Niederdeutsch in der Grundschule:Unterrichtsmaterialien für die 3./4. Klasse an Grundschulen im Münsterland

Die niederdeutschen Dialekte waren bis zum Beginn des 20. Jahrhunderts in Westfalen wichtigste Alltags- und Verkehrssprache. Nicht nur in den Familien wurde Niederdeutsch gesprochen, auch noch oft auf öffentlichen Plätzen, im Handel oder in den Rathäusern. Bis heute ist das Niederdeutsche in vielen kulturellen Bereichen präsent, so im niederdeutschen Theater oder in Form von zahlreichen niederdeutschen Buchpublikationen. Es lässt sich jedoch nicht übersehen, dass die Sprache ihre Rolle als Alltagssprache weitestgehend eingebüßt hat. Um dieser Entwicklung entgegen zu wirken, bedarf es Anstrengungen aus unterschiedlichen Richtungen. Ein möglicher Ansatzpunkt ist, das Interesse von Kindern und Jugendlichen an der alten Regionalsprache zu wecken. Hierzu leisten die vorliegenden Unterrichtsmaterialien, die sich an Dritt- und Viertklässler an Grundschulen im Münsterland richten, einen Beitrag. In fünf Unterrichtseinheiten, die didaktisch aufbereitetes Material für über 30 Unterrichtsstunden bereithalten, können am Niederdeutschen interessierte Kinder die Sprache in unterschiedlichsten Alltagskontexten kennen lernen und einfache praktische Kenntnisse erwerben. Die Lernenden sollen für die sprachlichen Besonderheiten des Niederdeutschen sensibilisiert werden und erkennen, dass die Sprache auch heute noch in vielen Kontexten präsent ist, sei es in vielen niederdeutschen Straßennamen oder in Begriffen der Alltagsprache wie 'Kopp' oder 'Pott'

Subjektive und objektive Daten in der Sprachwandelforschung.: Ergebnisse aus dem deutsch-niederländischen Grenzgebiet

Language change is generally regarded as change of linguistic items or of the language system. In this sense it might be described and explained by the observation of varying use and evaluation of language. Developments concerning the conditions of use and the characteristics of evaluation are rarely regarded as cases of language change itself. Recently, however, there seems to be a shift towards a wider understanding of language change, distinguishing change of structure, use and evaluation. This shift is accompanied by the distinction of subjective and objective language data. Studies that combine objective and subjective data enable a comprehensive view of the characteristics and causes of language change. The present paper uses data from speakers of two different age groups from the Grafschaft Bentheim district on the German-Dutch border to illustrate the mutual dependency of structural and evaluative language change. The investigation will be carried out in an apparent-time-analysis based on a translation tasks (as a type of objective data) and semantic differentials (subjective data). Although the attested differences between the age groups turned out to be comparatively small, there are correlations between the results regarding subjective and objective data to be stated

In Things We Trust? Towards trustability in the Internet of Things

This essay discusses the main privacy, security and trustability issues with the Internet of Things

Servicio SURAD, 2011 primer año de funcionamiento

1 copia .pdf del póster original, presentado en tamaño din A0 en las 4as Jornadas de Análisis de la Red de Bibliotecas del CSIC (Madrid. 26-27 abril, 2012). Más información de las Jornadas en: http://jornadas.urici.csic.es/IVjornadas/El servicio SURAD presenta los resultados del 2011, su primer año de actividad. SURAD es el servicio de localización y suministro de documentos científicos para la comunidad investigadora del CSIC, que atiende aquellas solicitudes que no pueden gestionar en primera instancia sus bibliotecas. SURAD se gestiona a través de la Unidad de Recursos de la Información Científica para la Investigación y integrado dentro del Plan 100% Digital del CSIC. Su objetivo es dar un servicio de acceso al documento a la comunidad científica del CSIC que carece de servicio de biblioteca presencial en su centro/instituto y actuar como servicio de último recurso de obtención de documentos para las bibliotecas de la Red, proporcionando los documentos que éstas no puedan obtener.Peer reviewe

Does the Constitution Provide More Ballot Access Protection for Presidential Elections Than for U.S. House Elections?

Both the U.S. Constitution and The Federalist Papers suggest that voters ought to have more freedom to vote for the candidate of their choice for the U.S. House of Representatives than they do for the President or the U.S. Senate. Yet, strangely, for the last thirty-three years, the U.S. Supreme Court and lower courts have ruled that the Constitution gives voters more freedom to vote for the candidate of their choice in presidential elections than in congressional elections. Also, state legislatures, which have been writing ballot access laws since 1888, have passed laws that make it easier for minor-party and independent candidates to get on the ballot for President than for the U.S. House. As a result, voters in virtually every state invariably have far more choices on their general election ballots for the President than they do for the House. This Article argues that the right of a voter to vote for someone other than a Democrat or a Republican for the House is just as important as a voter’s right to do so for President, and that courts should grant more ballot access protection to minor-party and independent candidates for the House

The Chicken Yolk Sac IgY Receptor, a Mammalian Mannose Receptor Family Member, Transcytoses IgY across Polarized Epithelial Cells

In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers. In birds, maternal IgY in egg yolk is transferred across the yolk sac to passively immunize chicks during gestation and early independent life. The chicken yolk sac IgY receptor (FcRY) is the ortholog of the mammalian phospholipase A2 receptor, a mannose receptor family member, rather than an FcRn or MHC homolog. FcRn and FcRY both exhibit ligand binding at the acidic pH of endosomes and ligand release at the slightly basic pH of blood. Here we show that FcRY expressed in polarized mammalian epithelial cells functioned in endocytosis, bidirectional transcytosis, and recycling of chicken FcY/IgY. Confocal immunofluorescence studies demonstrated that IgY binding and endocytosis occurred at acidic but not basic pH, mimicking pH-dependent uptake of IgG by FcRn. Colocalization studies showed FcRY-mediated internalization via clathrin-coated pits and transport involving early and recycling endosomes. Disruption of microtubules partially inhibited apical-to-basolateral and basolateral-to-apical transcytosis, but not recycling, suggesting the use of different trafficking machinery. Our results represent the first cell biological evidence of functional equivalence between FcRY and FcRn and provide an intriguing example of how evolution can give rise to systems in which similar biological requirements in different species are satisfied utilizing distinct protein folds

Testing the daytime oxidizing capacity of the troposphere: 1994 OH field campaign at the Izaña Observatory, Tenerife

A field campaign was carried out during May 1994 at the Izaña station, Tenerife. This campaign was part of the program Environment and Climate sponsored by the European Commission to study the influence of European emissions on the oxidizing capacity of a clean tropospheric environment. Daytime and also nighttime measurements were made, covering the OH as well as the NO3 chemistry. This paper presents the OH measurements taken with a multipass optical absorption spectrometer (MOAS) and discusses the daytime chemistry in a statistical and therefore more preliminary way. All relevant parameters influencing the OH concentration were monitored. From the data the two main contributions to the OH production can clearly be discerned and are given by the primary production following the ozone photolysis and the O(1D)-H2O reaction and by the catalytic reactions of NOx in the recycling process. The latter processes prove to contribute a dominant part to the OH concentration. The measurements of the nonmethane hydrocarbons (NMHC) especially of the biogenics, indicate a considerable influence of the NMHC on the absolute values of the OH concentration at Tenerife.This work has been financially supported by the European Commission (grant EV5V-CT93-0321), by the DFG, and by the Fonds der Chemischen Industrie, which is gratefully acknowledged

A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

Background:The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR-371-373 and miR-302/367 clusters are overexpressed in all malignant GCTs, and some of these miRNAs show elevated serum levels at diagnosis. Here, we developed a robust technical pipeline to quantify these miRNAs in the serum and cerebrospinal fluid (CSF). The pipeline was used in samples from a cohort of exclusively paediatric patients with gonadal and extragonadal malignant GCTs, compared with appropriate tumour and non-tumour control groups.Methods:We developed a method for miRNA quantification that enabled sample adequacy assessment and reliable data normalisation. We performed qRT-PCR profiling for miR-371-373 and miR-302/367 cluster miRNAs in a total of 45 serum and CSF samples, obtained from 25 paediatric patients.Results:The exogenous non-human spike-in cel-miR-39-3p and the endogenous housekeeper miR-30b-5p were optimal for obtaining robust serum and CSF qRT-PCR quantification. A four-serum miRNA panel (miR-371a-3p, miR-372-3p, miR-373-3p and miR-367-3p): (i) showed high sensitivity/specificity for diagnosing paediatric extracranial malignant GCT; (ii) allowed early detection of relapse of a testicular mixed malignant GCT; and (iii) distinguished intracranial malignant GCT from intracranial non-GCT tumours at diagnosis, using CSF and serum samples.Conclusions:The pipeline we have developed is robust, scalable and transferable. It potentially promises to improve clinical management of paediatric (and adult) malignant GCTs