Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents

OBJECTIVE: This study aimed to investigate the neural correlates of psychotic-like experiences in youth on measures of inhibitory control, reward anticipation and emotion processing. A secondary aim was to test whether these neuro-functional correlates of risk were predictive of psychotic symptoms 2 years later. METHOD: Functional imaging response to three paradigms: the Stop-Signal, Monetary Incentive Delay, and Faces tasks was collected in youth at age 14, as part of the IMAGEN study. At baseline, youth from London and Dublin sites were assessed on psychotic-like experiences and those reporting significant experiences were compared with matched controls. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1196). RESULTS: Youth reporting psychotic-like experiences showed increased hippocampus/amygdala activity during neutral faces processing and reduced dorsolateral prefrontal activity during failed inhibition relative to controls. The most prominent region for classifying 16-year olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) included hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use. CONCLUSIONS: The results stress the importance of the limbic network’s increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youth

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Imagerie de la mamelle chez la vache (radiographie, échographie, endoscopie)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Le Sexage du foetus par échographie chez la vache (étude de l'utilisation pratique sur le terrain)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Elaboration d'un CD-ROM sur les dystocies d'origine maternelle chez la jument

LYON1-BU Santé (693882101) / SudocSudocFranceF

Le Transfert embryonnaire par embryon transporté chez la jument, techniques, résultats et analyses

LYON1-BU Santé (693882101) / SudocSudocFranceF

Développement d'un modèle de suies pour la modélisation multidimentionnelle des polluants dans les moteurs diesel

ROUEN-INSA Madrillet (765752301) / SudocSudocFranceF

Elaboration d'un CD-ROM sur les dystocies d'origine foetale chez la jument

LYON1-BU Santé (693882101) / SudocSudocFranceF

LES AFFECTIONS DU PIED DU CHEVAL RESPONSABLES DE BOITERIE (DIAGNOSTIC DIFFERENTIEL, TRAITEMENT)

MARCY L'ETOILE-Ec.Nat.Vétéri (691272301) / SudocSudocFranceF

La Suppression de l'oestrus chez la jument

LYON1-BU Santé (693882101) / SudocSudocFranceF