Quality of Living Perceived of the Young People of the Vale do Sinos / RS/Brazil

The objective of this study was to identify the Quality of Life level of young people from Vale do Sinos / RS. The methodology was observational, descriptive and transversal. The sample had 391 young people. The data collection instruments were the WHOQOL-Bref and a socioeconomic questionnaire. Resulting in a total average score of 52.37 points, the highest for the Social Relations Domain and the lowest for the Environment. When compared to the variables "Sex", "Income" and "Age", the one with the highest statistically significant association among the domains was "Income", followed by "Sex" and "Age". It was concluded that the QoL of young people is smaller when compared with other studies, being relevant investments in public policies

Treatment Outcome of Acute Promyelocytic Leukemia with Modified Aida Protocol

We analyzed the outcome of a series of 19 newly diagnosed patients with acute promyelocytic leukemia treated with AIDA modified protocol, using mitoxantrone in place of idarubicin. Eleven patients achieved morphologic CR (58%). The remaining 8 patients had induction failure due to death during induction. Ten of eleven patients in CR achieved molecular remission after induction therapy and all the 8 patients had molecular remission after consolidation. Eight patients completed the three consolidation courses as scheduled and then proceeded to maintenance therapy. After a median follow up of 52 months, no molecular or hematological relapse has occurred. The 4-year disease-free survival is 82%. The study showed the antileukemic efficacy of mitoxantrone and that it could be used as a reasonable option in anthracycline-based strategies in APL

Clinical study of a multivitamin and polymineral complex associated with Panax ginseng extract (Natus Gerin®)

This study aimed to stablish the efficacy of a multivitamin and polyminerals supplemented with Panax ginseng extract (Natus Gerin®) on patients subjected to common physical or mental stress. Patients were randomly divided in two groups and underwent a thorough clinical examination. Group A received Natus Gerin® capsules and B placebo capsules. Two capsules were taken daily during meals during four weeks. Mood and physical activity were evaluated through a questionnaire assessing quality of life. From the 176 patients enrolled, 17 were excluded due to voluntary withdrawal, 81 completed the study in group A and 78 in group B. The treatment with Natus Gerin® increased the quality of life when compared to placebo. After 15 and 30 days, group A showed a significant increase in average scoring score from 1.78 to 3.78, and finally 5.32 points. The study has shown that the daily use of Natus Gerin® can be effective in improving quality of life in patients suffering from physical and mental stressColegio de Farmacéuticos de la Provincia de Buenos Aire

Magnetic field decay in black widow pulsars

We study in this work the evolution of the magnetic field in 'redback-black widow' pulsars. Evolutionary calculations of these 'spider' systems suggest that first the accretion operates in the redback stage, and later the companion star ablates matter due to winds from the recycled pulsar. It is generally believed that mass accretion by the pulsar results in a rapid decay of the magnetic field when compared to the rate of an isolated neutron star. We study the evolution of the magnetic field in black widow pulsars by solving numerically the induction equation using the modified Crank-Nicolson method with intermittent episodes of mass accretion on to the neutron star. Our results show that the magnetic field does not fall below a minimum value ('bottom field') in spite of the long evolution time of the black widow systems, extending the previous conclusions for much younger low-mass X-ray binary systems. We find that in this scenario, the magnetic field decay is dominated by the accretion rate, and that the existence of a bottom field is likely related to the fact that the surface temperature of the pulsar does not decay as predicted by the current cooling models. We also observe that the impurity of the pulsar crust is not a dominant factor in the decay of magnetic field for the long evolution time of black widow systems.Instituto de Astrofísica de La Plat

SAMARAS OF AUSTROPLENCKIA POPULNEA (CELASTRACEAE): NEW CONSTITUENTS AND EFFECT OF EXTRACTS AND FRIEDELIN ON GERMINATION OF BIDENS PILOSA (ASTERACEAE)

Objective: Evaluation of the impact of extracts and constituents from samaras of Austroplenckia populnea on percentage of seed germination (%SG), germination speed index (GSI), length of rootlets (LR), seedling length (SL), and on dry mass (DM) of Bidens pilosa L weed.Methods: The  powder  of  samaras  was  extracted  with  organic  solvents  providing  the  hexane  (SAPEH),  chloroform  (SAPEC),  ethyl  acetate  (SAPEAE) and ethanol  (SAPEE)  extracts. The terpene 1 was isolated from SAPEH by means of column and thin layer chromatography and identified through NMR spectroscopy. Each extract and 1 were subjected to growth inhibition assays evaluating the following parameters: %SG, GSI, LR, SL and DM, with five repetitions.Results: The compounds Friedelin (1), 7-hydroxy-clerodan-3-en-16,15:18,20-diolide (2), 3,5,7,4'-tetrahydroxy-6-methoxy-8-prenylflavanone (3), tetradecanamide (4), and 4-hydroxy-1,6,15-acetyloxy-8,9-benzoyloxy-agarofurane (5) were isolated from hexane extract of samaras of A. populnea and identified by spectroscopic data. The compounds 2, 3 and 5 were not previously described as being chemical constituents from Celastraceae family. In addition, the novel compounds 3 and 5 were described here for the first time. Substantial effect on the germination of B. pilosa L. (picão-preto) was observed after treatment of seeds with nonpolar extracts from Samaras of A. populnea. Friedelin inhibited the seed germination in the tested concentrations showing toxic properties against picão-preto.Conclusion: The germination inhibition of seeds was higher using nonpolar extracts than polar extract. Friedelin inhibited the seed germination in the tested concentrations showing toxic properties against B. pilosa.Â

Illicit drugs, metabolites and adulterants in wastewater : monitoring community drug abuse in the brazilian Federal District during the 2014 Soccer World Cup

A multiresidue method was developed to estimate community drug use during two weekends of the 2014 Soccer World Cup via wastewater analyses. Five of the 16 investigated substances were detected in all eight samples. Benzoilecgonine (BE), the major cocaine metabolite, was the most abundant substance (1.9 ± 0.3 to 4.2 ± 0.2 μg L-1) followed by anhydroecgonine (AE) (1.5 ± 0.2 to 2.6 ± 0.2 μg L-1), phenacetin (PHE) (0.62 ± 0.06 to 1.3 ± 0.1 μg L-1), levamisole (LEV) (0.5 ± 0.2 to 1.23 ± 0.09 μg L-1), and cocaine (COC) (0.46 ± 0.07 to 0.8 ± 0.1 μg L-1). COC and BE levels suggested a human consumption origin for the investigated drugs. AE/BE ratios revealed a significant use of smoked crack/free base cocaine. Relationships between the adulterants PHE and LEV evidenced a higher use of crack cocaine in the South-Wing WWTP region. An estimative for cocaine use revealed slightly higher drug consumption during the Soccer World Cup weekends in comparison with a typical weekend in 2012

Estratégias de tratamento para os erros inatos do metabolismo

Recent advances in the diagnosis and treatment of inborn errors of metabolism (IEM) have improved substantially the prognosis for many of these conditions. In the clinical practice it is important to recognize this pathology mainly in an acute situation, when the early intervention is essential. In this article, we presented some therapeutic strategies for IEM that should be used to improve their prognose.Recentes avanços no diagnóstico e tratamento dos erros inatos do metabolismo têm melhorado substancialmente o prognóstico de muitos pacientes com estas condições. Na pratica médica é importante o diagnóstico precoce destas patologias, especialmente em um paciente agudamente enfermo, para que um tratamento adequado e rápido seja instituído. Neste artigo, apresentamos várias estratégias terapêuticas para alguns erros inatos do metabolismo, que devem ser utilizadas no sentido de melhorar o seu prognóstico