TBVAC2020 : advancing tuberculosis vaccines from discovery to clinical development

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal

TBVAC2020: Advancing tuberculosis vaccines from discovery to clinical development

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal

¿NOMADAS Y SEDENTARIOS?

¿El científico, la ciencia, podrían soportar el violento dualismo impuesto por la división entre ciencias sociales y naturales, o duras y blandas ? Lo que cada dominio científico experimenta es, paradójicamente, que, como bloques desigualmente formados y de densidad variable según cada caso, sobrenadan en una sopa noológica. Estos bloques cubren completamente la sopa, pero la llenan de manera heterogénea y variable, por acoplamientos desiguales y chirriantes, con superposiciones y contagios que hacen que las zonas de vecindad permanezcan en un estado de indeterminación real... tal vez esta zona de vecindad es la que habita el concepto nómada, la que mide sin agotar -se diría que número de modo continuo- la función nómada. Isabelle Stenger descubre esta zona como una zona de agitación, de relación irreductible con el afuera, y la retoma en su giro ético como ecología de las prácticas ... quisiéramos decirle al lector y en primer lugar a nosotros mismos: ¡Leedla!

¿Nómadas y sedentarios?

¿El científico, la ciencia, podrían soportar el violento dualismo impuesto por la división entre ciencias sociales y naturales, o “duras” y “blandas”? Lo que cada dominio “científico” experimenta es, paradójicamente, que, como bloques desigualmente formados y de densidad variable según cada caso, sobrenadan en una sopa noológica. Estos bloques cubren completamente la sopa, pero la llenan de manera heterogénea y variable, por acoplamientos desiguales y chirriantes, con superposiciones y contagios que hacen que las zonas de vecindad permanezcan en un estado de indeterminación real... tal vez esta zona de vecindad es la que habita el concepto nómada, la que mide sin agotar “se diría que número de modo continuo” la función nómada. Isabelle Stenger descubre esta zona como una zona de agitación, de relación irreductible con el afuera, y la retoma en su giro ético como “ecología de las prácticas”... quisiéramos decirle al lector y en primer lugar a nosotros mismos: ¡Leedla

Plano comunicacional 44oito

Orientadora: Profa. Dra. Valquíria JohnMonografia (graduação) - Universidade Federal do Paraná, Setor de Artes, Comunicação e Design, Curso de Graduação em Publicidade e PropagandaInclui referênciasResumo : Durante o período da pandemia da Covid-19, foi possível notar um espaço de oportunidades para novas ferramentas e plataformas que trabalham com a ideia de levar a diversão ao cliente. O presente trabalho foi realizado com a proposta de estruturar a campanha de lançamento do novo empreendimento da rede de bares 44oito, localizada em São Paulo. A marca investiu em um empório que funciona em modelo de canal de delivery, Empório Express. Em um primeiro momento, realizou-se uma análise de mercado, utilizando como referência o caso do aplicativo Zé Delivery, junto a uma pesquisa quanti-quali via formulário online, ambos momentos buscando entender o público-alvo da marca e se seria viável o lançamento do Empório Express. Assim, como metodologia foram utilizadas pesquisa bibliográfica e análise de conteúdo. A partir dos resultados obtidos na pesquisa, foi possível concluir que existe demanda e mercado para o empreendimento. Logo, o objetivo da campanha de lançamento foi associar a marca a todo momento de diversão e confraternização, em um espaço que transcende a sede física do bar e invade as casas dos consumidores, com uma comunicação informal e acessível, para tornar o 44oito Express parte do grupo de amigos, uma presença indispensável na festa. Para isso a proposta lançamento se dividiu em três momentos: Identidade visual para 44oito Express, divulgação de um evento de kart promovida pela marca e, por fim, uma inauguração do local com a temática "esquent

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

International audienc

Diffusion of a collaborative care model in primary care: a longitudinal qualitative study

<p>Background</p> <p>Although collaborative team models (CTM) improve care processes and health outcomes, their diffusion poses challenges related to difficulties in securing their adoption by primary care clinicians (PCPs). The objectives of this study are to understand: (1) how the perceived characteristics of a CTM influenced clinicians' decision to adopt -or not- the model; and (2) the model's diffusion process.</p> <p>Methods</p> <p>We conducted a longitudinal case study based on the Diffusion of Innovations Theory. First, diffusion curves were developed for all 175 PCPs and 59 nurses practicing in one borough of Paris. Second, semi-structured interviews were conducted with a representative sample of 40 PCPs and 15 nurses to better understand the implementation dynamics.</p> <p>Results</p> <p>Diffusion curves showed that 3.5 years after the start of the implementation, 100% of nurses and over 80% of PCPs had adopted the CTM. The dynamics of the CTM's diffusion were different between the PCPs and the nurses. The slopes of the two curves are also distinctly different. Among the nurses, the <it>critical mass</it> of adopters was attained faster, since they adopted the CTM earlier and more quickly than the PCPs. Results of the semi-structured interviews showed that these differences in diffusion dynamics were mostly founded in differences between the PCPs' and the nurses' perceptions of the CTM's <it>compatibility</it> with norms, values and practices and its <it>relative advantage</it> (impact on patient management and work practices). Opinion leaders played a key role in the diffusion of the CTM among PCPs.</p> <p>Conclusion</p> <p>CTM diffusion is a social phenomenon that requires a major commitment by clinicians and a willingness to take risks; the role of opinion leaders is key. Paying attention to the notion of a <it>critical mass</it> of adopters is essential to developing implementation strategies that will accelerate the adoption process by clinicians.</p

Prime-Boost Vaccination with rBCG/rAd35 Enhances CD8+ Cytolytic T-Cell Responses in Lesions from Mycobacterium Tuberculosis –Infected Primates

To prevent the global spread of tuberculosis (TB) infection, a novel vaccine that triggers potent and long-lived immunity is urgently required. A plasmid-based vaccine has been developed to enhance activation of major histocompatibility complex (MHC) class I–restricted CD8+ cytolytic T cells using a recombinant Bacille Calmette-Guérin (rBCG) expressing a pore-forming toxin and the Mycobacterium tuberculosis (Mtb) antigens Ag85A, 85B and TB10.4 followed by a booster with a nonreplicating adenovirus 35 (rAd35) vaccine vector encoding the same Mtb antigens. Here, the capacity of the rBCG/rAd35 vaccine to induce protective and biologically relevant CD8+ T-cell responses in a nonhuman primate model of TB was investigated. After prime/boost immunizations and challenge with virulent Mtb in rhesus macaques, quantification of immune responses at the single-cell level in cryopreserved tissue specimen from infected organs was performed using in situ computerized image analysis as a technological platform. Significantly elevated levels of CD3+ and CD8+ T cells as well as cells expressing interleukin (IL)-7, perforin and granulysin were found in TB lung lesions and spleen from rBCG/rAd35-vaccinated animals compared with BCG/rAd35-vaccinated or unvaccinated animals. The local increase in CD8+ cytolytic T cells correlated with reduced expression of the Mtb antigen MPT64 and also with prolonged survival after the challenge. Our observations suggest that a protective immune response in rBCG/rAd35-vaccinated nonhuman primates was associated with enhanced MHC class I antigen presentation and activation of CD8+ effector T-cell responses at the local site of infection in Mtb-challenged animals