Computer program performs aerothermodynamic flight test data correlation

Computer program plots flight test data /stored on magnetic tape during the flight/ with comparative data from other tapes /design and post-flight predictions/. Information as to which measurements are on each tape, the order in which they appear, and the exact time span is supplied by the source of the data

The Effects of Triclosan on the Dvelopment of Rana Palustris

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

Turbidimetric Determination of Anionic Polyacrylamide in Low Carbon Soil Extracts

Concerns over runoff water quality from agricultural lands and construction sites have led to the development of improved erosion control practices, including application of polyacrylamide (PAM). We developed a quick and reliable method for quantifying PAM in soil extracts at low carbon content by using a turbidimetric reagent, Hyamine 1622. Three high-molecular weight anionic PAMs differing in charge density (7, 20, and 50 mol%) and five water matrices, deionized (DI) water and extracts from four different soils, were used to construct PAM calibration curves by reacting PAM solutions with hyamine and measuring turbidity development from the PAM–hyamine complex. The PAM calibration curve with DI water showed a strong linear relationship (r2 = 0.99), and the sensitivity (slope) of calibration curves increased with increasing PAM charge density with a detection limit of 0.4 to 0.9 mg L−1. Identical tests with soil extracts showed the sensitivity of the hyamine method was dependent on the properties of the soil extract, primarily organic carbon concentration. Although the method was effective in mineral soils, the highest charge density PAM yielded a more reliable linear relationship (r2 \u3e 0.97) and lowest detection limit (0.3 to 1.2 mg L−1), compared with those of the lower charge density PAMs (0.7 to 23 mg L−1). Our results suggest that the hyamine test could be an efficient method for quantifying PAM in environmental soil water samples as long as the organic carbon in the sample is low, such as in subsurface soil material often exposed at construction sites

Logarithmic asymptotics of the densities of SPDEs driven by spatially correlated noise

We consider the family of stochastic partial differential equations indexed by a parameter \eps\in(0,1], \begin{equation*} Lu^{\eps}(t,x) = \eps\sigma(u^\eps(t,x))\dot{F}(t,x)+b(u^\eps(t,x)), \end{equation*} (t,x)\in(0,T]\times\Rd with suitable initial conditions. In this equation, $L$ is a second-order partial differential operator with constant coefficients, $\sigma$ and $b$ are smooth functions and $\dot{F}$ is a Gaussian noise, white in time and with a stationary correlation in space. Let p^\eps_{t,x} denote the density of the law of u^\eps(t,x) at a fixed point (t,x)\in(0,T]\times\Rd. We study the existence of \lim_{\eps\downarrow 0} \eps^2\log p^\eps_{t,x}(y) for a fixed $y\in\R$. The results apply to a class of stochastic wave equations with $d\in\{1,2,3\}$ and to a class of stochastic heat equations with $d\ge1$.Comment: 39 pages. Will be published in the book " Stochastic Analysis and Applications 2014. A volume in honour of Terry Lyons". Springer Verla

Controls on the movement and composition of firn air at the West Antarctic Ice Sheet Divide

We sampled interstitial air from the perennial snowpack (firn) at a site near the West Antarctic Ice Sheet Divide (WAIS-D) and analyzed the air samples for a wide variety of gas species and their isotopes. We find limited convective influence (1.4–5.2 m, depending on detection method) in the shallow firn, gravitational enrichment of heavy species throughout the diffusive column in general agreement with theoretical expectations, a ~10 m thick lock-in zone beginning at ~67 m, and a total firn thickness consistent with predictions of Kaspers et al. (2004). Our modeling work shows that the air has an age spread (spectral width) of 4.8 yr for CO<sub>2</sub> at the firn-ice transition. We also find that advection of firn air due to the 22 cm yr<sup>−1</sup> ice-equivalent accumulation rate has a minor impact on firn air composition, causing changes that are comparable to other modeling uncertainties and intrinsic sample variability. Furthermore, estimates of Δage (the gas age/ice age difference) at WAIS-D appear to be largely unaffected by bubble closure above the lock-in zone. Within the lock-in zone, small gas species and their isotopes show evidence of size-dependent fractionation due to permeation through the ice lattice with a size threshold of 0.36 nm, as at other sites. We also see an unequivocal and unprecedented signal of oxygen isotope fractionation within the lock-in zone, which we interpret as the mass-dependent expression of a size-dependent fractionation process

Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was adapted to evaluate methotrexate transport in 69 high-grade osteosarcoma tumor samples. All samples studied were shown to have relatively impaired methotrexate transport by PT430 assay. Ninety-nine percent of the samples had less than 20% PT430 displacement by methotrexate. Eighty-eight percent exhibited displacement by methotrexate at less than 50% of the displacement by trimetrexate. The high frequency of impaired transport suggests the presence of decreased functionality of the reduced folate carrier protein. The overwhelming presence of impaired transport may explain why methotrexate needs to be given in high doses to be effective in osteosarcoma therapy and suggests that reduced folate carrier-independent antifolates should be explored

In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions

Non-O157 Shiga Toxin–Producing \u3ci\u3eEscherichia coli\u3c/i\u3e Infections in the United States, 1983–2002

Background. Shiga toxin–producing Escherichia coli (STEC) O157:H7 is a well-recognized cause of bloody diarrhea and hemolytic-uremic syndrome (HUS). Non-O157 STEC contribute to this burden of illness but have been underrecognized as a result of diagnostic limitations and inadequate surveillance. Methods. Between 1983 and 2002, 43 state public health laboratories submitted 940 human non-O157 STEC isolates from persons with sporadic illnesses to the Centers for Diseases Control and Prevention reference laboratory for confirmation and serotyping. Results. The most common serogroups were O26 (22%), O111 (16%), O103 (12%), O121 (8%), O45 (7%), and O145 (5%). Non-O157 STEC infections were most frequent during the summer and among young persons (median age, 12 years; interquartile range, 3–37 years). Virulence gene profiles were as follows: 61% stx1 but not stx2; 22% stx2 but not stx1; 17% both stx1 and stx2; 84% intimin (eae); and 86% enterohemolysin (E-hly). stx2 was strongly associated with an increased risk of HUS, and eae was strongly associated with an increased risk of bloody diarrhea. STEC O111 accounted for most cases of HUS and was also the cause of 3 of 7 non-O157 STEC outbreaks reported in the United States. Conclusions. Non-O157 STEC can cause severe illness that is comparable to the illness caused by STEC O157. Strains that produce Shiga toxin 2 are much more likely to cause HUS than are those that produce Shiga toxin 1 alone. Improving surveillance will more fully elucidate the incidence and pathological spectrum of these emerging agents. These efforts require increased clinical suspicion, improved clinical laboratory isolation, and continued serotyping of isolates in public health laboratories

Naive Yearling Steers Consume Little Sericea Lespedeza in the Kansas Flint Hills

Objective: The objective of this study was to characterize diets selected by steers grazing sericea lespedeza (Lespedeza cuneata)-infested native tallgrass pastures. Study Description: The experiment was conducted on eight native tallgrass pastures located in Woodson County, KS, at the Kansas State University Bessner Range Research Unit during the 2015 and 2016 growing season. Pastures were burned annually in April and stocked with yearling steers (n = 281/year; initial body weight = 582 ± 75 lb) at a relatively high stocking rate (2.7 acres/steer) from April 15 to July 15. Basal frequency of sericea lespedeza was 2.9 ± 2.43% during the period of our experiment. Four 328-ft transects were laid out in a north-south gradient in each pasture. Following a 2-week adaptation period, fecal samples were collected bi-weekly from fresh fecal pats along each transect from May 1 to July 15, annually. Fecal samples were prepared and viewed under a compound microscope to identify and count plant fragment species. These data were used to determine the frequency of which plant species appeared in steer diets. The Bottom Line: In this experiment, grasses comprised not less than 88.4% of steer diets, whereas forbs comprised not more than 11.6% of steer diets. Sericea lespedeza comprised only a minor proportion of grazing steer diets. This finding highlights the difficulty in achieving control over sericea lespedeza using grazing by yearling cattle alone

Grazing Diets of Mature Ewes in the Flint Hills Contain a Significant Proportion of Sericea Lespedeza

Objective: The objective of this study was to characterize diets selected by sheep grazing sericea lespedeza (Lespedeza cuneata) infested native tallgrass pastures and contrast these diets to those of cattle grazing the same range earlier in the grazing season. Multi-species grazing may provide an additional tool to aid landholders in the control of sericea lespedeza compared to cattle grazing only. Study Description: The study was conducted on 8 native tallgrass pastures grazed by more than 800 mature ewes. Pastures were infested with sericea lespedeza (basal frequency = 2.9 ± 2.43%) and stocked with yearling steers at a relatively high stocking rate (2.7 acres/steer) from April 15 to July 15 and subsequently grazed by sheep from July 30 to October 1. Fecal samples were collected from individual sheep on August 15 and on September 15 for 2 years. Samples were prepared and viewed under a compound microscope to identify and count plant fragments. These data were used to determine frequency at which each plant species appeared in diets selected by freely-grazing sheep. The Bottom Line: Sericea lespedeza comprised approximately 1.5% of sheep diets. Consumption at that level is likely sufficient to control seed production by that plant. Grazing of small ruminants in addition to cattle in a grazing system may provide landholders an additional tool for control of sericea lespedeza