Evolution of Endoscopic Lesions in Steroid-Refractory Acute Severe Ulcerative Colitis Responding to Infliximab or Cyclosporine

BACKGROUND/AIMS: Few data on the evolution of endoscopic findings are available in patients with acute severe ulcerative colitis (ASUC). The aim of this study was to describe this evolution in a prospective cohort. METHODS: Patients admitted for a steroid-refractory ASUC and included in a randomized trial comparing infliximab and cyclosporine were eligible if they achieved steroid-free clinical remission at day 98. Flexible sigmoidoscopies were performed at baseline, days 7, 42 and 98. Ulcerative colitis endoscopic index of severity (UCEIS) and its sub-scores - vascular pattern, bleeding and ulceration/erosion - were post-hoc calculated. Global endoscopic remission was defined by a UCEIS of 0, and partial endoscopic remission by any UCEIS sub-score of 0. RESULTS: Among the 55 patients analyzed (29 infliximab and 26 cyclosporine), 49 (83%) had UCEIS >= 6 at baseline at baseline. Partial endoscopic remission rates were higher for bleeding than for vascular pattern and for ulcerations/erosions at day 7 (20% vs. 4% and 5% (n = 55); p CONCLUSION: In steroid-refractory ASUC patients responding to a second-line medical therapy, endoscopic remission process started with bleeding remission and was not achieved in half the patients at day 98 for vascular pattern. Infliximab provided a higher endoscopic remission rate than cyclosporine at day 98.Peer reviewe

Devenir à long terme et facteurs prédictifs de récidive de l anémie dans une cohorte de 102 patients agés de plus de 75 ans, explorés pour une anémie ferriprive

PARIS13-BU Serge Lebovici (930082101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Prise en charge et facteurs prédictifs de mortalité à court terme des patients agés de plus de 75 ans ayant une anémie ferriprive (Etude prospective de 111 patients)

PARIS13-BU Serge Lebovici (930082101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

RESULTS FROM VUV SPECTROSCOPY OF NEUTRAL DIAMONDOID MOLECULES AND IR SPECTROSCOPY OF THE CATIONIC SPECIES

Saslaw and Gaustad, Nature, \textbf{221Lewis et al., Nature, \textbf{326van Kerckhoven et al., Astronomy and Astrophysic, \textbf{384Pirali et al., The Astrophysical Journal, \textbf{661Author Institution: Laboratoire de Photophysique Moleculaire, Universite Paris-Sud, 91405 Orsay Cedex, France; FOM-Institute for Plasma Physics Rijnhuizen, NL 3430 BE Nieuwegein, The Netherlands; Synchrotron SOLEIL, L'Orme des Merisiers Saint-Aubin, 91192 Gif-sur-Yvette, FranceDue to their stability, diamond materials are expected to be present in different environments of the interstellar medium, 160 (1969)}. Indeed, nanometer size diamond cristals have been extracted from carbonaceous chondrites, 160 (1987)} and two emission features (observed at 3.43 $\mu$m and 3.53 $\mu$m) in the spectra of HD 97048 and Elias1 have been assigned to these species, 568 (2002)}. Despite this high astrophysical relevance, very few is known about the structural properties and dynamics of the molecular building blocks of larger species : the diamondoid molecules. These molecules consist of sp3 hybridized carbon cages where dangling bonds are terminated by hydrogen atoms. The infrared spectra of neutral molecules conforted the assignment of the 3.43 $\mu$m and 3.53 $\mu$m emission features to nanometer size diamondoid systems, 919 (2007)}. In order to improve the understanding of the possible process leading to the IR emission features, we recorded the IR spectra of the deshydrogenated cationic species of adamantane, diamantane and triamantane (using Infrared Multi Photon Dissociation technique with the free electron laser FELIX) as well as the VUV spectra of adamantane and diamantane (obtained thanks to the Threshold Photo Electron Photo Ion Coincidence technique at the DESIRS beamline of the synchrotron SOLEIL). We will show the results of these spectra and the preliminary analysis