Q-advanced models for tsunami and rogue waves

A wavelet [subscript] Kq[/subscript] (t ) , that satisfies the q-advanced differential equation [superscript] K q [variant prime][/superscript] ( t ) =[subscript] K q[/subscript] (qt ) for q >1 , is used to model N-wave oscillations observed in tsunamis. Although q-advanced ODEs may seem nonphysical, we present an application that model tsunamis, in particular the Japanese tsunami of March 11, 2011, by utilizing a one-dimensional wave equation that is forced by [subscript] Fq[/subscript] ( t ,x ) =[subscript] Kq[/subscript] [subscript] (t )q[/subscript] Sin (x ) . The profile [subscript] F q[/subscript] is similar to tsunami models in present use. The function Sin [superscript] ( t ) [/superscript] q is a wavelet that satisfies a q-advanced harmonic oscillator equation. It is also shown that another wavelet, Cos [superscript] ( t ) [/superscript] q , matches a rogue-wave profile. This is explained in terms of a resonance wherein two small amplitude forcing waves eventually lead to a large amplitude rogue. Since wavelets are used in the detection of tsunamis and rogues, the signal-analysis performance of [subscript] K q[/subscript] and [superscript] Cos q [/superscript] is examined on actual data

Linearized T-matrix and Mie scattering computations

We present a new linearization of T-Matrix and Mie computations for light scattering by non-spherical and spherical particles, respectively. In addition to the usual extinc- tion and scattering cross-sections and the scattering matrix outputs, the linearized models will generate analytical derivatives of these optical properties with respect to the real and imaginary parts of the particle refractive index, and (for non-spherical scatterers) with respect to the ‘‘shape’’ parameter (the spheroid aspect ratio, cylinder diameter/height ratio, Chebyshev particle deformation factor). These derivatives are based on the essential linearity of Maxwell’s theory. Analytical derivatives are also available for polydisperse particle size distribution parameters such as the mode radius. The T-matrix formulation is based on the NASA Goddard Institute for Space Studies FORTRAN 77 code developed in the 1990s. The linearized scattering codes presented here are in FORTRAN 90 and will be made publicly available

Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure

Obstructive sleep apnea (OSA) is characterized by disrupted breathing and hypoxemia during sleep, daytime sleepiness, and changes in cognition and mood. One important question is regarding the reversibility of cognitive deficits after treatment with continuous positive airway pressure (CPAP). Here, we report the outcomes of CPAP treatment as measured by tests of attention and executive function. Thirty-seven individuals with moderate to severe OSA and compliant on CPAP treatment were studied with working memory tasks, neuropsychological testing, and overnight polysomnographic sleep study and compared to 27 healthy controls. CPAP improved the respiratory disturbance index, minimum and mean oxygen saturation (SpO2), subjective sleep quality, and daytime sleepiness ratings compared to pre-treatment values. In terms of current neurocognitive function, treated individuals with OSA performed at a comparable level to controls on basic working memory storage functions but still showed a significant reduction on tests of working memory requiring the central executive. The OSA group also performed worse on neuropsychological measures of complex attention, executive function, and psychomotor speed. While CPAP is an effective treatment for OSA in terms of ameliorating breathing disruption and oxygen desaturation during sleep, as well as daytime sleepiness, some cognitive deficits may be more resistant to treatment. (JINS, 2010, 16, 1077-1088.) Copyright © The International Neuropsychological Society 2010.published_or_final_versio

The Role of Daytime Sleepiness in Psychosocial Outcomes after Treatment for Obstructive Sleep Apnea

published_or_final_versio

Biodegradation of thiocyanate by a native groundwater microbial consortium

Gold ore processing typically generates large amounts of thiocyanate (SCN−)-contaminated effluent. When this effluent is stored in unlined tailings dams, contamination of the underlying aquifer can occur. The potential for bioremediation of SCN−-contaminated groundwater, either in situ or ex situ, remains largely unexplored. This study aimed to enrich and characterise SCN−-degrading microorganisms from mining-contaminated groundwater under a range of culturing conditions. Mildly acidic and suboxic groundwater, containing ∼135 mg L−1 SCN−, was collected from an aquifer below an unlined tailings dam. An SCN−-degrading consortium was enriched from contaminated groundwater using combinatory amendments of air, glucose and phosphate. Biodegradation occurred in all oxic cultures, except with the sole addition of glucose, but was inhibited by NH4+ and did not occur under anoxic conditions. The SCN−-degrading consortium was characterised using 16S and 18S rRNA gene sequencing, identifying a variety of heterotrophic taxa in addition to sulphur-oxidising bacteria. Interestingly, few recognised SCN−-degrading taxa were identified in significant abundance. These results provide both proof-of-concept and the required conditions for biostimulation of SCN− degradation in groundwater by native aquifer microorganisms

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

A number of new nucleoside derivatives are disclosed as inhibitors of DOT1L activity. SARs established that DOT1L inhibition could be achieved through incorporation of polar groups and small heterocycles at the 5-position (5, 6, 12) or by the application of alternative nitrogenous bases (18). Based on these results, CN-SAH (19) was identified as a potent and selective inhibitor of DOT1L activity where the polar 5-nitrile group was shown by crystallography to bind in the hydrophobic pocket of DOT1L. In addition, we show that a polar nitrile group can be used as a non-traditional replacement for heavy halogen atoms

Materials have driven the historical development of the Tennis Racket

© 2019 by the authors. The tennis racket has developed since the origins of Lawn Tennis in the 1870s. This study investigated how the tennis racket developed from 1874 to 2017, using measurements and material classifications for 525 samples. Racket measurements covered geometric, inertial and dynamic properties, and the number of strings. Rackets predating 1970 were mainly wooden, and typically characterised by head areas below 0.05 m2, masses over 350 g and natural frequencies below 120 Hz. Rackets from the 1970s were made from wood, metal and fibre-polymer composites, with most postdating 1980 made from fibre-polymer composites with a larger head, lower mass and higher natural frequency than their predecessors. Principal component analysis was used to reduce the dimensionality of the number of variables. Principal component one (PCA1) accounted for 35% of the variance in the measured racket properties, and was found to be significantly affected by material. Head width was best correlated with principal component one (r = 0.897, p < 0.001), followed by head length (r = 0.841, p < 0.001) and natural frequency (r = 0.813, p < 0.001). Early rackets were constrained by the limitations of wood, and the move to composites, which began in the 1970s, allowed this observed increase in head size and natural frequency. As material development has been a major driver of racket design in the past, we propose that new materials and manufacturing techniques, like additively manufactured composites, could further improve the tennis racket. The measurement techniques described here can be used to monitor developments in racket design

Bioinspired Autonomous Visual Vertical Control of a Quadrotor Unmanned Aerial Vehicle

Near-ground maneuvers, such as hover, approach, and landing, are key elements of autonomy in unmanned aerial vehicles. Such maneuvers have been tackled conventionally by measuring or estimating the velocity and the height above the ground, often using ultrasonic or laser range finders. Near-ground maneuvers are naturally mastered by flying birds and insects because objects below may be of interest for food or shelter. These animals perform such maneuvers efficiently using only the available vision and vestibular sensory information. In this paper, the time-to-contact (tau) theory, which conceptualizes the visual strategy with which many species are believed to approach objects, is presented as a solution for relative ground distance control for unmanned aerial vehicles. The paper shows how such an approach can be visually guided without knowledge of height and velocity relative to the ground. A control scheme that implements the tau strategy is developed employing only visual information from a monocular camera and an inertial measurement unit. To achieve reliable visual information at a high rate, a novel filtering system is proposed to complement the control system. The proposed system is implemented onboard an experimental quadrotor unmanned aerial vehicle and is shown to not only successfully land and approach ground, but also to enable the user to choose the dynamic characteristics of the approach. The methods presented in this paper are applicable to both aerial and space autonomous vehicles