A Blockchain, 5G and IoT-based transaction management system for Smart Logistics: an Hyperledger framework

The recent technological progress has started a revolution in the logistic and supply chain environment, known as Logistics 4.0. Such a revolution is strongly based on information sharing and digitalization. For this reason, distributed ledger technologies (and blockchain in particular) are attracting the interest of countries and companies. However, the proper verification of data coming from oracles is a huge issue. This paper proposes a solution integrating Blockchain and IoT, by exploiting the enhanced data security and integrity provided by Narrowband-IoT. A preliminary performance evaluation of Hyperledger Fabric and Hyperladger Sawtooth is also presented

UAVs and UAV Swarms for Civilian Applications: Communications and Image Processing in the SCIADRO Project

The use of unmanned aerial systems is increasingly common in both research and industrial fields. Nowadays, the use of single unmanned aerial vehicles is quite established and several products are already available to consumers, while swarms are still subject of research and development. This work describes the objectives of a research project, namely SCIADRO, which deals with innovative applications and network architectures based on the use of single unmanned aerial vehicles and of swarms in several civilian fields

Autosomal-dominant transthyretin (TTR)-related amyloidosis is not a frequent CMT2 neuropathy “in disguise”

Abstract Transthyretin (TTR)-related familial amyloid polyneuropathy (TTR-FAP) is a life-threatening autosomal dominant, systemic disease. First symptoms usually occur from the second to over sixth decade of life with a length-dependent axonal neuropathy with prominent involvement of the small fibers and multi-organ systemic failure. Early diagnosis is pivotal for effective therapeutic options, but it is hampered by the heterogeneity of the clinical spectrum which can lead to misdiagnosis with other neurological condition/disorder such as axonal sensory-motor neuropathy (CMT2) as described in literature. The aim of our study was to search for TTR mutations in a large cohort of selected undiagnosed axonal sensory-motor neuropathy patients to establish if misdiagnosis is frequent or rare in the Italian population. No TTR pathogenic variants were found in our cohort. In conclusion, our study shows that TTR testing not should be straightforward recommended in CMT2 patients but only when “red flags” TTR’s features are present

Huntington's disease: from experimental results to interaction networks, patho-pathway construction and disease hypothesis

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Wireless Sensor Networks: A Survey on the State of the Art and the 802.15.4 and Zigbee Standards

NoWireless sensor networks are an emerging technology for low-cost, unattended monitoring of a wide range of environments. Their importance has been enforced by the recent delivery of the IEEE 802.15.4 standard for the physical and MAC layers and the forthcoming ZigBee standard for the network and application layers. The fast progress of research on energy efficiency, networking, data management and security in wireless sensor networks, and the need to compare with the solutions adopted in the standards motivates the need for a survey on this field

Network integration and modelling of dynamic drug responses at multi-omics levels

Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized by integrating the molecular activities in networks of interacting proteins. As proof-of-concept we challenge network modeling with time-resolved proteome, transcriptome and methylome measurements in iPSC-derived human 3D cardiac microtissues to elucidate adverse mechanisms of anthracycline cardiotoxicity measured with four different drugs (doxorubicin, epirubicin, idarubicin and daunorubicin). Dynamic molecular analysis at in vivo drug exposure levels reveal a network of 175 disease-associated proteins and identify common modules of anthracycline cardiotoxicity in vitro, related to mitochondrial and sarcomere function as well as remodeling of extracellular matrix. These in vitro-identified modules are transferable and are evaluated with biopsies of cardiomyopathy patients. This to our knowledge most comprehensive study on anthracycline cardiotoxicity demonstrates a reproducible workflow for molecular medicine and serves as a template for detecting adverse drug responses from complex omics data