The ORNL Space Biology Program Annual report, period ending 30 Jun. 1965

High energy proton irradiation on mammalian systems and effects on cataractagenesis, lifespan, and acute lethalit

Metro System of Local Government (A Survey)

Growth of many American cities into vast metropolitan communities of suburban cities, towns and villages clustered about the central city is creating complex problems of local government. Duplication of services and costs is matched by artificial compartmentalization of adjacent areas, all developing with little or no overall plan or logic.Herein, four outstanding community leaders examine the problem in terms of the situation in the Ohio area of Cuyahoga County, around the core city of Cleveland. Extracts from four speeches are set forth here, all delivered at a recent luncheon of the Cleveland-Marshall Alumni Association

One-Dimensional Directed Sandpile Models and the Area under a Brownian Curve

We derive the steady state properties of a general directed ``sandpile'' model in one dimension. Using a central limit theorem for dependent random variables we find the precise conditions for the model to belong to the universality class of the Totally Asymmetric Oslo model, thereby identifying a large universality class of directed sandpiles. We map the avalanche size to the area under a Brownian curve with an absorbing boundary at the origin, motivating us to solve this Brownian curve problem. Thus, we are able to determine the moment generating function for the avalanche-size probability in this universality class, explicitly calculating amplitudes of the leading order terms.Comment: 24 pages, 5 figure

'Selling it as a holistic health provision and not just about condoms ?' Sexual health services in school settings: current models and their relationship with sex and relationships education policy and provision

In this article we discuss the findings from a recent study of UK policy and practice in relation to sexual health services for young people, based in - or closely linked with - schools. This study formed part of a larger project, completed in 2009, which also included a systematic review of international research. The findings discussed in this paper are based on analyses of interviews with 51 service managers and questionnaire returns from 205 school nurses. Four themes are discussed. First, we found three main service permutations, in a context of very diverse and uneven implementation. Second, we identified factors within the school context that shaped and often constrained service provision; some of these also have implications for sex and relationships education (SRE). Third, we found contrasting approaches to the relationship between SRE input and sexual health provision. Fourth, we identified some specific barriers that need to be addressed in order to develop 'young people friendly' services in the school context. The relative autonomy available to school head teachers and governors can represent an obstacle to service provision - and inter-professional collaboration - in a climate where, in many schools, there is still considerable ambivalence about discussing 'sex' openly. In conclusion, we identify areas worthy of further research and development, in order to address some obstacles to sexual health service and SRE provision in schools

Hypercholesterolemia and microvascular dysfunction: interventional strategies

Hypercholesterolemia is defined as excessively high plasma cholesterol levels, and is a strong risk factor for many negative cardiovascular events. Total cholesterol levels above 200 mg/dl have repeatedly been correlated as an independent risk factor for development of peripheral vascular (PVD) and coronary artery disease (CAD), and considerable attention has been directed toward evaluating mechanisms by which hypercholesterolemia may impact vascular outcomes; these include both results of direct cholesterol lowering therapies and alternative interventions for improving vascular function. With specific relevance to the microcirculation, it has been clearly demonstrated that evolution of hypercholesterolemia is associated with endothelial cell dysfunction, a near-complete abrogation in vascular nitric oxide bioavailability, elevated oxidant stress, and the creation of a strongly pro-inflammatory condition; symptoms which can culminate in profound impairments/alterations to vascular reactivity. Effective interventional treatments can be challenging as certain genetic risk factors simply cannot be ignored. However, some hypercholesterolemia treatment options that have become widely used, including pharmaceutical therapies which can decrease circulating cholesterol by preventing either its formation in the liver or its absorption in the intestine, also have pleiotropic effects with can directly improve peripheral vascular outcomes. While physical activity is known to decrease PVD/CAD risk factors, including obesity, psychological stress, impaired glycemic control, and hypertension, this will also increase circulating levels of high density lipoprotein and improving both cardiac and vascular function. This review will provide an overview of the mechanistic consequences of the predominant pharmaceutical interventions and chronic exercise to treat hypercholesterolemia through their impacts on chronic sub-acute inflammation, oxidative stress, and microvascular structure/function relationships

Investigating diagrammatic reasoning with deep neural networks

Diagrams in mechanised reasoning systems are typically en- coded into symbolic representations that can be easily processed with rule-based expert systems. This relies on human experts to define the framework of diagram-to-symbol mapping and the set of rules to reason with the symbols. We present a new method of using Deep artificial Neu- ral Networks (DNN) to learn continuous, vector-form representations of diagrams without any human input, and entirely from datasets of dia- grammatic reasoning problems. Based on this DNN, we developed a novel reasoning system, Euler-Net, to solve syllogisms with Euler diagrams. Euler-Net takes two Euler diagrams representing the premises in a syl- logism as input, and outputs either a categorical (subset, intersection or disjoint) or diagrammatic conclusion (generating an Euler diagram rep- resenting the conclusion) to the syllogism. Euler-Net can achieve 99.5% accuracy for generating syllogism conclusion. We analyse the learned representations of the diagrams, and show that meaningful information can be extracted from such neural representations. We propose that our framework can be applied to other types of diagrams, especially the ones we don’t know how to formalise symbolically. Furthermore, we propose to investigate the relation between our artificial DNN and human neural circuitry when performing diagrammatic reasoning

The Pricing of Market-to-Market Contingent Claims in a No-Arbitrage Economy

This paper assumes that the underlying asset prices are lognormally distributed and drives necessary and sufficient conditions for the valuation of options using a Black-Scholes type methodology. It is shown that the price of a futures-style, market-to-market option is given by Black’s formula if the pricing kernel is lognormally distributed. Assuming that this condition is fulfilled, it is then shown that the Black-Scholes formula prices a spot-settled contingent claim, if the interest-rate accumulation factor is lognormally distributed. Otherwise, the Black-Scholes formula holds if the product of the pricing kernel and the interest-rate accumulation factor is lognormally distributed

Cohesion, team mental models, and collective efficacy: Towards an integrated framework of team dynamics in sport

A nomological network on team dynamics in sports consisting of a multi-framework perspective is introduced and tested. The aim was to explore the interrelationship among cohesion, team mental models (TMM), collective-efficacy (CE), and perceived performance potential (PPP). Three hundred and forty college-aged soccer players representing 17 different teams (8 female and 9 male) participated in the study. They responded to surveys on team cohesion, TMM, CE and PPP. Results are congruent with the theoretical conceptualization of a parsimonious view of team dynamics in sports. Specifically, cohesion was found to be an exogenous variable predicting both TMM and CE beliefs. TMM and CE were correlated and predicted PPP, which in turn accounted for 59% of the variance of objective performance scores as measured by teams’ season record. From a theoretical standpoint, findings resulted in a parsimonious view of team dynamics, which may represent an initial step towards clarifying the epistemological roots and nomological network of various team-level properties. From an applied standpoint, results suggest that team expertise starts with the establishment of team cohesion. Following the establishment of cohesiveness, teammates are able to advance team-related schemas and a collective sense of confidence. Limitations and key directions for future research are outlined

Universal law of fractionation for slightly polydisperse systems

By perturbing about a general monodisperse system, we provide a complete description of two-phase equilibria in any system which is slightly polydisperse in some property (e.g., particle size, charge, etc.). We derive a universal law of fractionation which is corroborated by comprehensive experiments on a model colloid-polymer mixture. We furthermore predict that phase separation is an effective method of reducing polydispersity only for systems with a skewed distribution of the polydisperse property