183 research outputs found
Generating realistic scaled complex networks
Research on generative models is a central project in the emerging field of
network science, and it studies how statistical patterns found in real networks
could be generated by formal rules. Output from these generative models is then
the basis for designing and evaluating computational methods on networks, and
for verification and simulation studies. During the last two decades, a variety
of models has been proposed with an ultimate goal of achieving comprehensive
realism for the generated networks. In this study, we (a) introduce a new
generator, termed ReCoN; (b) explore how ReCoN and some existing models can be
fitted to an original network to produce a structurally similar replica, (c)
use ReCoN to produce networks much larger than the original exemplar, and
finally (d) discuss open problems and promising research directions. In a
comparative experimental study, we find that ReCoN is often superior to many
other state-of-the-art network generation methods. We argue that ReCoN is a
scalable and effective tool for modeling a given network while preserving
important properties at both micro- and macroscopic scales, and for scaling the
exemplar data by orders of magnitude in size.Comment: 26 pages, 13 figures, extended version, a preliminary version of the
paper was presented at the 5th International Workshop on Complex Networks and
their Application
FcγReceptors IIa on Cardiomyocytes and Their Potential Functional Relevance in Dilated Cardiomyopathy
ObjectivesThe purpose of this study was to investigate how cardiac autoantibodies might contribute to cardiac dysfunction in patients suffering from dilated cardiomyopathy (DCM).BackgroundIn the majority of DCM patients, it is possible to detect antibodies with negative inotropic effect on cardiomyocytes. The manner in which these antibodies impair cardiac function is poorly understood.MethodsImmunoglobulin (Ig)G was prepared from plasma of 11 DCM patients containing antibodies that induced a negative inotropic effect on cardiomyocytes. We analyzed the effects of antibodies/IgG fragments on calcium transients and on systolic cell shortening of adult rat cardiomyocytes and investigated the dependency of these effects on potential cardiomyocyte Fc receptors.ResultsIn contrast to control subjects, intact IgG from DCM patients reduced calcium transients and cell shortening of cardiomyocytes. The F(ab′)2fragments of these antibodies did not induce these effects but inhibited the functional effects of DCM-IgG of the respective patients’ IgG. These effects were also inhibited by Fc fragments of normal IgG. Reconstitution of the Fc part by incubation of cardiomyocytes with DCM-F(ab′)2fragments followed by goat-anti-human-F(ab′)-IgG again induced reduction of cell shortening and of calcium transients. In rat and human ventricular cardiomyocytes, Fcγreceptors IIa (CD32) were demonstrated by immunofluorescence.ConclusionsOur findings indicate that DCM-IgG-F(ab′)2bind to their cardiac antigen(s), but the Fc part might trigger the negative inotropic effects via the newly detected Fcγreceptor on cardiomyocytes. These results point to a novel potential mechanism for antibody-induced impairment of cardiac function in DCM patients
Controlled Stark shifts in Er-doped crystalline and amorphous waveguides for quantum state storage
We present measurements of the linear Stark effect on the I I transition in an Er-doped proton-exchanged
LiNbO crystalline waveguide and an Er-doped silicate fiber. The
measurements were made using spectral hole burning techniques at temperatures
below 4 K. We measured an effective Stark coefficient
kHz/Vcm in the crystalline waveguide and
kHz/Vcm in the silicate fiber.
These results confirm the potential of Erbium doped waveguides for quantum
state storage based on controlled reversible inhomogeneous broadening.Comment: 4 pages, 2 figures v2. typo in formula correcte
A solid state light-matter interface at the single photon level
Coherent and reversible mapping of quantum information between light and
matter is an important experimental challenge in quantum information science.
In particular, it is a decisive milestone for the implementation of quantum
networks and quantum repeaters. So far, quantum interfaces between light and
atoms have been demonstrated with atomic gases, and with single trapped atoms
in cavities. Here we demonstrate the coherent and reversible mapping of a light
field with less than one photon per pulse onto an ensemble of 10 millions atoms
naturally trapped in a solid. This is achieved by coherently absorbing the
light field in a suitably prepared solid state atomic medium. The state of the
light is mapped onto collective atomic excitations on an optical transition and
stored for a pre-programmed time up of to 1 mu s before being released in a
well defined spatio-temporal mode as a result of a collective interference. The
coherence of the process is verified by performing an interference experiment
with two stored weak pulses with a variable phase relation. Visibilities of
more than 95% are obtained, which demonstrates the high coherence of the
mapping process at the single photon level. In addition, we show experimentally
that our interface allows one to store and retrieve light fields in multiple
temporal modes. Our results represent the first observation of collective
enhancement at the single photon level in a solid and open the way to multimode
solid state quantum memories as a promising alternative to atomic gases.Comment: 5 pages, 5 figures, version submitted on June 27 200
Spectroscopic investigations of a Ti:Tm:LiNbO3 waveguide for photon-echo quantum memory
We report the fabrication and characterization of a
Ti:Tm:LiNbO optical waveguide in view of photon-echo quantum
memory applications. In particular, we investigated room- and
cryogenic-temperature properties via absorption, spectral hole burning, photon
echo, and Stark spectroscopy. We found radiative lifetimes of 82 s and 2.4
ms for the H and F levels, respectively, and a 44% branching
ratio from the H to the F level. We also measured an optical
coherence time of 1.6 s for the HH, 795 nm
wavelength transition, and investigated the limitation of spectral diffusion to
spectral hole burning. Upon application of magnetic fields of a few hundred
Gauss, we observed persistent spectral holes with lifetimes up to seconds.
Furthermore, we measured a linear Stark shift of 25 kHzcm/V. Our results
are promising for integrated, electro-optical, waveguide quantum memory for
photons.Comment: 11 pages, 14 figure
Generating realistic scaled complex networks
Research on generative models plays a central role in the emerging field of network science, studying how statistical patterns found in real networks could be generated by formal rules. Output from these generative models is then the basis for designing and evaluating computational methods on networks including verification and simulation studies. During the last two decades, a variety of models has been proposed with an ultimate goal of achieving comprehensive realism for the generated networks. In this study, we (a) introduce a new generator, termed ReCoN; (b) explore how ReCoN and some existing models can be fitted to an original network to produce a structurally similar replica, (c) use ReCoN to produce networks much larger than the original exemplar, and finally (d) discuss open problems and promising research directions. In a comparative experimental study, we find that ReCoN is often superior to many other state-of-the-art network generation methods. We argue that ReCoN is a scalable and effective tool for modeling a given network while preserving important properties at both micro- and macroscopic scales, and for scaling the exemplar data by orders of magnitude in size
Heidelberg-Studie 2000
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