Pseudomembranous Trigonitis: A Common but Underrecognized Urological Entity

Pseudomembranous trigonitis is the term used to describe squamous metaplastic changes of the bladder trigone, which affect nearly 40% of adult females. We present the characteristics of this underrecognized clinical entity and encourage further relevant research

Successful Treatment of Postoperative External Biliary Fistula by Selective Nasobiliary Drainage

A 25-year old man presented with a high output external biliary fistula after an operation for a giant hydatid cyst of the liver. Endoscopic sphincterotomy was inadequate to close the fistula. A nasobiliary tube was selectively inserted into the leaking hepatic duct and bile was continuously aspirated. The fistula and the residual cavity healed completely. Details of the patients' management using this alternative technique, are discussed

Impact of Orthodontic Forces on Plasma Levels of Markers of Bone Turnover and Inflammation in a Rat Model of Buccal Expansion.

Plasma levels of protein analytes might be markers to predict and monitor the kinetics of bone and tissue remodeling, including maximization of orthodontic treatment stability. They could help predict/prevent and/or diagnose possible adverse effects such as bone dehiscences, gingival recession, or root resorption. The objective of this study was to measure plasma levels of markers of bone turnover and inflammation during orthodontic force application in a rat model of orthodontic expansion. Two different orthodontic forces for bilateral buccal expansion of the maxillary arches around second and third molars were applied in 10 rats equally distributed in low-force (LF) or conventional force (CF) groups. Four rats served as the control group. Blood samples were collected at days 0, 1, 2, 3, 6, 13, 21, and 58. Longitudinal concentrations of osteoprotegerin (OPG), soluble receptor activator of nuclear factor kappaB ligand (sRANKL), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor α (TNF), and parathyroid hormone (PTH) were determined in blood samples by a multiplex immunoassay. CF and LF resulted in a significantly maxillary skeletal expansion while the CF group demonstrated significantly higher expansion than the LF group in the long term. Bone turnover demonstrated a two-phase response. During the "early phase" (up to 6 days of force application), LF resulted in more sRANKL expression and increased sRANKL/OPG ratio than the CF and control animals. There was a parallel increase in PTH levels in the early phase in response to LF. During the "late phase" (6-58 days), the markers of bone turnover were stable in both groups. IL-4, IL-6, and IL-10 levels did not significantly change the test groups throughout the study. These results suggest that maxillary expansion in response to different orthodontic forces follows different phases of bone turnover that may be force specific

Children’s right to participate in early childhood care and education settings and relative innovatory supportive digital tools for ECCE professionals’ development

Young children’s participation is key to developing a culture of human rights, democracy, and rule of law and according to Council of Europe (2017) and United Nations (2005). In these terms, children’s right to participate is described as a key aspect in the framework of educational quality, and the positive relationship between children’s right to participate and early childhood care and education (ECCE) quality is already documented. Although this concept is not new to ECCE professionals, its application seems to remain a challenge within everyday activities. It is thus important for ECCE professionals to reflect on this right and on the practices towards its promotion, in order to be able to supply high quality education. The paper presents the innovatory attempts regarding the digital tools developed within the PARTICIPA Erasmus+ project (Professional development tools supporting participation rights in early childhood education) aiming to involve three target group -directors, teachers and teachers’ assistants- working in all types of early childhood care and education settings, so that have a digital space to reflect about children’s right to participate and its implementation. More specifically, the paper presents (a) a training program targeting the ECCE settings’ professionals provided through a massive open online course (MOOC) in 5 languages and disseminated in an online learning platform, focusing on the theoretical and practical aspects of children’s right to participate (i.e., state of the art, relevant pedagogical practices), (b) toolkits (i.e., validated self-assessment questionnaires) for ECCE directors and teachers and teacher assistants supported by discrete qualitative studies.info:eu-repo/semantics/publishedVersio

Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated in activated B lymphocytes by activation-induced deaminase (AID). AID is thought to make lesions in DNA by deaminating cytidine residues in single-stranded DNA exposed by RNA polymerase during transcription. Although this must occur in the nucleus, AID is found primarily in the cytoplasm. Here we show that AID is actively excluded from the nucleus by an exportin CRM1-dependent pathway. The AID nuclear export signal (NES) is found at the carboxyl terminus of AID in a region that overlaps a sequence required for CSR but not SHM. We find that AID lacking a functional NES causes more hypermutation of a nonphysiologic target gene in transfected fibroblasts. However, the NES does not impact on the rate of mutation of immunoglobulin genes in B lymphocytes, suggesting that the AID NES does not limit AID activity in these cells

Quantum Interference between Impurities: Creating Novel Many-Body States in s-wave Superconductors

We demonstrate that quantum interference of electronic waves that are scattered by multiple magnetic impurities in an s-wave superconductor gives rise to novel bound states. We predict that by varying the inter-impurity distance or the relative angle between the impurity spins, the states' quantum numbers, as well as their distinct frequency and spatial dependencies, can be altered. Finally, we show that the superconductor can be driven through multiple local crossovers in which its spin polarization, $$, changes between $=0, 1/2$ and 1.Comment: 4 pages, 4 figure