Analýza siete ŽP Group podľa vybraných oblastí skúmania Novej ekonomickej geografie a teórie učiacich sa regiónov.

Paper is based on theoretical knowledge of current trends in regional development – New Economic Geography and the theory of Learning regions. Paper is primary focused on a large company – located in the Banská Bystrica region – and on a network created by it and their importance for regional development. We explore processes within the Mother Company and its network that are enacted during creation of industrial network which was initiated by the Mother Company. In addition, we also explore importance of such a network for regions; knowledge and information flows within this network and their importance for regional development; innovations and investments to human capital through Mother Company and importance of these activities for region.Region. Regional development. New Economic Geography. Learning region. Network. Knowledge flows. Education. Innovations. Investments. Human capital

A Digital Repository at University Department Level

The reasons for creating a digital repository of separate department at university are discussed from the perspective of intent and initial planning. An attempt to identify the broad requirements concerning the development of a departmental repository is reported. General considerations about policies and functional requirements are outlined with respect to the institution context. Technical and system issues are briefly discussed

Development of the aircraft control devices

Tato bakalářská práce zpracovává rešeršní formou vývoj prostředků řízení letounu od konce 18. století do dnešní doby. Princip řízení letounu pomocí tří rotačních stupňů volnosti je znám od začátku 20. století, avšak jeho objevení předcházely pokusy leteckých nadšenců více než století dříve. Ovládání letounu třemi rotacemi použili poprvé bratři Wrightové a přetrvává dodnes. Konkrétní konstrukční provedení orgánů řízení je dnes voleno s ohledem na aerodynamické vlastnosti s požadavkem minimální hmotnosti a dostatečné pevnosti pro konkrétní účel letounu. Stále větší řídicí síly na řídidlech v pilotní kabině vlivem náročnějších požadavků na ovladatelnost a rychlost letu neumožňují pohodlné a nenáročné řízení. Z tohoto důvodu je třeba je ovlivňovat. V textu jsou popsány možnosti vyvážení a zmenšení těchto sil a problematika zpětné vazby zatížení kormidel letounu směrem k pilotovi. Práce poskytuje ucelený přehled vývoje principů orgánů řízení a čtenáře seznamuje s klasickými i nekonvenčními prostředky řízení letounu.This bachelor thesis handles by literature research the development of airplane control devices since end of the 18th century. The principle of airplane control using three rotational degrees of freedom is known since beginning of 20th century, but there were many attempts to find this principle more than hundred years ago. The three axis control system was used for the first time by Wright brothers and has been used since then. The particular design of the airplane control surfaces is nowadays selected with regard to aerodynamical properties with requirements of minimum weight and adequate strength. An increasing control forces on control stick and pedals in airplane cocpit due to demanding requirements to maneuverability and speed of flight do not allow pilot comfortable and easy driving. Therefore it is necessary to influence this forces. In the text there are described possibilities of influencing them such as problems of feedback from control surfaces to pilot. This thesis gives a comprehensive overview of development of airplane control principles and gives the summary of classical and unconventional airplane control devices.

Development of the aircraft control devices

Tato bakalářská práce zpracovává rešeršní formou vývoj prostředků řízení letounu od konce 18. století do dnešní doby. Princip řízení letounu pomocí tří rotačních stupňů volnosti je znám od začátku 20. století, avšak jeho objevení předcházely pokusy leteckých nadšenců více než století dříve. Ovládání letounu třemi rotacemi použili poprvé bratři Wrightové a přetrvává dodnes. Konkrétní konstrukční provedení orgánů řízení je dnes voleno s ohledem na aerodynamické vlastnosti s požadavkem minimální hmotnosti a dostatečné pevnosti pro konkrétní účel letounu. Stále větší řídicí síly na řídidlech v pilotní kabině vlivem náročnějších požadavků na ovladatelnost a rychlost letu neumožňují pohodlné a nenáročné řízení. Z tohoto důvodu je třeba je ovlivňovat. V textu jsou popsány možnosti vyvážení a zmenšení těchto sil a problematika zpětné vazby zatížení kormidel letounu směrem k pilotovi. Práce poskytuje ucelený přehled vývoje principů orgánů řízení a čtenáře seznamuje s klasickými i nekonvenčními prostředky řízení letounu.This bachelor thesis handles by literature research the development of airplane control devices since end of the 18th century. The principle of airplane control using three rotational degrees of freedom is known since beginning of 20th century, but there were many attempts to find this principle more than hundred years ago. The three axis control system was used for the first time by Wright brothers and has been used since then. The particular design of the airplane control surfaces is nowadays selected with regard to aerodynamical properties with requirements of minimum weight and adequate strength. An increasing control forces on control stick and pedals in airplane cocpit due to demanding requirements to maneuverability and speed of flight do not allow pilot comfortable and easy driving. Therefore it is necessary to influence this forces. In the text there are described possibilities of influencing them such as problems of feedback from control surfaces to pilot. This thesis gives a comprehensive overview of development of airplane control principles and gives the summary of classical and unconventional airplane control devices.

Explosion risk assessments for facilities with compressed flammable gases

In the fi rst part of the article we discuss the possibilities and analytical tools that can deal with the classifi cation of space into zones with danger of explosion for devices with the presence of compressed fl ammable gases. Then we continue with specifi cations of possibilities for practical utilization linked to variables such as ventilation degree, hypothetical volume etc., including the examples. At the end we also give a brief overview of software for modelling gas leak, including examples of an outcome

The Metaspeed project - a progress report

The outcomes of the first stage of the Metaspeed project are represented. Our team participates in the national project “Automated Metadata Extraction for e-documents Specifications and Standards” funded by the Bulgarian National Science Fund, Ministry of Education and Sciences”, contract N D002 (TK)-308/ 19.12.2008. The project aims to investigate and create technologies, methods and tools for automatic generation of metadata thus facilitating the proper specification of documents with different e-format, content and location . In the context of general description of the project outcomes we represent here the contribution of our team

Biomass local production systems and their managing – alternative to rural development in Slovakia

Local production systems (LPS) focused on biomass usage represent a viable alternative to rural development, which can contribute to solve its socio-economic problems in Slovakia. The main objective of this paper was to propose a general framework for the functioning of biomass LPS in rural areas and to summarize the main points for smooth running of biomass LPS projects aimed at the resource base, method of obtaining energy from biomass, energy production cycle and a dialogue with inhabitants of municipalities where biomass LPS are to be located. Lack of experience in implementing such projects was the root cause of problems in Banská Bystrica region. Therefore, access to information, experiences form other countries and the development of appropriate formal and informal linkages are necessary for knowledge transfer and play an important role in managing biomass LPS

Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer

Despite distant metastases being the critical factor affecting patients' survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles differ between Synchronous (SmCRC) and Metachronous (MmCRC) colorectal cancer. This characterization was performed by whole exome sequencing, whole transcriptome, whole methylome, and miRNAome. The most frequent somatic mutations were in APC, SYNE1, TP53, and TTN genes. Among the differently methylated and expressed genes were those involved in cell adhesion, extracellular matrix organization and degradation, neuroactive ligand-receptor interaction. The top up-regulated microRNAs were hsa-miR-135b-3p and -5p, and the hsa-miR-200-family while the hsa-miR-548-family belonged to the top down-regulated. MmCRC patients evinced higher tumor mutational burden, a wider median of duplications and deletions, and a heterogeneous mutational signature than SmCRC. Regarding chronicity, a significant down-regulation of SMOC2 and PPP1R9A genes in SmCRC compared to MmCRC was observed. Two miRNAs were deregulated between SmCRC and MmCRC, hsa-miR-625-3p and has-miR-1269-3p. The combined data identified the IPO5 gene. Regardless of miRNA expression levels, the combined analysis resulted in 107 deregulated genes related to relaxin, estrogen, PI3K-Akt, WNT signaling pathways, and intracellular second messenger signaling. The intersection between our and validation sets confirmed the validity of our results. We have identified genes and pathways that may be considered as actionable targets in CRCLMs. Our data also provide a valuable resource for understanding molecular distinctions between SmCRC and MmCRC. They have the potential to enhance the diagnosis, prognostication, and management of CRCLMs by a molecularly targeted approach