GPS scintillations associated with cusp dynamics and polar cap patches

This paper investigates the relative scintillation level associated with cusp dynamics (including precipitation, flow shears, etc.) with and without the formation of polar cap patches around the cusp inflow region by the EISCAT Svalbard radar (ESR) and two GPS scintillation receivers. A series of polar cap patches were observed by the ESR between 8:40 and 10:20 UT on December 3, 2011. The polar cap patches combined with the auroral dynamics were associated with a significantly higher GPS phase scintillation level (up to 0.6 rad) than those observed for the other two alternatives, i.e., cusp dynamics without polar cap patches, and polar cap patches without cusp aurora. The cusp auroral dynamics without plasma patches were indeed related to GPS phase scintillations at a moderate level (up to 0.3 rad). The polar cap patches away from the active cusp were associated with sporadic and moderate GPS phase scintillations (up to 0.2 rad). The main conclusion is that the worst global navigation satellite system space weather events on the dayside occur when polar cap patches enter the polar cap and are subject to particle precipitation and flow shears, which is analogous to the nightside when polar cap patches exit the polar cap and enter the auroral oval

Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis

Echinococcus granulosus and Echinococcus multilocularis are cestode parasites, of which the metacestode (larval) stages cause the diseases cystic echinococcosis (CE) and alveolar echinococcosis (AE), respectively. Albendazole and mebendazole are presently used for chemotherapeutical treatment. However, these benzimidazoles do not appear to be parasiticidal in vivo against AE. In addition, failures in drug treatments as well as the occurrence of side-effects have been reported. New drugs are needed to cure AE and CE, which are considered to be neglected diseases. Strategies currently being implemented to identify novel chemotherapeutical treatment options include (i) conventional primary in vitro testing of broad-spectrum anti-infective drugs, either in parallel with, or followed by, animal experimentation; (ii) studies of drugs which interfere with the proliferation of cancer cells and of Echinococcus metacestodes; (iii) exploitation of the similarities between the parasite and mammalian signalling machineries, with a special focus on targeting specific signalling receptors; (iv) in silico approaches, employing the current Echinococcus genomic database information to search for suitable targets for compounds with known modes of action. In the present article, we review the efforts toward obtaining better anti-parasitic compounds which have been undertaken to improve chemotherapeutical treatment of echinococcosis, and summarize the achievements in the field of host-parasite interactions which may also lead to new immuno-therapeutical option

2022 Tonga Volcanic Eruption Induced Global Propagation of Ionospheric Disturbances via Lamb Waves

The Tonga volcano eruption at 04:14:45 UT on 2022-01-15 released enormous amounts of energy into the atmosphere, triggering very significant geophysical variations not only in the immediate proximity of the epicenter but also globally across the whole atmosphere. This study provides a global picture of ionospheric disturbances over an extended period for at least 4 days. We find traveling ionospheric disturbances (TIDs) radially outbound and inbound along entire Great-Circle loci at primary speeds of ∼300–350 m/s (depending on the propagation direction) and 500–1,000 km horizontal wavelength for front shocks, going around the globe for three times, passing six times over the continental US in 100 h since the eruption. TIDs following the shock fronts developed for ∼8 h with 10–30 min predominant periods in near- and far- fields. TID global propagation is consistent with the effect of Lamb waves which travel at the speed of sound. Although these oscillations are often confined to the troposphere, Lamb wave energy is known to leak into the thermosphere through channels such as atmospheric resonance at acoustic and gravity wave frequencies, carrying substantial wave amplitudes at high altitudes. Prevailing Lamb waves have been reported in the literature as atmospheric responses to the gigantic Krakatoa eruption in 1883 and other geohazards. This study provides substantial first evidence of their long-duration imprints up in the global ionosphere. This study was enabled by ionospheric measurements from 5,000+ world-wide Global Navigation Satellite System (GNSS) ground receivers, demonstrating the broad implication of the ionosphere measurement as a sensitive detector for atmospheric waves and geophysical disturbances

Qualitative modelling and analysis of regulations in multi-cellular systems using Petri nets and topological collections

In this paper, we aim at modelling and analyzing the regulation processes in multi-cellular biological systems, in particular tissues. The modelling framework is based on interconnected logical regulatory networks a la Rene Thomas equipped with information about their spatial relationships. The semantics of such models is expressed through colored Petri nets to implement regulation rules, combined with topological collections to implement the spatial information. Some constraints are put on the the representation of spatial information in order to preserve the possibility of an enumerative and exhaustive state space exploration. This paper presents the modelling framework, its semantics, as well as a prototype implementation that allowed preliminary experimentation on some applications.Comment: In Proceedings MeCBIC 2010, arXiv:1011.005

Dayside Field-Aligned Current Impacts on Ionospheric Irregularities

Global Navigation Satellite Systems (GNSS) are subject to disturbances caused by plasma irregularities in the ionosphere. Studies have suggested that in addition to the gradient drift and Kelvin‐Helmholtz instabilities, electron precipitation may be important for phase scintillations in the dayside auroral region. This study combines in situ Swarm data with ground GNSS observations to investigate the potential role of filamentary field‐aligned currents (FACs) on phase scintillations in the dayside auroral region by analyzing 22 events with phase scintillations exceeding 0.45 radians. We observe colocation between regions of severe phase scintillations and highly filamented FACs with fluctuations measured in the spacecraft frame of the order of 20 Hz. The observations indicate that filamentary FACs are crucial drivers for irregularities responsible for creating severe phase scintillations measured in the dayside auroral region and are thus of significant importance in the context of space weather impact on satellite communication.publishedVersio

Simultaneous Global Ionospheric Disturbances Associated With Penetration Electric Fields During Intense and Minor Solar and Geomagnetic Disturbances

A new observational phenomenon, named Simultaneous Global Ionospheric Density Disturbance (SGD), is identified in GNSS total electron content (TEC) data during periods of three typical geospace disturbances: a Coronal Mass Ejection-driven severe disturbance event, a high-speed stream event, and a minor disturbance day with a maximum Kp of 4. SGDs occur frequently on dayside and dawn sectors, with a ∼1% TEC increase. Notably, SGDs can occur under minor solar-geomagnetic disturbances. SGDs are likely caused by penetration electric fields (PEFs) of solar-geomagnetic origin, as they are associated with Bz southward, increased auroral AL/AU, and solar wind pressure enhancements. These findings offer new insights into the nature of PEFs and their ionospheric impact while confirming some key earlier results obtained through alternative methods. Importantly, the accessibility of extensive GNSS networks, with at least 6,000 globally distributed receivers for ionospheric research, means that rich PEF information can be acquired, offering researchers numerous opportunities to investigate geospace electrodynamics

Enhanced Formation of Nanometric Titanium Cones by Incorporation of Titanium, Tungsten and/or Iron in a Helium Ion Beam

Surface patterning of bio-compatible titanium (Ti) shows a growing interest in the medical field. The engineering of material surfaces can achieve bactericidal properties and osteointegration improvements in order to develop medical implants. Spikes-like surface morphologies have already demonstrated the development of promising bactericidal properties. A barely new method to produce nanometric-sized cones on titanium consists of helium (He) ion irradiation using low energies ( 100 eV) and temperatures comprised between 0.25 T/T 0.5 (with T being the melting temperature of the material). Ti, iron (Fe) and/or tungsten (W) were incorporated in a He beam, and their amounts were quantified using X-ray Photoelectron Spectroscopy (XPS). The He ion energy was varied from 70 and 120 eV, the surface temperatures from 571 to 651 K for fluences approximately equal to 1024 m−2. After irradiation, the surface morphology was characterized using Scanning Electron Microscopy (SEM) and Focused Ion Beam (FIB). This study demonstrated the capability for irradiated Ti surfaces to form cones with tunable density, aspect ratio, and heights with the incorporation of Ti, Fe and/or W in a He ion. Additionally, the growth rate of the cones was enhanced by about 30 times in comparison to pure He irradiation as a function of the chosen materials introduced in the He beam

Initial oak regeneration responses to experimental warming along microclimatic and macroclimatic gradients

Quercus spp. are one of the most important tree genera in temperate deciduous forests in terms of biodiversity, economic and cultural perspectives. However, natural regeneration of oaks, depending on specific environmental conditions, is still not sufficiently understood. Oak regeneration dynamics are impacted by climate change, but these climate impacts will depend on local forest management and light and temperature conditions. Here, we studied germination, survival and seedling performance (i.e. aboveground biomass, height, root collar diameter and specific leaf area) of four oak species (Q. cerris, Q. ilex, Q. robur and Q. petraea). Acorns were sown across a wide latitudinal gradient, from Italy to Sweden, and across several microclimatic gradients located within and beyond the species' natural ranges. Microclimatic gradients were applied in terms of forest structure, distance to the forest edge and experimental warming. We found strong interactions between species and latitude, as well as between microclimate and latitude or species. The species thus reacted differently to local and regional changes in light and temperature ; in southern regions the temperate Q. robur and Q. petraea performed best in plots with a complex structure, whereas the Mediterranean Q. ilex and Q. cerris performed better in simply structured forests with a reduced microclimatic buffering capacity. The experimental warming treatment only enhanced height and aboveground biomass of Mediterranean species. Our results show that local microclimatic gradients play a key role in the initial stages of oak regeneration; however, one needs to consider the species-specific responses to forest structure and the macroclimatic context