Schweizerische Lehrerbildung im Urteil von Expertinnen und Experten

Im Rahmen des NFP 33-Teilprojektes "Wirksamkeit der Lehrerbildungssysteme in der Schweiz" wurden Experteninterviews mit Exponenten der deutschschweizerischen Lehrerbildung durchgeführt. In diesen Interviews wurden die Expertinnen und Experten um eine persönliche Einschätzung der Qualitäten der jeweiligen Lehrerausbildungsgänge gebeten. Die Ergebnisse von 27 Interviews mit Vertretern aus der Primar- und Sekundarlehrerausbildung sind im Folgenden zusammengestellt. Aus dem Spektrum der Einschätzungen kristallisieren sich zwei zentrale Aussagen heraus: Die Theorie-Praxis-Bezüge werden hochgehalten, eine Verbindung von Ausbildung und Berufseinstieg, wie sie in den meisten Ausbildungen noch aussteht, wird bemängelt

Lessons learned from challenging data science case studies

In this chapter, we revisit the conclusions and lessons learned of the chapters presented in Part II of this book and analyze them systematically. The goal of the chapter is threefold: firstly, it serves as a directory to the individual chapters, allowing readers to identify which chapters to focus on when they are interested either in a certain stage of the knowledge discovery process or in a certain data science method or application area. Secondly, the chapter serves as a digested, systematic summary of data science lessons that are relevant for data science practitioners. And lastly, we reflect on the perceptions of a broader public towards the methods and tools that we covered in this book and dare to give an outlook towards the future developments that will be influenced by them

Universal metrics to compare the effectiveness of climate change adaptation projects

Adaptation to climate change is increasingly supported through international financing. In contrast to mitigation, where the effectiveness of policy action can be measured through the metric "tonnes of CO2 equivalent reduced", no universally accepted metric for assessment of adaptation effectiveness exists. Without such a metric, adaptation finance vehicles such as the Adaptation Fund under the Kyoto Protocol encounter challenges when trying to compare the adaptive effect of ongoing or proposed projects in order to achieve an efficient allocation of their funds. The first experiences with adaptation funding show a tendency to use intermediate outcome indicators but no final impact metrics, similar to the state-of-art in development funding. This might lead to a backlash against adaptation funding by electorates in the North if the funding cannot show clear results. We assess two possible candidates for generic adaptation effectiveness metrics: 1) wealth saved from destruction through climate change impacts, and 2) disability-adjusted life years saved (DALYs), which are widely used in public health policy analysis. Apart from those two metrics we propose to use no-harm assessments in the environmental and cultural field. We discuss uncertainties encountered in applying these metrics, including the uncertain link between commonly reported outcome indicators and our metrics for saved wealth and health. The two metrics are tested by assessing five adaptation project proposals. Finally, we line out some ideas to handle these uncertainties, e.g. the use of regularly updated sectoral methodologies and agreed climate and economic models

Simultaneous and Sensitive Analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in Plasma after Oral Application of Small Doses of THC and Cannabis Extract

Besides the psychoactive Δ9-tetrahydrocannabinol (THC), hashish and marijuana as well as cannabis-based medicine extracts contain varying amounts of cannabidiol (CBD) and of the degradation product cannabinol (CBN). The additional determination of these compounds is interesting from forensic and medical points of view because it can be used for further proof of cannabis exposure and because CBD is known to modify the effects of THC. Therefore, a method for the simultaneous quantitative determination of THC, its metabolites 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH), CBD and CBN from plasma was developed. The method was based on automatic solid-phase extraction with C18 ec columns, derivatization with N,O-bistrimethylsilyltrifluoroacetamide (BSTFA), and gas chromatography-electron impact ionization-mass spectrometry (GC-EI-MS) with deuterated standards. The limits of detection were between 0.15 and 0.29 ng/mL for THC, 11-OH-THC, THC-COOH, and CBD and 1.1 ng/mL for CBN. The method was applied in a prospective pharmacokinetic study after single oral administration of 10 mg THC alone or together with 5.4 mg CBD in cannabis extract. The maximum plasma concentrations after cannabis extract administration ranged between 1.2 and 10.3 ng/mL (mean 4.05 ng/mL) for THC, 1.8 and 12.3 ng/mL (mean 4.9 ng/mL) for 11-OH-THC, 19 and 71 ng/mL (mean 35 ng/mL) for THC-COOH, and 0.2 and 2.6 ng/mL (mean 0.95 ng/mg) for CBD. The peak concentrations (mean values) of THC, 11-OH-THC, THC-COOH, and CBD were observed at 56, 82, 115, and 60 min, respectively, after intake. CBN was not detected. Caused by the strong first-pass metabolism, the concentrations of the metabolites were increased during the first hours after drug administration when compared to literature data for smoking. Therefore, the concentration ratio 11-OH-THC/THC was discussed as a criterion for distinguishing oral from inhalative cannabis consumptio

Remodeling of Axonal Connections Contributes to Recovery in an Animal Model of Multiple Sclerosis

In multiple sclerosis (MS), inflammation in the central nervous system (CNS) leads to damage of axons and myelin. Early during the clinical course, patients can compensate this damage, but little is known about the changes that underlie this improvement of neurological function. To study axonal changes that may contribute to recovery, we made use of an animal model of MS, which allows us to target inflammatory lesions to the corticospinal tract (CST), a major descending motor pathway. We demonstrate that axons remodel at multiple levels in response to a single neuroinflammatory lesion as follows: (a) surrounding the lesion, local interneurons show regenerative sprouting; (b) above the lesion, descending CST axons extend new collaterals that establish a “detour” circuit to the lumbar target area, whereas below the lesion, spared CST axons increase their terminal branching; and (c) in the motor cortex, the distribution of projection neurons is remodeled, and new neurons are recruited to the cortical motor pool. Behavioral tests directly show the importance of these changes for recovery. This paper provides evidence for a highly plastic response of the motor system to a single neuroinflammatory lesion. This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it

Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats

Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hyproxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes

One dimensional exciton luminescence induced by extended defects in nonpolar (Al,Ga)N/GaN quantum wells

In this study, we present the optical properties of nonpolar GaN/(Al,Ga)N single quantum wells (QWs) grown on either a- or m-plane GaN templates for Al contents set below 15%. In order to reduce the density of extended defects, the templates have been processed using the epitaxial lateral overgrowth technique. As expected for polarization-free heterostructures, the larger the QW width for a given Al content, the narrower the QW emission line. In structures with an Al content set to 5 or 10%, we also observe emission from excitons bound to the intersection of I1-type basal plane stacking faults (BSFs) with the QW. Similarly to what is seen in bulk material, the temperature dependence of BSF-bound QW exciton luminescence reveals intra-BSF localization. A qualitative model evidences the large spatial extension of the wavefunction of these BSF-bound QW excitons, making them extremely sensitive to potential fluctuations located in and away from BSF. Finally, polarization-dependent measurements show a strong emission anisotropy for BSF-bound QW excitons, which is related to their one-dimensional character and that confirms that the intersection between a BSF and a GaN/(Al,Ga)N QW can be described as a quantum wire