GOVERNANÇA DE TI EM ESTATAIS: UMA AVALIAÇÃO SOBRE A CONTRIBUIÇÃO DOS INDICADORES PRESCRITIVOS DO TRIBUNAL DE CONTAS

Este trabalho teve como objeto de estudo o uso dos indicadores prescritivos, adotado pelo TCU para avaliar a Governança de TI. Por intermédio de questionário, aplicado aos gestores dessa área de uma grande estatal brasilleira, objetivou-se verificar a efetividade de tais indicadores a partir da percepção dos gestores de TI, na organização onde atuam. Devido à natureza investigativa, esse trabalho é técnico descritivo e exploratório, adotando a estratégia de estudo de caso, em uma empresa da administração pública, apoiada por análise de conteúdo categorial de Bardin. Fizeram parte dos achados fatores que não são capturados pelo questionário do TCU, como a forte influência de fatores políticos, da cultura e comportamento organizacional, de entidades externas - como a de órgãos reguladores – de fatores psicossociais do trabalho e da tecnologia, entre outros. Identificou-se forte tendência, no entendimento dos gestores, de que os indicadores prescricionais, usados pelo TCU, não geram a contribuição que se espera para governança de TI. Estes resultados, contribuem para o debate, principalmente no que tange a governança de TI e abrem espaços para novas pesquisas na área, que carece de outros estudos comparativos similares

Strategic Management in Public Administration: A Balanced Scorecard Applicability Framework in School Management

Purpose - This study aims at developing a framework of the Balanced Scorecard (BSC) in public educational organizations.Theoretical framework – There are 3-sections: Strategic planning in public sector, Balanced Scorecard and BSC in the public sector. Strategic management in public administration is an important issue, with the BSC as one of the most widely used tools. Although, the application of this technique in public schools is still unexplored and uncommon, it does possess the potential to improve their effectiveness.Methodology - A 3-stage qualitative approach: (i) 8 semi-structured interviews with the principals of participating schools; (ii) 4 stages of focus groups with 3 of the principals from different schools; and (iii) non-participant observation using a field diary. Also, the data were analyzed through content analysis and cross-referencing the different forms of data collected.Findings - The results do not indicate a vast knowledge concerning the BSC’s techniques and tools, or an alignment between management planning posture, principles nor objectives of BSC application. Also, school planning is realized through the expertise of the Principal, without instruments of strategic management. Finally, adapted BSC models and strategic maps were proposed in public schools to collaborate and facilitate the strategic management process.Research, Practical & Social implications - The paper contributes towards developing new research agendas for strategic management in Brazil, with the possibility of improving public results and to appoint new practices in public schools.Originality/value - We have collaborated with the creation of a tool to use in the strategic planning of primary schools and pushing BSC studies into public sectors

Ablaçao com mapeamento eletroanatômico de taquicardia ventricular recorrente refratária a terapia medicamentosa na cardiomiopatia dilatada isquêmica em portador de cardiodesfibrilador multissítio

As arritmias ventriculares em portadores de cardiomiopatia isquêmica estao diretamente relacionadas ao aumento da morbimortalidade, sendo sua recorrência associada a pior prognóstico. A despeito da otimizaçao do tratamento medicamentoso, muitos sao os pacientes refratários, e, nesse contexto, a ablaçao por radiofrequência torna-se uma importante alternativa terapêutica diante da refratariedade ao tratamento convencional. O mapeamento eletroanatômico permite visualizaçao das áreas de fibrose e dos istmos de conduçao, aumentando as taxas de sucesso desse procedimento

Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis

OBJECTIVE: To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis. METHOD: This cross-sectional study enrolled 127 dermatomyositis cases and 95 polymyositis cases. The disease-related autoantibody profiles were determined using a commercially available blood testing kit. RESULTS: The prevalence of myositis-specific autoantibodies in all 222 patients was 34.4%, whereas myositis-associated autoantibodies were found in 41.4% of the patients. The most frequently found autoantibody was anti-Ro-52 (36.9%), followed by anti-Jo-1 (18.9%), anti-Mi-2 (8.1%), anti-Ku (4.1%), anti-SRP (3.2%), anti-PL-7 (3.2%), anti-PL-12 (2.7%), anti-PM/Scl75 (2.7%), and anti-PM/Scl100 (2.7%). The distributions of these autoantibodies were comparable between polymyositis and dermatomyositis, except for a higher prevalence of anti-Jo-1 in polymyositis. Anti-Mi-2 was more prevalent in dermatomyositis. Notably, in the multivariate analysis, anti-Mi-2 and anti-Ro-52 were associated with photosensitivity and pulmonary disorders, respectively, in dermatomyositis. Anti-Jo-1 was significantly correlated with pulmonary disorders in polymyositis. Moreover, anti-Ro-52 was associated with anti-Jo-1 in both diseases. No significant correlation was observed between the remaining autoantibodies and the clinical and/or laboratory findings. CONCLUSIONS: Our data are consistent with those from other published studies involving other populations, although certain findings warrant consideration. Anti-Ro-52 and anti-Jo-1 were strongly associated with one another. Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis

Dimerização e trimerização de eteno catalisadas por Ni(acac)2NaX ou NaY/AlEt3

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Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity : a cross-sectional study

Background: The enzyme 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) converts inactive cortisone to active cortisol in a process mediated by the enzyme hexose-6-phosphate dehydrogenase (H6PD). The generation of cortisol from this reaction may increase intra-abdominal cortisol levels and contribute to the physiopathogenesis of obesity and metabolic syndrome (MetS). The relationship of HSD11B1 rs45487298 and H6PD rs6688832 polymorphisms with obesity and MetS was studied. We also studied how HSD11B1 abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) gene expression is related to body fat distribution. Methods: Rates of obesity and MetS features were cross-sectionally analyzed according to these polymorphisms in 1006 Brazilian white patients with type 2 diabetes (T2DM). Additionally, HSD11B1 expression was analyzed in VAT and SAT in a diferent cohort of 28 participants with and without obesity who underwent elective abdominal operations. Results: Although polymorphisms of the two genes were not individually associated with MetS features, a synergistic efect was observed between both. Carriers of at least three minor alleles exhibited lower BMI compared to those with two or fewer minor alleles adjusting for gender and age (27.4±4.9 vs. 29.3±5.3 kg/m2 ; P=0.005; mean±SD). Obesity frequency was also lower in the frst group (24.4% vs. 41.6%, OR=0.43, 95% CI 0.21–0.87; P=0.019). In the second cohort of 28 subjects, HSD11B1 gene expression in VAT was inversely correlated with BMI (r=− 0.435, P=0.034), waist circumference (r=− 0.584, P=0.003) and waist-to-height ratio (r=− 0.526, P=0.010). Conclusions: These polymorphisms might interact in the protection against obesity in T2DM individuals. Obese individuals may have decreased intra-abdominal VAT HSD11B1 gene expression resulting in decreasing intra-abdominal cortisol levels as a compensatory mechanism against central and general adiposity

Polymeric micelles containing resveratrol: development, characterization, cytotoxicity on tumor cells and antimicrobial activity

Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder cancer cell line and antimicrobial effect was evaluated on E. coli, S. aureus and C. albicans. One of the formulations (10% w/w of F127 and 5000 µM of resveratrol) was a monodispersed solution with high encapsulation rate, thus it was chosen for the cytotoxicity and antimicrobial assays. MS10+RES-3 was able to preserve the antimicrobial and cytotoxic activity of resveratrol. This is the first study that evaluated antimicrobial potential and cytotoxicity of micelles containing resveratrol on bladder cancer cells and the results showed that micellar nanostructures could ensure the maintenance of the biological activity of resveratrol

Yield and quality of melon under silicon doses and irrigation management in a greenhouse

The netted melon requires special growing conditions, including a protected environment, an adequate staking system and proper water and nutrient management. This study aimed to assess the effect of irrigation levels and silicon doses on the yield and quality of Sunrise hybrid melons, in a greenhouse. A randomized block design was used, with a 5 x 3 factorial scheme and four replications. The first factor consisted of five silicon doses (0 kg ha-1, 50 kg ha-1, 100 kg ha-1, 150 kg ha-1 and 200 kg ha-1) and the second of three irrigation levels (40 %, 70 % and 100 % of the ETc). The results demonstrated that the applied irrigation levels and silicon doses have no influence on the yield traits of melon plants. The irrigation level corresponding to 100 % of the ETc promotes higher values for soluble solids (9.86 ºBrix) and maturation index (114.9) on fruits. The increase of silicon doses up to 200 kg ha-1 also increases the maturation index in the treatment with the greatest irrigation level and reduces this index at the shallowest level applied