Physio-Anatomical consideration of Upsneha & Upsweda with special reference to Garbh Poshan in Ayurveda - A Review

The science of Garbha Vyakaran has been always a subject of great interest for the persons devoted to it. The matter related to the concept of Garbha Vyakaran is systematically described in Ayurvedic literature. Nutrition of embryo mainly concerned with the mechanism involved in both the parts of mother and foetus to meet the requirements for growth and development during intra-uterine life. According to Ayurveda, it is the cessation of menses during pregnancy which affects the mammary glands of the breast and causes lactation for the post-natal feeding of the baby. Apart from the concept of nutritional supply through placenta which is well established in modern science, the relationship in between the changes occurring in the mother and in their body organs, have been tried to explain in the light of present knowledge

Diagnostic accuracy of saline infusion sonography as compared to hysteroscopy in premenopausal women with abnormal uterine bleeding

Background: In patients with abnormal uterine bleeding (AUB), differentiating whether the cause is anovulation or anatomic lesions can be challenging. Transvaginal sonography (TVS) has limitation in form of high false negative rate for diagnosing focal intrauterine pathology. To improve the image in TVS, saline injected into uterine cavity can be used as a negative contrast agent. Aim of our study was to evaluate the clinical value of saline infusion sonography (SIS) by comparing its diagnostic accuracy with that of established gold standard i.e. hysteroscopy.Methods: The study was carried out in a referral and teaching public sector hospital in eastern India from July 2015 to June 2016. Study population consisted of 136 premenopausal women with AUB, who were scheduled to undergo diagnostic hysteroscopy. Patients were first evaluated by sis and then followed by hysteroscopy on a later date.Results: Both SIS and hysteroscopy could be successfully performed in 136 out of 144 patients. When all findings by SIS (any pathological findings in uterine cavity vs. none) were combined and compared with hysteroscopy (gold standard), both sensitivity and specificity of sis were 0.88 whereas PPV and NPV were 0.85 and 0.90 respectively.Conclusions: Because of comparable results obtained by evaluating patients by SIS as well as office hysteroscopy, we recommend saline infusion sonography as a valuable tool for evaluating premenopausal women with abnormal uterine bleeding, before consideration for hysteroscopy

Effect of aquagenic and lithogenic factors on nephro, uretro and urolithiasis

Our study aims to explore different lithogenic and aquagenic factors which lead to the formation of renal calculi. To interpret this, a standard questionnaire is prepared based on the available review data which includes all the variable dietary information’s and other physiological parameters responsible for renal calculi. A study sample size of individuals (n=500) varies 19-65 years of age belongs to Delhi and NCR region. Of the 500 individuals more than 35 percent of individuals’ shows routine consumption of vegetables items includes eggplant, okra and ginger. 77 percent of the total individuals’ showed routine consumption of seasonal vegetables includes radish, carrot and spinach. 85 percent of the total shows routine uptake of whole wheat, grains, gram, black-pepper, soybean and nuts. 82 percent of the total individuals shows regular seasonal uptake of grapes while 35 percent of total shows routine uptake of strawberry and kiwi. Among beverage consumption 92 percent individuals takes tea, coffee, carbonated drink cola in routine while 46 percent takes Juice- apple, Grape, orange in routine and 75 percent takes whisky, beer, wine and other alcoholic beverages. In order to study the effect of potable water on the formation of renal calculi, water samples were collected from 20 different residential places (RPs) of Delhi- NCR and characterize for pH, calcium, magnesium and sodium

Comparative study of efficacy and safety of garenoxacin and moxifloxacin in acute exacerbation of chronic bronchitis in COPD patients

Background: Acute exacerbation of chronic bronchitis in COPD (AECB) is the major cause of morbidity, mortality and marked reduction in quality of life and imposes significant burden on both patients and healthcare systems. Bacterial infections causing AECB frequently require antibacterial treatment, so more evidences are needed to guide better antibiotic choice. Objective of the study was planned to compare efficacy and safety of Garenoxacin, a new fluoroquinolone versus moxifloxacin for treatment of Acute exacerbation of Chronic bronchitis in COPD patient.Methods: This was a prospective open label comparative study done in department of pharmacology and T.B & Chest of Government Medical College attached Dr Shusila Tiwari Hospital, Haldwani. 60 subjects with clinical symptoms suggestive of Anthonisen type II AECOPD (any two of following criteria: Increased dyspnea, cough, sputum purulence) were enrolled and randomized to receive either Moxifloxacin 400 mg once daily for 7 days or Garenoxacin 400mg once daily for 7 days. The primary outcome measure was clinical success rate at day 7 visit. Secondary outcome measures were changes in clinical global impression (CGI) scales and incidence of adverse events.Results: The mean age of patient was 60.98±9.9 years and 57.9±9.3 years in the Moxifloxacin and Garenoxacin groups. The clinical success rates were comparable with 86.2% in moxifloxacin group 84.6% and in garenoxacin group. Adverse effects were mild and self limiting. We observed two adverse effects in garenoxacin and three in moxifloxacin group.Conclusions: The result of study showed that garenoxacin is comparable to moxifloxacin in terms of efficacy and safety

Expectation of forward-backward rapidity correlations in p+pp+p collisions at the LHC energies

Forward-backward correlation strength ($b$) as a function of pesudorapidity intervals for experimental data from $p+\bar{p}$ non-singly diffractive collisions are compared to PYTHIA and PHOJET model calculations. The correlations are discussed as a function of rapidity window ($\Delta \eta$) symmetric about the central rapidity as well as rapidity window separated by a gap ($\eta_{gap}$) between forward and backward regions. While the correlations are observed to be independent of $\Delta \eta$, it is found to decrease with increase in $\eta_{gap}$. This reflects the role of short range correlations and justifies the use of $\eta_{gap}$ to obtain the accurate information about the physics of interest, the long range correlations. The experimental $b$ value shows a linear dependence on $\ln \sqrt{s}$ with the maximum value of unity being reached at $\sqrt{s}$ = 16 TeV, beyond the top LHC energy. However calculations from the PYTHIA and PHOJET models indicate a deviation from linear dependence on $\ln \sqrt{s}$ and saturation in the $b$ values being reached beyond $\sqrt{s}$ = 1.8 TeV. Such a saturation in correlation values could have interesting physical interpretations related to clan structures in particle production. Strong forward-backward correlations are associated with cluster production in the collisions. The average number of charged particles to which the clusters fragments, called the cluster size, are found to also increase linearly with $\ln \sqrt{s}$ for both data and the models studied. The rate of increase in cluster size vs. $\ln \sqrt{s}$ from models studied are larger compared to those from the data and higher for PHOJET compared to PYTHIA. Our study indicates that the forward-backward measurements will provide a clear distinguishing observable for the models studied at LHC energies.Comment: 15 pages, 14 Figures, accepted for publication in International Journal of Modern Physics

Induced Size Effects Of Gd3+ ions Doping On Structural And Magnetic Properties Of Ni-Zn Ferrite Nanoparticles

Gd3+ ions substituted in Ni0.5Zn0.5GdxFe2-xO4 (where x = 0.1, 0.2, 0.3) ferrite nanoparticles in the size range from 15 to 25 nm were prepared by chemical method. The effect of Gd3+ ions in spinel structure in correlation to structural and magnetic properties have been studied in detail using XRD, HRTEM and EPR techniques. The spin resonance confirms the ferromagnetic behaviour of these nanoparticles and higher order of dipolar-dipolar interaction. On increasing Gd3+ ions concentrations, the super exchange interaction i.e. increase in movement of electron among Gd3+ - O - Fe3+ in the core group and the spin biasing in the glass layer has been interpreted. The decrease in ‘g’ value and increase in relaxation time is well correlated with the change of particle size on different concentrations of Gd3+ ions in Ni-Zn ferrite

A clinical trial of treatment of uncomplicated typhoid fever: efficacy of ceftriaxone-azithromycin combination

Background: Typhoid fever is a systemic infection caused by Gram-negative bacterium Salmonella enterica serovar typhi (S. typhi). It is a major health problem in India. It carries significant morbidity and mortality. Antimicrobial therapy is critical for the management of typhoid fever. Emergence of multidrug-resistant (MDR) and nalidixic acid-resistant (NAR) strains of S. typhi has complicated therapy by limiting treatment options. Hence, this study was conducted to evaluate the efficacy and safety profile of ceftriaxone and azithromycin combination therapy in uncomplicated typhoid fever.Methods: Adults patients of blood culture proven uncomplicated typhoid fever admitted in the medicine ward of Teerthanker Mahaveer Medical College and Research Centre were treated with ceftriaxone intravenously (2 g daily for 14 days) and azithromycin orally (500 mg daily for 7 days). Patients were clinically and bacteriologically evaluated during the study period and follow-up.Results: 96% cure rate was observed. No relapse was recorded.Conclusion: Ceftriaxone-azithromycin combination may be considered as an empirical therapy for treatment of uncomplicated typhoid fever in view of the emergence of MDR and NAR strains of S. typhi

Can customer sentiment impact firm value? An integrated text mining approach

Developing measures to capture customer sentiment and securing a positive customer experience is a strategic necessity to improve firm profitability and shareholder value. The paper considers the relationship between customer satisfaction, earnings, and firm value as these drives change in stock prices, customer, and investor sentiment. The present study investigates the impact of customer sentiment polarity on stock prices based on Indian automobile sector databased such as the Indian Nifty Auto SNE (Maruti Suzuki, Tata Motors, and Eicher). A top-down approach is adopted to construct a financial proxy-based sentiment index completed with sentiment extracted from automobile news and customer reviews. The paper uses a text mining approach to holistically measure customer sentiment’s impact on investor sentiment and stock prices. The study was initially performed at the overall individual stock from the Nifty Auto NSE but focused on the top three passenger vehicle manufacturing companies i.e., Maruti Suzuki, Tata Motors, and Eicher. It was found that the sentiment index was augmented with news and customer reviews allows predicting more accurately NIFTY AUTO stock price movements. This implies that customer sentiment is a major driver of investor sentiment which in turn impacts the stock market and the firm value. Thus, the present study is an integrated approach to holistically measure customer sentiment’s impact on investor sentiment and stock prices.WOS:00071138140002

A Novel Hybrid Feature Selection Method for Day-Ahead Electricity Price Forecasting

The paper proposes a novel hybrid feature selection (FS) method for day-ahead electricity price forecasting. The work presents a novel hybrid FS algorithm for obtaining optimal feature set to gain optimal forecast accuracy. The performance of the proposed forecaster is compared with forecasters based on classification tree and regression tree. A hybrid FS method based on the elitist genetic algorithm (GA) and a tree-based method is applied for FS. Making use of selected features, aperformance test of the forecaster was carried out to establish the usefulness of the proposed approach. By way of analyzing and forecasts for day-ahead electricity prices in the Australian electricity markets, the proposed approach is evaluated and it has been established that, with the selected feature, the proposed forecaster consistently outperforms the forecaster with a larger feature set. The proposed method is simulated in MATLAB and WEKA software.publishedVersio