Evolution of the Dust Coma in Comet 67P/Churyumov-Gerasimenko Before 2009 Perihelion

Comet 67P/Churyumov-Gerasimenko is the main target of ESA's Rosetta mission and will be encountered in May 2014. As the spacecraft shall be in orbit the comet nucleus before and after release of the lander {\it Philae}, it is necessary necessary to know the conditions in the coma. Study the dust environment, including the dust production rate and its variations along its preperihelion orbit. The comet was observed during its approach to the Sun on four epochs between early-June 2008 and mid-January 2009, over a large range of heliocentric distances that will be covered by the mission in 2014. An anomalous enhancement of the coma dust density was measured towards the comet nucleus. The scalelength of this enhancement increased with decreasing heliocentric distance of the comet. This is interpreted as a result of an unusually slow expansion of the dust coma. Assuming a spherical symmetric coma, the average amount of dust as well as its ejection velocity have been derived. The latter increases exponentially with decreasing heliocentric distance (\rh), ranging from about 1 m/s at 3 AU to about 25-35 m/s at 1.4 AU. Based on these results we describe the dust environment at those nucleocentric distances at which the spacecraft will presumably be in orbit. Astronomy and Astrophysics, in pressComment: 5 pages, 4 figure

Distribution of Temperature and Strength in the Central Andean Lithosphere and Its Relationship to Seismicity and Active Deformation

We present three-dimensional (3D) models of the present-day steady-state conductive thermal field and strength distribution in the lithosphere beneath the Central Andes. Our primary objective was to investigate the influence that the structure of the Central Andean lithosphere has on its thermal and rheological state, and the relationship between the latter and the active deformation in the region. We used our previous data-driven and gravity-constrained 3D density model as starting point for the calculations. We first assigned lithology-derived thermal and rheological properties to the different divisions of the density model and defined temperature boundary conditions. We then calculated the 3D steady-state conductive thermal field and the maximum differential stresses for both brittle and ductile behaviors. We find that the thickness and composition of the crust are the main factors affecting the modeled thermal field, and consequently also the strength distribution. The orogen is characterized by a thick felsic crust with elevated temperatures and a low integrated strength, whereas the foreland and forearc are underlain by a more mafic and thinner crust with lower temperatures and a higher integrated strength. We find that most of the intraplate deformation coincides spatially with the steepest strength gradients and suggest that the high potential energy of the orogen together with the presence of rheological lateral heterogeneities produce high compressional stresses and strong strain localization along the margins of the orogen. We interpret earthquakes within the modeled ductile field to be related to the weakening effect of long-lived faults and/or the presence of seismic asperities.Fil: Ibarra, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Prezzi, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Bott, Judith. German Research Centre for Geosciences; AlemaniaFil: Scheck Wenderoth, Magdalena. German Research Centre for Geosciences; AlemaniaFil: Strecker, Manfred. Universitat Potsdam; Alemani

Timing and conditions of peak metamorphism and cooling across the Zimithang Thrust, Arunachal Pradesh, India

The Zimithang Thrust juxtaposes two lithotectonic units of the Greater Himalayan Sequence in Arunachal Pradesh, NE India. Monazite U–Pb, muscovite 40Ar/39Ar and thermobarometric data from rocks in the hanging and footwall constrain the timing and conditions of their juxtaposition across the structure, and their subsequent cooling. Monazite grains in biotite–sillimanite gneiss in the hanging wall yield LA-ICP-MS U–Pb ages of 16 ± 0.2 to 12.7 ± 0.4 Ma. A schistose gneiss within the high strain zone yields overlapping-to-younger monazite ages of 14.9 ± 0.3 to 11.5 ± 0.3 Ma. Garnet–staurolite–mica schists in the immediate footwall yield older monazite ages of 27.3 ± 0.6 to 17.1 ± 0.2 Ma. Temperature estimates from Ti-in-biotite and garnet–biotite thermometry suggest similar peak temperatures were achieved in the hanging and footwalls (~ 525–650 °C). Elevated temperatures of ~ 700 °C appear to have been reached in the high strain zone itself and in the footwall further from the thrust. Single grain fusion 40Ar/39Ar muscovite data from samples either side of the thrust yield ages of ~ 7 Ma, suggesting that movement along the thrust juxtaposed the two units by the time the closure temperature of Ar diffusion in muscovite had been reached. These data confirm previous suggestions that major orogen-parallel out-of-sequence structures disrupt the Greater Himalayan Sequence at different times during Himalayan evolution, and highlight an eastwards-younging trend in 40Ar/39Ar muscovite cooling ages at equivalent structural levels along Himalayan strike

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

Acidic extracellular pH is characteristic of the cell microenvironment in several important physiological and pathological contexts. Although it is well established that acidic extracellular pH can have profound effects on processes such as cell adhesion and migration, the underlying molecular mechanisms are largely unknown. Integrin receptors physically connect cells to the extracellular matrix, and are thus likely to modulate cell responses to extracellular conditions. Here, we examine the role of acidic extracellular pH in regulating activation of integrin [alpha]v[beta]3. Through computational molecular dynamics simulations, we find that acidic extracellular pH promotes opening of the [alpha]v[beta]3 headpiece, indicating that acidic pH can thereby facilitate integrin activation. This prediction is consistent with our flow cytometry and atomic force microscope-mediated force spectroscopy assays of integrin [alpha]v[beta]3 on live cells, which both demonstrate that acidic pH promotes activation at the intact cell surface. Finally, quantification of cell morphology and migration measurements shows that acidic extracellular pH affects cell behavior in a manner that is consistent with increased integrin activation. Taken together, these computational and experimental results suggest a new and complementary mechanism of integrin activation regulation, with associated implications for cell adhesion and migration in regions of altered pH that are relevant to wound healing and cancer.National Institute of Biomedical Imaging and Bioengineering (U.S.) (Award Number T32EB006348)Massachusetts Institute of Technology (Collamore-Rogers Fellowship)National Institutes of Health (U.S.) (NIH Cell Migration Consortium Grant U54-GM069668)National Science Foundation (U.S.) (CAREER Award)Singapore-MIT Alliance for Research and Technology (BioSystem and Micromechanics (BioSyM) Interdisciplinary Research Group

Heat shock factor HSFA2 fine-tunes resetting of thermomemory via plastidic metalloprotease FtsH6

Plants ´memorize´ stressful events and protect themselves from future, often more severe, stresses. To maximize growth after stress, plants ´reset´, or ´forget´, memories of stressful situations which requires an intricate balance between stress memory formation and the degree of forgetfulness. HEAT SHOCK PROTEIN 21 (HSP21) encodes a small HSP in plastids of Arabidopsis thaliana. Previous research found that HSP21 functions as a key component of thermomemory, which requires a sustained elevated level of HSP21 during the recovery from heat stress (HS). A heat-induced metalloprotease, filamentation temperature sensitive H6 (FtsH6), degrades HSP21 to establish pre-stress level, thereby resetting memory during the recovery phase. The transcription factor heat shock factor A2 (HSFA2) activates downstream genes essential for mounting thermomemory thereby acting as a positive regulator in the process. Here, by employing a yeast one-hybrid screen we additionally identify HSFA2 as an upstream transactivator of the resetting element FtsH6. Constitutive and inducible overexpression of HSFA2 increases expression of FtsH6 while it is drastically reduced in the hsfa2 knockout mutant. Chromatin immunoprecipitation reveals in planta binding of HSFA2 to the FtsH6 promoter. Importantly, overexpression of HSFA2 improves thermomemory more profoundly in ftsh6 than wild-type plants. Thus, by activating both memory-supporting and -resetting genes HSFA2 acts as a cellular homeostasis factor during thermomemory