Modeling the Martian dust cycle 2. Multiannual radiatively active dust transport simulations

Multiannual dust transport simulations have been performed using a Mars general circulation model containing a dust transport scheme which responds to changes in the atmospheric state. If the dust transport is 'radiatively active,� the atmospheric state also responds to changes in the dust distribution. This paper examines the suspended dust distribution obtained using different lifting parameterizations, including an analysis of dust storms produced spontaneously during these simulations. The lifting mechanisms selected are lifting by (1) near-surface wind stress and (2) convective vortices known as dust devils. Each mechanism is separated into two types of parameterization: threshold-sensitive and -insensitive. The latter produce largely unrealistic annual dust cycles and storms, and no significant interannual variability. The threshold-sensitive parameterizations produce more realistic annual and interannual behavior, as well as storms with similarities to observed events, thus providing insight into how real Martian dust storms may develop. Simulations for which dust devil lifting dominates are too dusty during northern summer. This suggests either that a removal mechanism (such as dust scavenging by water ice) reduces opacities at this time or that dust devils are not the primary mechanism for storm production. Simulations for which near-surface wind stress lifting dominates produce the observed low opacities during northern spring/summer, yet appear unable to produce realistic global storms without storm decay being prevented by the occurrence of large-scale positive feedbacks on further lifting. Simulated dust levels are generally linked closely to the seasonal state of the atmosphere, and no simulation produces the observed amount of interannual variability

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. However, reactive aldehydes, when added to tumor cells, can exert an anticancerous effect. They act, analogously to other chemotherapeutic drugs, by forming DNA adducts and, in this way, they drive the tumor cells toward apoptosis. The aldehyde-DNA adducts, which can be observed during inflammation, play an important role by inducing epigenetic changes which, in turn, can modulate the inflammatory process. The pathogenic role of the adducts formed by the products of LPO with biological macromolecules in the breaking of immunological tolerance to self antigens and in the development of autoimmunity has been supported by a wealth of evidence. The instrumental role of the adducts of reactive LPO products with self protein antigens in the sensitization of autoreactive cells to the respective unmodified proteins and in the intermolecular spreading of the autoimmune responses to aldehyde-modified and native DNA is well documented. In contrast, further investigation is required in order to establish whether the formation of adducts of LPO products with DNA might incite substantial immune responsivity and might be instrumental for the spreading of the immunological responses from aldehyde-modified DNA to native DNA and similarly modified, unmodified and/or structurally analogous self protein antigens, thus leading to autoimmunity

Liberalismo internacional e justiça distributiva International liberalism and distributive justice

Três enfoques de justiça distributiva internacional (que exprimem diferentes pressupostos da tradição liberal) representadas na literatura recente são descritos. Examina-se o tema com relação à questão dos direitos humanos.<br>Three approaches to international distributive justice (which express distinct assumptions of the liberal tradition) represented in recent literature are described. The theme is examined with regard to the question of human rights

Aurora A Phosphorylates MCAK to Control Ran-dependent Spindle Bipolarity

During mitosis, mitotic centromere-associated kinesin (MCAK) localizes to chromatin/kinetochores, a cytoplasmic pool, and spindle poles. Its localization and activity in the chromatin region are regulated by Aurora B kinase; however, how the cytoplasmic- and pole-localized MCAK are regulated is currently not clear. In this study, we used Xenopus egg extracts to form spindles in the absence of chromatin and centrosomes and found that MCAK localization and activity are tightly regulated by Aurora A. This regulation is important to focus microtubules at aster centers and to facilitate the transition from asters to bipolar spindles. In particular, we found that MCAK colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing. In addition, we found that MCAK localization at spindle poles was regulated through another Aurora A phosphorylation site (S719), which positively enhances bipolar spindle formation. This is the first study that clearly defines a role for MCAK at the spindle poles as well as identifies another key Aurora A substrate that contributes to spindle bipolarity