Paracoccidioidomycosis 40 years after renal transplantation: a case-report: Paracoccidioidomicose 40 anos após transplante renal: um relato de caso

Paracoccidioidomycosis is a systemic mycotic disease caused by termic-dimorphic fungi from the Paracoccidioides sp complex, which are endemic in Brazil and over 90% of cases are presented in the chronic form. It is a rare and severe infection in patients that underwent organ transplantation, according to few reported cases in literature. Our aim is to report a rare occurence of paracoccidioidomycosis in a renal transplant recipient, diagnosed over 40 years after the procedure and to draw attention to the importance of considering the diagnosis in immunosuppressed patients from endemic areas

Post-Biopsy Complications Associated with Percutaneous Kidney Biopsy

Renal physiology and physiopathology have been the object of studies aimed at developing exams that can assist in the early diagnosis of the base disease. Chronic kidney disease consists of the progressive, irreversible loss of kidney function. Early detection and appropriate treatment can minimize the progression of the disease, lower the inherent costs, and improve the quality of life of affected individuals. Kidney biopsy is the key method in this evaluation, as it enables the histological and immunohistochemical analysis of specimens in a fast, safe, and economical manner. The main indications for kidney biopsy are nephrotic syndrome, acute kidney failure of unknown etiology, persistent hematuria and proteinuria, chronic kidney disease with conserved kidney dimensions, and transplanted kidneys (to evaluate stages of rejection, infection, and/or sclerosis). However, as an invasive method, kidney biopsy is not without complications. Post-biopsy complication rates range from 5 to 15%, with 6.6% considered minor (macrohematuria with no need for blood transfusion) and another 7.7% considered major (hemorrhage requiring blood transfusion or other approaches). In this chapter, we address the main aspects of kidney biopsy, the technical procedures for its execution, and the management of the main complications stemming from this procedure

Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine: A Behavioral and Electrophysiological Approach

We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management

Epidemiological aspects and oral implications of Paracoccidioidomycosis infection: an integrative review

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis. It represents a significant infection in South America, occurring mainly in tropical and subtropical countries such as Brazil. Oral mucosal lesions, which are the most important symptom in dentistry, may be the first visible physical manifestation of the disease, often preceding even pulmonary lesions. This study aims to carry out an integrative literature review to identify the main epidemiological aspects and oral implications of Paracoccidioidomycosis (PMC) infection. A search was carried out in the PubMed, LILACS and SciELO databases and, after applying the inclusion, exclusion, eligibility and thematic relevance criteria, 18 articles were selected for analysis in this study. Paracoccidioidomycosis (PCM) is endemic in Brazil and mainly affects middle-aged and elderly men and occurs in rural areas. It is a systemic disease where clinical manifestations are often added to oral lesions. Dentists play a key role in identifying these lesions, in the correct diagnosis and treatment of this disease. Making PCM notification compulsory in Brazil is essential.Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis. It represents a significant infection in South America, occurring mainly in tropical and subtropical countries such as Brazil. Oral mucosal lesions, which are the most important symptom in dentistry, may be the first visible physical manifestation of the disease, often preceding even pulmonary lesions. This study aims to carry out an integrative literature review to identify the main epidemiological aspects and oral implications of Paracoccidioidomycosis (PMC) infection. A search was carried out in the PubMed, LILACS and SciELO databases and, after applying the inclusion, exclusion, eligibility and thematic relevance criteria, 18 articles were selected for analysis in this study. Paracoccidioidomycosis (PCM) is endemic in Brazil and mainly affects middle-aged and elderly men and occurs in rural areas. It is a systemic disease where clinical manifestations are often added to oral lesions. Dentists play a key role in identifying these lesions, in the correct diagnosis and treatment of this disease. Making PCM notification compulsory in Brazil is essential

Jogo educativo sobre drogas para cegos: construção e avaliação

Estudo realizado com o objetivo de construir e avaliar um jogo educativo sobre drogas psicoativas acessível a pessoas cegas, desenvolvido em três etapas: construção do jogo educativo, avaliação por três especialistas em educação especial e doze cegos. Foi construído um jogo de tabuleiro denominado Drogas: jogando limpo . Na Versão Alfa os especialistas fizeram sugestões em relação às e instruções e ao tabuleiro: textura das casas, peças do jogo e escrita em Braille. Na Versão Beta, procedeu-se à avaliação pelos cegos, os quais sugeriram alterações na textura das casas e colocação de velcro para fixação do pino no tabuleiro. Passou-se, então, à Versão Gama, jogada pelas últimas três duplas de cegos e considerada adequada. Na avaliação dos juízes, o jogo revelou-se adequado, pois permite o acesso à informação sobre drogas psicoativas de maneira lúdica

Brazilian consortium for the study on renal diseases associated with COVID-19 : a multicentric effort to understand SARS-CoV-2-related nephropathy

Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Serviços Hospitalares (EBSERH) network, as well as some state hospitals and an autopsy center. All biopsies will be sent to the referral center for renal pathology of the EBSERH network. The data will include patients who had coronavirus disease, both alive and deceased, with or without pre-existing kidney disease. Kidney biopsies will be analyzed by light, fluorescence, and electron microscopy. Furthermore, immunohistochemical (IHC) staining for various inflammatory cells (i.e., cells expressing CD3, CD20, CD4, CD8, CD138, CD68, and CD57) as well as angiotensin-converting enzyme 2 (ACE2) will be performed on paraffinized tissue sections. In addition to ultrastructural assays, in situ hybridization (ISH), IHC and reverse transcription-polymerase chain reaction (RT-PCR) will be used to detect Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in renal tissue. For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping. For patients with thrombotic microangiopathy, thrombospondin type 1 motif, member 13 (ADAMTS13), antiphospholipid, and complement panel will be performed. The setting of this study is Brazil, which is second behind the United States in highest confirmed cases and deaths. With this complete approach, we hope to help define the spectrum and impact, whether immediate or long-term, of kidney injury caused by SARS-CoV-2