A Simulation Games Approach to Suppliment the Teaching of Basic Economics Concepts in Elementary School

A year-long simulation game was created to facilitate the teaching of basic economics in a sixth and seventh grade middle school. The game could be adapted to implementation at lower grade levels. The students built two, table-top cities. They established a money system and were paid for positive behavior and effort. With their earned income and with loans from a bank, they purchased land, built homes, invested in business franchises, engaged in trade, and worked collectively to finance and build government projects and services. Discussion questions and evaluation tests were devloped, based upon the curriculum guidelines established by the Joint Council of Economic Education

A Stylistic Analysis of Fabrics, a Brass Quintet by John Stevens, a Lecture Recital, Together With Three Recitals of Selected Works of E. Gregson, B. Broughton, P. Hindemith, V. Holmboe, H. Stevens, J. S. Bach, and Others

A stylistic analysis of John Stevens' second brass quintet, Fabrics, which discusses the composer's use of orchestration, harmonic language, rhythmic activity, melodic and formal considerations, and performance practice issues. Collaboration between composer and performer is investigated, particularly through Stevens' status as member of the Wisconsin Brass Quintet, the ensemble for which Fabrics was composed. Biographical information about Stevens and the Wisconsin Brass Quintet is provided, with appendices providing information regarding Stevens' activities as composer and performer and the activities of the Wisconsin Brass Quintet. Stevens was extensively interviewed as source material for this dissertation

Long-term treatment of uterine fibroids with ulipristal acetate

Objective: To investigate the efficacy and safety of ulipristal acetate (UPA) for long-term treatment of symptomatic uterine fibroids.<p></p> Design: Repeated intermittent open-label UPA courses, each followed by randomized double-blind norethisterone acetate (NETA) or placebo.<p></p> Setting: European clinical gynecology centers.<p></p> Patient(s): Two hundred and nine women with symptomatic fibroids including heavy menstrual bleeding.<p></p> Intervention(s): Patients received up to four 3-month courses of UPA 10 mg daily, immediately followed by 10-day double-blind treatment with NETA (10 mg daily) or placebo.<p></p> Main Outcome Measure(s): Amenorrhea, fibroid volume, endometrial histology.<p></p> Result(s): After the first UPA course, amenorrhea occurred in 79% of women, with median onset (from treatment start) of 4 days (interquartile range, 2–6 days). Median fibroid volume change was −45% (interquartile range, −66%; −25%). Amenorrhea rates were 89%, 88%, and 90% for the 131, 119, and 107 women who received treatment courses 2, 3, and 4, respectively. Median times to amenorrhea were 2, 3, and 3 days for treatment courses 2, 3, and 4, respectively. Median fibroid volume changes from baseline were −63%, −67%, and −72% after treatment courses 2, 3, and 4, respectively. All endometrial biopsies showed benign histology without hyperplasia; NETA did not affect fibroid volume or endometrial histology.<p></p> Conclusion(s): Repeated 3-month UPA courses effectively control bleeding and shrink fibroids in patients with symptomatic fibroids

A substudy of a randomized controlled trial

Data on early markers for acute kidney injury (AKI) after noncardiovascular surgery are still limited. This study aimed to determine the diagnostic value of plasma neutrophil-gelatinase-associated lipocalin (pNGAL) and intraoperative diuresis for AKI in patients undergoing major abdominal surgery treated within a goal-directed hemodynamic algorithm. This study is a post-hoc analysis of a randomized controlled pilot trial comparing intravenous solutions within a hemodynamic goal-directed algorithm based on the esophageal Doppler in patients undergoing epithelial ovarian cancer surgery. The diagnostic value of plasma NGAL obtained at ICU admission and intraoperative diuresis was determined with respect to patients already meeting AKI criteria 6 hours after surgery (AKI6h) and to all patients meeting AKI criteria at least once during the postoperative course (AKItotal). AKI was diagnosed by the definition of the Kidney Disease Improving Global Outcome (KDIGO) group creatinine criteria and was screened up to postoperative day 3. Receiver operating characteristic curves including a gray zone approach were performed. A total of 48 patients were analyzed. None of the patients had increased creatinine levels before surgery and 14 patients (29.2%) developed AKI after surgery. Plasma NGAL was predictive for AKI6h (AUCAKI6h 0.832 (95% confidence interval [CI], 0.629–0.976), P = .001) and AKItotal (AUCAKItotal 0.710 (CI 0.511–0.878), P = .023). The gray zones of pNGAL calculated for AKI6h and AKItotal were 210 to 245 and 207 to 274 ng mL−1, respectively. The lower cutoffs of the gray zone at 207 and 210 ng mL−1 had a negative predictive value (NPV) (i.e., no AKI during the postoperative course) of 96.8% (CI 90–100) and 87.1% (CI 78–97), respectively. Intraoperative diuresis was also predictive for AKI6h (AUCAKI6h 0.742 (CI 0.581–0.871), P = .019) with a gray zone of 0.5 to 2.0 mL kg−1 h−1. At the lower cutoff of the gray zone at 0.5 mL kg−1 h−1, corresponding to the oliguric threshold, the NPV was 84.2% (78–92). This study indicates that pNGAL can be used as an early marker to rule out AKI occurring within 3 days after major abdominal surgery. Intraoperative diuresis can be used to rule out AKI occurring up to 6 hours after surgery

Phaeoacremonium tuscanicum and Phaeoacremonium indicum sp. nov. associated with subcutaneous phaeohyphomycosis

Two cases of phaeohyphomycotic infections were caused by Phaeoacremonium tuscanicum, not previously identified in human infections, and one new species, Phaeoacremonium indicum, respectively. Morphological and cultural investigation as well as phylogenetic analysis was constructed based on maximum likelihood analyses using actin and -tubulin sequences to identify the fungal isolates.The authors acknowledge the contribution to the isolation and identification of the Phaeoacremonium indicum isolate made by: A.A. Padhye and A. Sivaraman (PSG Institute of Medical Science and Research, Coimbatore), S. Verghese (Frontier Life Line Private Limited, Mogappair), P. Ravichandran (Kidney Diseases and Institute of Organ Transplantation, St. Thomas Hospital, Chennai), Tay Sun Tee (Department of Medical Microbiology, University of Malaya), and Mary E. Brandt (Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta).Peer reviewe

Developing New Value Chains for Small‐Scale and Emerging Cattle Farmers in South Africa

In this paper we look back on the first year of a three‐year project which aims to undertake the researchnecessary to develop a wider range of market outlets, products and value chains for beef produced by thesmall‐scale and emerging sector in South Africa. We discuss the difficulties encountered in designing andimplementing the project, and we review progress towards achieving the economic, social and environmentaloutcomes that we are seeking

Science and society: The Role of Long-term Studies in Environmental Stewardship

Long-term research should play a crucial role in addressing grand challenges in environmental stewardship. We examine the efforts of five Long Term Ecological Research Network sites to enhance policy, management, and conservation decisions for forest ecosystems. In these case studies, we explore the approaches used to inform policy on atmospheric deposition, public land management, land conservation, and urban forestry, including decisionmaker engagement and integration of local knowledge, application of models to analyze the potential consequences of policy and management decisions, and adaptive management to generate new knowledge and incorporate it into decisionmaking. Efforts to enhance the role of long-term research in informing major environmental challenges would benefit from the development of metrics to evaluate impact; stronger partnerships among research sites, professional societies, decisionmakers, and journalists; and greater investment in efforts to develop, test, and expand practice-based experiments at the interface of science and society