Effects of Horizontal-Control Planform and Wing-Leading-Edge Modification on Low-Speed Longitudinal Aerodynamic Characteristics of a Canard Airplane Configuration

An investigation at low subsonic speeds has been conducted in the Langley 300-MPH 7- by 10-foot tunnel. The basic wing had a trapezoidal planform, an aspect ratio of 3.0., a taper ratio of 0.143, and an unswept 80-percent-chord line. Modifications to the basic wing included deflectable full-span and partial-span leading-edge chord-extensions. A trapezoidal horizontal control similar in planform to the basic wing and a 60 deg sweptback delta horizontal control were tested in conjunction with the wing. The total planform area of each horizontal control was 16 percent of the total basic-wing area. Modifications to these horizontal controls included addition of a full-span chord-extension to the trapezoidal planform and a fence to the delta planform

Effects of Canard Planform and Wing-Leading-Edge Modification on Low-Speed Longitudinal Aerodynamic Characteristics of a Canard Airplane Configuration

An investigation has been conducted at low subsonic speeds to study the effects of canard planform and wing-leading-edge modification on the longitudinal aerodynamic characteristics of a general research canard airplane configuration. The basic wing of the model had a trapezoidal planform, an aspect ratio of 3.0, a taper ratio of 0.143, and an unswept 80-percent-chord line. Modifications to the wing included addition of full-span and partial-span leading-edge chord-extensions. Two canard planforms were employed in the study; one was a 60 deg sweptback delta planform and the other was a trapezoidal planform similar to that of the basic wing. Modifications to these canards included addition of a full-span leading-edge chord-extension to the trapezoidal planform and a fence to the delta planform. For the basic-wing-trapezoidal-canard configuration, rather abrupt increases in stability occurred at about 12 deg angle of attack. A slight pitch-up tendency occurred for the delta-canard configuration at approximately 8 deg angle of attack. A comparison of the longitudinal control effectiveness for the basic-wing-trapezoidal-canard combination and for the basic-wing-delta-canard combination indicates higher values of control effectiveness at law angles of attack for the trapezoidal canard. The control effectiveness for the delta-canard configuration, however, is seen to hold up for higher canard deflections and to higher angles of attack. Use of a full-span chord-extension deflected approximately 30 deg on the trapezoidal canard greatly improved the control characteristics of this configuration and enabled a sizeable increase in trim lift to be realized

Supersonic Aerodynamic Characteristics of a Space Shuttle Orbiter Model at Angles of Attack from 20 Deg to 90 Deg

Space Shuttle Orbiter aerodynamic characteristics have been determined in the angle-of-attack range from 20 to 90 degrees and Mach numbers from 4.60 to 1.80 at Reynolds numbers, based on body length, of 2.15 x 10 to the 6th and 4.30 x 10 to the 6th power. Emphasis is on vehicle stability, control, and trim characteristics above a 60 degree angle of attack. The model used was a 0.986 percent scale Orbiter, having a blade-mounted support system entering the model in the region of the vertical tail. Elevon deflections of 0, -10, -20, and -40 degrees and body-flap deflections of 0, +6 and -12 degrees were investigated individually and in combination. Schlieren photographs are also presented for selected configurations and Mach numbers. The Orbiter was found to be longitudinally stable and trimmable in the angle-of-attack range from approximately 60 to 80 degrees. Both the elevon and body flap provided positive pitch control-effectiveness at angles of attack from 60 to 80 degrees and the Mach numbers of this study. For the range of neutral to stable trim in the angle-of-attack range above about 55 degrees, the deflected elevon/body-flap combination provided positive trimmed lift and lift/drag ratios

A study to determine methods of improving the subsonic performance of a proposed Personnel Launch System (PLS) concept

An investigation has been conducted in the Langley 7- by 10-Foot High Speed Wind Tunnel to determine the longitudinal and lateral directional aerodynamic characteristics of a series of personnel launch system concepts. This series of configurations evolved during an effort to improve the subsonic characteristics of a proposed lifting entry vehicle (designated the HL-20). The primary purpose of the overall investigation was to provide a vehicle concept which was inherently stable and trimable from entry to landing while examining methods of improving subsonic aerodynamic performance

Planck intermediate results. XLI. A map of lensing-induced B-modes

The secondary cosmic microwave background (CMB) $B$-modes stem from the post-decoupling distortion of the polarization $E$-modes due to the gravitational lensing effect of large-scale structures. These lensing-induced $B$-modes constitute both a valuable probe of the dark matter distribution and an important contaminant for the extraction of the primary CMB $B$-modes from inflation. Planck provides accurate nearly all-sky measurements of both the polarization $E$-modes and the integrated mass distribution via the reconstruction of the CMB lensing potential. By combining these two data products, we have produced an all-sky template map of the lensing-induced $B$-modes using a real-space algorithm that minimizes the impact of sky masks. The cross-correlation of this template with an observed (primordial and secondary) $B$-mode map can be used to measure the lensing $B$-mode power spectrum at multipoles up to $2000$. In particular, when cross-correlating with the $B$-mode contribution directly derived from the Planck polarization maps, we obtain lensing-induced $B$-mode power spectrum measurement at a significance level of $12\,\sigma$, which agrees with the theoretical expectation derived from the Planck best-fit $\Lambda$CDM model. This unique nearly all-sky secondary $B$-mode template, which includes the lensing-induced information from intermediate to small ($10\lesssim \ell\lesssim 1000$) angular scales, is delivered as part of the Planck 2015 public data release. It will be particularly useful for experiments searching for primordial $B$-modes, such as BICEP2/Keck Array or LiteBIRD, since it will enable an estimate to be made of the lensing-induced contribution to the measured total CMB $B$-modes.Comment: 20 pages, 12 figures; Accepted for publication in A&A; The B-mode map is part of the PR2-2015 Cosmology Products; available as Lensing Products in the Planck Legacy Archive http://pla.esac.esa.int/pla/#cosmology; and described in the 'Explanatory Supplement' https://wiki.cosmos.esa.int/planckpla2015/index.php/Specially_processed_maps#2015_Lensing-induced_B-mode_ma

Impairment of Gradual Muscle Adjustment during Wrist Circumduction in Parkinson's Disease

Purposeful movements are attained by gradually adjusted activity of opposite muscles, or synergists. This requires a motor system that adequately modulates initiation and inhibition of movement and selectively activates the appropriate muscles. In patients with Parkinson's disease (PD) initiation and inhibition of movements are impaired which may manifest itself in e.g. difficulty to start and stop walking. At single-joint level, impaired movement initiation is further accompanied by insufficient inhibition of antagonist muscle activity. As the motor symptoms in PD primarily result from cerebral dysfunction, quantitative investigation of gradually adjusted muscle activity during execution of purposeful movement is a first step to gain more insight in the link between impaired modulation of initiation and inhibition at the levels of (i) cerebrally coded task performance and (ii) final execution by the musculoskeletal system. To that end, the present study investigated changes in gradual adjustment of muscle synergists using a manipulandum that enabled standardized smooth movement by continuous wrist circumduction. Differences between PD patients (N = 15, off-medication) and healthy subjects (N = 16) concerning the relation between muscle activity and movement performance in these groups were assessed using kinematic and electromyographic (EMG) recordings. The variability in the extent to which a particular muscle was active during wrist circumduction – defined as muscle activity differentiation - was quantified by EMG. We demonstrated that more differentiated muscle activity indeed correlated positively with improved movement performance, i.e. higher movement speed and increased smoothness of movement. Additionally, patients employed a less differentiated muscle activity pattern than healthy subjects. These specific changes during wrist circumduction imply that patients have a decreased ability to gradually adjust muscles causing a decline in movement performance. We propose that less differentiated muscle use in PD patients reflects impaired control of modulated initiation and inhibition due to decreased ability to selectively and jointly activate muscles

Integrins as therapeutic targets: lessons and opportunities.

The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function. The identification of key roles for integrins in a diverse range of diseases, including cancer, infection, thrombosis and autoimmune disorders, has revealed their substantial potential as therapeutic targets. However, so far, pharmacological inhibitors for only three integrins have received marketing approval. This article discusses the structure and function of integrins, their roles in disease and the chequered history of the approved integrin antagonists. Recent advances in the understanding of integrin function, ligand interaction and signalling pathways suggest novel strategies for inhibiting integrin function that could help harness their full potential as therapeutic targets

A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity

Corticostriatal synapse plasticity of medium spiny neurons is regulated by glutamate input from the cortex and dopamine input from the substantia nigra. While cortical stimulation alone results in long-term depression (LTD), the combination with dopamine switches LTD to long-term potentiation (LTP), which is known as dopamine-dependent plasticity. LTP is also induced by cortical stimulation in magnesium-free solution, which leads to massive calcium influx through NMDA-type receptors and is regarded as calcium-dependent plasticity. Signaling cascades in the corticostriatal spines are currently under investigation. However, because of the existence of multiple excitatory and inhibitory pathways with loops, the mechanisms regulating the two types of plasticity remain poorly understood. A signaling pathway model of spines that express D1-type dopamine receptors was constructed to analyze the dynamic mechanisms of dopamine- and calcium-dependent plasticity. The model incorporated all major signaling molecules, including dopamine- and cyclic AMP-regulated phosphoprotein with a molecular weight of 32 kDa (DARPP32), as well as AMPA receptor trafficking in the post-synaptic membrane. Simulations with dopamine and calcium inputs reproduced dopamine- and calcium-dependent plasticity. Further in silico experiments revealed that the positive feedback loop consisted of protein kinase A (PKA), protein phosphatase 2A (PP2A), and the phosphorylation site at threonine 75 of DARPP-32 (Thr75) served as the major switch for inducing LTD and LTP. Calcium input modulated this loop through the PP2B (phosphatase 2B)-CK1 (casein kinase 1)-Cdk5 (cyclin-dependent kinase 5)-Thr75 pathway and PP2A, whereas calcium and dopamine input activated the loop via PKA activation by cyclic AMP (cAMP). The positive feedback loop displayed robust bi-stable responses following changes in the reaction parameters. Increased basal dopamine levels disrupted this dopamine-dependent plasticity. The present model elucidated the mechanisms involved in bidirectional regulation of corticostriatal synapses and will allow for further exploration into causes and therapies for dysfunctions such as drug addiction

Toward a Comprehensive Approach to the Collection and Analysis of Pica Substances, with Emphasis on Geophagic Materials

Pica, the craving and subsequent consumption of non-food substances such as earth, charcoal, and raw starch, has been an enigma for more than 2000 years. Currently, there are little available data for testing major hypotheses about pica because of methodological limitations and lack of attention to the problem.In this paper we critically review procedures and guidelines for interviews and sample collection that are appropriate for a wide variety of pica substances. In addition, we outline methodologies for the physical, mineralogical, and chemical characterization of these substances, with particular focus on geophagic soils and clays. Many of these methods are standard procedures in anthropological, soil, or nutritional sciences, but have rarely or never been applied to the study of pica.Physical properties of geophagic materials including color, particle size distribution, consistency and dispersion/flocculation (coagulation) should be assessed by appropriate methods. Quantitative mineralogical analyses by X-ray diffraction should be made on bulk material as well as on separated clay fractions, and the various clay minerals should be characterized by a variety of supplementary tests. Concentrations of minerals should be determined using X-ray fluorescence for non-food substances and inductively coupled plasma-atomic emission spectroscopy for food-like substances. pH, salt content, cation exchange capacity, organic carbon content and labile forms of iron oxide should also be determined. Finally, analyses relating to biological interactions are recommended, including determination of the bioavailability of nutrients and other bioactive components from pica substances, as well as their detoxification capacities and parasitological profiles.This is the first review of appropriate methodologies for the study of human pica. The comprehensive and multi-disciplinary approach to the collection and analysis of pica substances detailed here is a necessary preliminary step to understanding the nutritional enigma of non-food consumption