devices with nematic liquid crystals

The cross-linking of polymerisable liquid crystalline semiconductors is a promising approach to solution-processable, multilayer, organic photovoltaics. Here we demonstrate an organic bilayer photovoltaic with an insoluble electron-donating layer formed by cross-linking a nematic reactive mesogen. We investigate a range of perylene diimide (PDI) materials, some of which are liquid crystalline, as the overlying electron acceptor layer. We find that carrier mobility of the acceptor materials is enhanced by liquid crystallinity and that mobility limits the performance of photovoltaic devices. © 2013 © 2013 Taylor & Francis

Mean curvature flow and quasilocal mass for two-surfaces in Hamiltonian General Relativity

A family of quasilocal mass definitions that includes as special cases the Hawking mass and the Brown-York ``rest mass'' energy is derived for spacelike 2-surfaces in spacetime. The definitions involve an integral of powers of the norm of the spacetime mean curvature vector of the 2-surface, whose properties are connected with apparent horizons. In particular, for any spacelike 2-surface, the direction of mean curvature is orthogonal (dual in the normal space) to a unique normal direction in which the 2-surface has vanishing expansion in spacetime. The quasilocal mass definitions are obtained by an analysis of boundary terms arising in the gravitational ADM Hamiltonian on hypersurfaces with a spacelike 2-surface boundary, using a geometric time-flow chosen proportional to the dualized mean curvature vector field at the boundary surface. A similar analysis is made choosing a geometric rotational flow given in terms of the twist covector of the dual pair of mean curvature vector fields, which leads to a family of quasilocal angular momentum definitions involving the squared norm of the twist. The large sphere limit of these definitions is shown to yield the ADM mass and angular momentum in asymptotically flat spacetimes, while at apparent horizons a quasilocal version of the Gibbons-Penrose inequality is derived. Finally, some results concerning positivity are proved for the quasilocal masses, motivated by consideration of spacelike mean curvature flow of 2-surfaces in spacetime.Comment: Revised version, includes an analysis of null flows with applications to mass and angular momentum for apparent horizon

Estimating causal effects : considering three alternatives to difference-in-differences estimation

Difference-in-differences (DiD) estimators provide unbiased treatment effect estimates when, in the absence of treatment, the average outcomes for the treated and control groups would have followed parallel trends over time. This assumption is implausible in many settings. An alternative assumption is that the potential outcomes are independent of treatment status, conditional on past outcomes. This paper considers three methods that share this assumption: the synthetic control method, a lagged dependent variable (LDV) regression approach, and matching on past outcomes. Our motivating empirical study is an evaluation of a hospital pay-for-performance scheme in England, the best practice tariffs programme. The conclusions of the original DiD analysis are sensitive to the choice of approach. We conduct a Monte Carlo simulation study that investigates these methods’ performance. While DiD produces unbiased estimates when the parallel trends assumption holds, the alternative approaches provide less biased estimates of treatment effects when it is violated. In these cases, the LDV approach produces the most efficient and least biased estimates

Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma

Background: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of objective response and overall survival. The impact on healthcare costs had been studied in small series based on a hypothetical model and was in favor of DEB-TACE. We aimed to evaluate and compare healthcare costs and effectiveness of both modalities in a cohort of patients from Nottingham, UK. Methods: Using a dedicated radiology database, we identified all patients who had undergone cTACE or DEB-TACE between 2006 and 2012 at a single tertiary referral center based in Nottingham. We collected clinical data, including treatment response, postprocedure complications and 30-day mortality. Costing models were constructed to present both our local hospital perspective as well as the national health service position. Results: During our study period, 101 procedures were performed on 43 patients (76 cTACE procedures on 26 patients and 25 DEB-TACE procedures on 17 patients). Overall, 11/26 in cTACE and 5/17 in DEB-TACE group had progressive disease (p=0.52). Adverse events were seen in 6/76 cTACE compared with 7/25 DEB-TACE group (p=0.16). Based on the predetermined standard pathway there was an unadjusted average cost difference of £3770.30 (TACE =£9070.44, DEB-TACE =£5300.14) in favor of the DEB-TACE. Results from our costing models indicated a £2715.33 (95% CI £580.88–4849.77) cost difference in favor of the same procedure. Conclusions: Even when the extra costs of DEB-TACE were considered, the overall treatment costs per patient were lower in relation to cTACE

Beyond Peak, a Simple Approach to Assess Rowing Power and the Impact of Training: A Technical Report

International Journal of Exercise Science 12(6): 233-244, 2019. Recently, rowing power has been shown to be a key determinant of rowing performance. However, rowing power testing can vary greatly, and is not standardized. Here we sought to evaluate rowing power over a 15 sec rowing test utilizing a stroke-by-stroke analysis before and after 4 weeks of training in youth rowers. Methods: 18 adolescent male rowers were assigned to complete either 4 weeks of plyometric training (PLYO, n=9), or steady state cycling (Control, n=9), for 30 minutes before on water training three days/week. Each group was matched for training volume. Peak power (PP) was assessed via a 15 sec maximal rowing ergometer test. Using the Ergdata mobile app, PP, peak force (PF), average force (AF), drive speed (DS), and stroke at which PP was achieved (PPstroke) were measured and recorded for later offline analysis. Results: Before training PP, PF, AF and DS did not differ between groups. After training, PP trended towards a significant difference between groups PLYO and CON (569±75 v. 629±51 Watts, control v. PLYO, p=0.08). Stroke-by-stroke analysis indicated more power was produced over the test following training (p\u3c0.05), but no group differences existed. There was also a trend towards PLYO achieving PP earlier in the test (7.7±0.9 to 6.9±0.9 strokes, p=0.08). Finally, DS during the test was significantly increased for PLYO after training (p\u3c0.05). Conclusion: This novel method of evaluating rowing power was able to detect changes in rowing power indices, providing coaches with a cost effective method of evaluating responses to rowing training

The Effect of Concurrent Plyometric Training Versus Submaximal Aerobic Cycling on Rowing Economy, Peak Power, and Performance in Male High School Rowers

BACKGROUND: Plyometric training has been shown to increase muscle power, running economy, and performance in athletes. Despite its use by rowing coaches, it is unknown whether plyometrics might improve rowing economy or performance. The purpose was to determine if plyometric training, in conjunction with training on the water, would lead to improved rowing economy and performance. METHODS: Eighteen male high school rowers were assigned to perform 4 weeks of either plyometric training (PLYO, n = 9) or steady-state cycling below ventilatory threshold (endurance, E, n = 9), for 30 min prior to practice on the water (matched for training volume) 3 days per week. Rowing performance was assessed through a 500-m rowing time trial (TT) and peak rowing power (RP), while rowing economy (RE) was assessed by measuring the oxygen cost over four work rates (90, 120, 150, and 180 W). RESULTS: Rowing economy was improved in both PLYO and E (p \u3c 0.05). The 500-m TT performance improved significantly for PLYO (from 99.8 ± 9 s to 94.6 ± 2 s, p \u3c 0.05) but not for E (from 98.8 ± 6 s to 98.7 ± 5 s, p \u3e 0.05). Finally, RP was moderately higher in the PLYO group post-training (E 569 ± 75 W, PLYO 629 ± 51 W, ES = 0.66) CONCLUSIONS: In a season when the athletes performed no rowing sprint training, 4 weeks of plyometric training improved the 500-m rowing performance and moderately improved peak power. This increase in performance may have been mediated by moderate improvements in rowing power, but not economy, and warrants further investigation

Novel liquid crystalline organic semiconducting oligomers incorporating N-heterocyclic carbazole moieties for fluorescent OLEDs

A novel class of nematic liquid crystalline organic semiconducting oligomers incorporating N-heterocyclic carbazole moieties has been synthesised using simple and highly efficient reaction pathways. The electroluminescent colour of these novel oligomers can be varied in a controlled manner by molecular design. The values of the ionization potential and the electron affinity of these electroluminescent oligomers can also be matched by structural design to the HOMO energy level of the electron-blocking layer and the LUMO energy level of electron-transporting layer in the OLEDs to create low charge-injection barriers for electrons and holes, respectively leading to electroluminescence with an efficacy up to 4.1 cd A-1

Carbon monoxide poisoning: Novel magnetic resonance imaging pattern in the acute setting

The presentation of carbon monoxide (CO) poisoning is non-specific and highly variable. The diagnosis is made when a compatible history and examination occur in a patient with elevated carboxyhaemoglobin levels. The severity of intoxication is difficult to assess accurately based on laboratory markers alone. Magnetic resonance imaging (MRI) has been shown to have superior sensitivity to computed tomography for the detection of abnormalities post CO poisoning. We report a novel imaging pattern on MRI undertaken in the acute setting in a patient with CO intoxication. We also discuss the management and follow up of patients with CO poisoning

The Long-Term Impacts of an Integrated Care Programme on Hospital Utilisation among Older Adults in the South of England: A Synthetic Control Study

Introduction: Reducing hospital use is often viewed as a possible positive consequence of introducing integrated care (IC). We investigated the impact of an IC programme in North East Hampshire and Farnham (NEHF), in southern England, on hospital utilisation among older adults over a 55 months period. Method: We used a Generalised Synthetic Control design to investigate the effect of implementing IC in NEHF between 2015 and 2020. For a range of hospital use outcomes, we estimated the trajectory that each would have followed in the absence of IC and compared it with the actual trajectory to estimate the potential impact of IC. Results: Three years into the programme, emergency admission rates started reducing in NEHF relative to its synthetic control, particularly those resulting in overnight hospital stays. By year 5 of the study overall emergency admission rates were 9.8% lower (95% confidence interval: –17.2% to –0.6%). We found no sustained difference in rates of emergency department (ED) visits, and average length of hospital stay was significantly higher from year 2. Conclusion: An IC programme in NEHF led to lower than estimated emergency admission rates; however, the interpretation of the impact of IC on admissions is complicated as lower rates did not appear until three years into the programme and the reliability of the synthetic control weakens over a long time horizon. There was no sustained change in ED visit rates