24 research outputs found
Responses of soil nitrogen-fixing, ammonia-oxidizing, and denitrifying bacterial communities to long-term chlorimuron-ethyl stress in a continuously cropped soybean field in Northeast China
Toward a General Theory of Boundary Work: Insights from the CGIAR's Natural Resource Management Programs
Method, Scale and Socio-Technical Networks: Problems of Standardization in Acid Rain, Ozone Depletion and Global Warming Research
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Global Civil Society and Global Environmental Governance: The Politics of Nature from Place to Planet. Ronnie D. Lipschutz (with Judith Mayer). Albany, NY:State University of New York Press,1996, 365 pp. US18.95 paper. ISBN 0-7914-3118-5. State University of New York Press, State University Plaza, Albany, NY 12246-0001, USA.
Ozone Discourses: Science and Politics in Global Environmental Cooperation. Karen T. Litfin New York:Columbia University Press,1994, 257 pp. US16.50 paper. ISBN 0-231-08137-5. Columbia University Press, 562 W. 113th St., New York, NY 10011, USA.
Fast and accurate genome-wide predictions and structural modeling of protein–protein interactions using Galaxy
Abstract Background Protein–protein interactions play a crucial role in almost all cellular processes. Identifying interacting proteins reveals insight into living organisms and yields novel drug targets for disease treatment. Here, we present a publicly available, automated pipeline to predict genome-wide protein–protein interactions and produce high-quality multimeric structural models. Results Application of our method to the Human and Yeast genomes yield protein–protein interaction networks similar in quality to common experimental methods. We identified and modeled Human proteins likely to interact with the papain-like protease of SARS-CoV2’s non-structural protein 3. We also produced models of SARS-CoV2’s spike protein (S) interacting with myelin-oligodendrocyte glycoprotein receptor and dipeptidyl peptidase-4. Conclusions The presented method is capable of confidently identifying interactions while providing high-quality multimeric structural models for experimental validation. The interactome modeling pipeline is available at usegalaxy.org and usegalaxy.eu